#62

@GregordianKnot does your multivitamin have vitamin C, K, and D in it? You could probably decrease the C, D, and Omega 3 doses.

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#68

Fascinating, thank you for sharing! I take Dutasteride so I’m assuming effects would be similar.

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#69

What is the danger if D is in range? Is there a danger from too much K2?

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#70

A post was merged into an existing topic: Hypertension drugs damage kidneys

#71

Vitamin A D E K are fat soluble so they can accumulate unlike vitamin C.
Hypervitaminosis is well known with A and D.

There is just not enough evidence of a benefit to push the vitamin dose up to the threshold for “optimal range” set between VITAMIN D,25-OH,TOTAL 30-100 ng/mL (set by Sonora Quest labs) but getting it over the insufficiency category so say over 20-30 ng/mL sounds reasonable.

When the correlation studies with low vitamin D and multiple allergy conditions started coming out 15-20 years ago, we were very excited initially. Unfortunately most intervention failed to produce any improvements in those conditions which mirrored lack of any improvement in my patients as well that were treated with VD replacement. These days I will still check the VD levels as part of urticaria, immunodeficiency, severe asthma or rhinosinusitis work up but I typically don’t bother treating unless the levels are under 30 ng/mL, otherwise their PCP can decide how to proceed.

Personally with family history of kidney stones I keep my levels of under 50 ng/mL. Apparently over 50 there is some risk developing of hypercalciuria, (over 150 there is a good chance for full on toxicity). The benefit of Vit D beyond clearing the deficiency or insufficiency range of 30 ng/mL is do dubious it just doesn’t meet benefit over risk ratio.

K2 replacement is pretty new, I think we are yet to see what would iatrogenic overdose would look like. I have zero experience with K2 personally, I know the purported benefits and it’s in Sports Research Vitamin D3 K2 with 5000iu of Plant-Based D3 & 100mcg of Vitamin K2 as MK-7 which I take 1-2 per week.

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#72

FYI: Atorvastatin is superior in terms of side effects for new onset diabetes and cataract surgery:

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#73

My D is around 50 and so I know the correct dosage to keep it these but I’ve been mega dosing K2 as part of a protocol to try to help mitigate my CVD because I didn’t realize there was a danger from dosing too high.

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#74

I didn’t say there was all I said there is for other fat soluble vitamins and K2 supplementation is relatively new.
Your risk vs benefit ration is clearly different from mine, so it MAY make sense for you.
These are tough calls we have to make

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#75

I didn’t see the OP medical history, drug selection even within the class can be very individualized.
Rosuvastatin has supposedly lowest risk for myositis and has a potent effect which allows for minimal dosing.

#76

With K2 the different MK isoprene residues matter. MK4, Mk7 an Mk9 are available as supplements.

Mk7 has a different effect on me to Mk4. Mk7 disrupts sleep which endorses it having effects on ATP generation. (more ATP → less sleep)

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#77

I would prefer to know a far more important “stack” – i.e., what your daily diet consists of. Supplements are just that, supplements.

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#78

Interesting. I have been battling some sleep issues for a couple weeks. After a quick review, I think my combination of therapies such as Mk7, red light, etc, may be pushing ATP too high. I will explore this some more, thanks.

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#79

Mk7 is the most likely culprit. Is shows it works, however. Red light probably does not affect the brain as much.

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#80

Why would that matter? Why doesn’t the effect/side effects depend on for example total HMGCR inhibition, rather than amount of compound to HMGR inhibition ratio, if my question makes sense?

#81

I tend to agree. My limited research thus far, has shown that Mk7 has a half-life of approximately 72 hours, so daily dosing could cause higher levels to build up and also cause constant ATP activation. RLT effects on ATP are relatively short-lived (4–6 hours).

Two other supplements that have a longer duration of ATP activation and may disrupt sleep:
PQQ has a half-life of 2–5 hours, but its effects on mitochondrial biogenesis and ATP production can persist for days due to the creation of new mitochondria.

CoQ10’s half-life is approximately 21–37 hours, so its ATP-enhancing effects can last 1–2 days with peak effects occurring a few hours after ingestion.

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#82

John, Why would mk7 cause mitochondria to make more energy than the body needs? If it is making the ETC more efficient (lose fewer electrons to ROS), why wouldn’t a homeostasis effect kick in the lower atp production?

If it is more like a toxin that the body must deal with as soon as possible, then I’d understand this sort of effect.

Is the known Vitamin K2 as MK-7 beneficial effect arterial calcification coming from a mitochondrial effect? Is this known?

#83

Here’s mine. I included my lifestyle interventions as my supplements are a small part of my health and longevity effort. I skipped my meds: rapa, bempadoicacid w/eze, sglt2, tadalafil

Fire away

Chemical supplements

  1. Aspirin 325mg plus 1g EPA/DHA in fish oil EOD (non lift days)
  2. K1/2 (super K: 2600 mcg EOD
  3. Melatonin 20mg at night
  4. Methylene Blue 10-15mg at night 3-5 days/ week
  5. Creatine 7g daily
  6. Carnitine (330mg x2 daily)
  7. Chromium picolinate 1000 mcg/day (blood sugar)
  8. Niacin 500mg plus activated charcoal (2x/wk before workout/sauna for detox)
  9. Lithium orotate 5mg (2-3x/week)
  10. Vitamin D 10k IU 3 days/week
  11. Taurine 3g before weight lifting

Food supplements

  1. Collagen 20g EOD (non lift days)
  2. Nitrate / Nitrite ~1g/day

Lifestyle actions

Sleep

  • Asleep by 930pm
  • No TV at night / computer use with dimmed screen
  • Low light / red lights after sunset
  • Cell phone off
  • White noise
  • Pulsetto just before sleep

Diet:

  • No: alcohol (mostly), processed food (mostly), added sugar or fat, snacking
  • 30 plants every week / 50-80g fiber per day
  • Fish / eggs are only animal proteins (plus collagen). Total protein: 75g/day non lift days, 150g/day lift days
  • No food after 7pm
  • 24 fast 1x/week
  • 5-day FMD 1x/3 months

Exercise:

  • Lift to failure full body 3x/week
  • 3 - 4 HIIT spin classes per week

Other

  • Sunshine everyday (mostly)
  • Red/NIR light every morning (full spectrum bulb on desk soon)
  • Sauna (185F) 30 minutes 3-5x/week plus cold shower daily
  • Nasal breathing almost all the time (and daily sinus rinse)
  • Daily mobility routine & bar hang
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#84

Its more energy than expected. The body can adjust. Personally i think the benefits from k2/mk7 are mainly from increased ATP, but gla complex issues also matter

#85

Are all statin side effects mediated via HMGCR ? Generally drug dose correlates with side effects, so efficacy achieved with least amount is more desirable.

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#86

Lots of good things here, some of which I don’t know . My only comment would be re creatine mono. As we age into our 50s I would bump it up to 6 grams the 7 eventually.
John Maccorkindale

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