#75

I didn’t see the OP medical history, drug selection even within the class can be very individualized.
Rosuvastatin has supposedly lowest risk for myositis and has a potent effect which allows for minimal dosing.

#76

With K2 the different MK isoprene residues matter. MK4, Mk7 an Mk9 are available as supplements.

Mk7 has a different effect on me to Mk4. Mk7 disrupts sleep which endorses it having effects on ATP generation. (more ATP → less sleep)

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#77

I would prefer to know a far more important “stack” – i.e., what your daily diet consists of. Supplements are just that, supplements.

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#78

Interesting. I have been battling some sleep issues for a couple weeks. After a quick review, I think my combination of therapies such as Mk7, red light, etc, may be pushing ATP too high. I will explore this some more, thanks.

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#79

Mk7 is the most likely culprit. Is shows it works, however. Red light probably does not affect the brain as much.

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#80

Why would that matter? Why doesn’t the effect/side effects depend on for example total HMGCR inhibition, rather than amount of compound to HMGR inhibition ratio, if my question makes sense?

#81

I tend to agree. My limited research thus far, has shown that Mk7 has a half-life of approximately 72 hours, so daily dosing could cause higher levels to build up and also cause constant ATP activation. RLT effects on ATP are relatively short-lived (4–6 hours).

Two other supplements that have a longer duration of ATP activation and may disrupt sleep:
PQQ has a half-life of 2–5 hours, but its effects on mitochondrial biogenesis and ATP production can persist for days due to the creation of new mitochondria.

CoQ10’s half-life is approximately 21–37 hours, so its ATP-enhancing effects can last 1–2 days with peak effects occurring a few hours after ingestion.

1 Like
#82

John, Why would mk7 cause mitochondria to make more energy than the body needs? If it is making the ETC more efficient (lose fewer electrons to ROS), why wouldn’t a homeostasis effect kick in the lower atp production?

If it is more like a toxin that the body must deal with as soon as possible, then I’d understand this sort of effect.

Is the known Vitamin K2 as MK-7 beneficial effect arterial calcification coming from a mitochondrial effect? Is this known?

#83

Here’s mine. I included my lifestyle interventions as my supplements are a small part of my health and longevity effort. I skipped my meds: rapa, bempadoicacid w/eze, sglt2, tadalafil

Fire away

Chemical supplements

  1. Aspirin 325mg plus 1g EPA/DHA in fish oil EOD (non lift days)
  2. K1/2 (super K: 2600 mcg EOD
  3. Melatonin 20mg at night
  4. Methylene Blue 10-15mg at night 3-5 days/ week
  5. Creatine 7g daily
  6. Carnitine (330mg x2 daily)
  7. Chromium picolinate 1000 mcg/day (blood sugar)
  8. Niacin 500mg plus activated charcoal (2x/wk before workout/sauna for detox)
  9. Lithium orotate 5mg (2-3x/week)
  10. Vitamin D 10k IU 3 days/week
  11. Taurine 3g before weight lifting

Food supplements

  1. Collagen 20g EOD (non lift days)
  2. Nitrate / Nitrite ~1g/day

Lifestyle actions

Sleep

  • Asleep by 930pm
  • No TV at night / computer use with dimmed screen
  • Low light / red lights after sunset
  • Cell phone off
  • White noise
  • Pulsetto just before sleep

Diet:

  • No: alcohol (mostly), processed food (mostly), added sugar or fat, snacking
  • 30 plants every week / 50-80g fiber per day
  • Fish / eggs are only animal proteins (plus collagen). Total protein: 75g/day non lift days, 150g/day lift days
  • No food after 7pm
  • 24 fast 1x/week
  • 5-day FMD 1x/3 months

Exercise:

  • Lift to failure full body 3x/week
  • 3 - 4 HIIT spin classes per week

Other

  • Sunshine everyday (mostly)
  • Red/NIR light every morning (full spectrum bulb on desk soon)
  • Sauna (185F) 30 minutes 3-5x/week plus cold shower daily
  • Nasal breathing almost all the time (and daily sinus rinse)
  • Daily mobility routine & bar hang
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#84

Its more energy than expected. The body can adjust. Personally i think the benefits from k2/mk7 are mainly from increased ATP, but gla complex issues also matter

#85

Are all statin side effects mediated via HMGCR ? Generally drug dose correlates with side effects, so efficacy achieved with least amount is more desirable.

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#86

Lots of good things here, some of which I don’t know . My only comment would be re creatine mono. As we age into our 50s I would bump it up to 6 grams the 7 eventually.
John Maccorkindale

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#87

Potentially a separate thread idea?

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#88

Interesting. Can you tell us how you ended up with this dose and timing of Methylene Blue.

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#89

MB dosing was from personal experimentation. At first I used it for brain fog. I used it whenever I needed it (usually in the afternoon). After a while of focusing on mitochondrial health, I stopped having brain fog issues so I didn’t need MB very often. Later I heard Doris Loh say that sleep problems can be from mitochondrial disfunction. She was speaking about the use of high dose melatonin but I thought I’d try MB before bed. It worked like a charm. I also like how MB accumulates in the bladder killing any bacteria that may have gotten there.

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#90

I like the idea of focusing on diet. For example, there are eight kinds of plant foods: fruit, vegetables, nuts and seeds, beans and legumes, whole grains, herbs and spices, seaweed, and mushrooms. We should all strive to eat from all eight categories.

#91

Thank you for sharing. Further ahead, I will try MB before sleep.

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#92

Awesome! Start low, go slow.

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#93

Yes, I will start very low. I have not managed to get MB to work very well on me, when I take it in the morning. it will be interesting to see how it affects my sleep when I take it before I go to bed. But right now I have a routine that works well for my sleep, so I will wait some time before I try MB.

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#94

Ha, blast of nostalgia, old school supplement list, what with stuff like chromium picolinate… I remember that one back in the day when it first broke out into the hype cycle :grin:, then it eventually died down, but the stalwarts kept faith, and you can encounter them, still popping the old picolinate, always nice to see!

Nice list, JL, not much one can quibble with, except maybe aspirin and MB for the purists.

Which reminds me, when you talk to some older health enthusiasts, many of them mirror other aspects of older folk. You know, how at a certain point they stop buying new clothes, all their electronics are like 30 years out of date, old music and so on. Well, it’s the same with their health practices and supplements can also get frozen in time, so you’ll see some weird stuff like “geritol” or some brand from the 50’s or 60’s or whatnot, like you wonder that anyone still makes those brands and supplements.

Of course, folks on this list tend to be sharp and look for the latest most validated stuff regardless of age, like desertshores, so you’re not gonna find them on this site, but it’s funny to consider how some people just seem to run out of gas and stop researching, and their health practices reflect that. There are many ways to avoid stagnation, and one way is to keep interacting with prominent people in the field, like JL does through his podcast (and which is likely why he’ll never get actually old, lol), or just participating actively on sites like this. The key is to avoid isolation, whether physical or intellectual.

I like JL’s approach of not too many supps - I wish I was as disciplined.

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