#451

Don’t trust Dr. GPT. It wraps up by saying to take it daily.

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#452

What does “level 1” involve? Seems to me he is swayed by the popular literature. I say throw all the hoi polloi books away. I get a bad taste in my mouth when people take them as gospel.

I like that he provides a brief rationale for all his supplements. Can’t say I believe that they are all working magnificently in concert to extend his healthspan. It seems to me that something is wrong with a protocol that requires that much detail and that many regulations.

Regarding mental health, I don’t believe in CBT (I’m really stubborn) but JS Bach works for me.

Not sure the sterilizer fans are really good for people. But I live with 3 large dogs.

His links are dead now. He must be planning on selling stuff soon.

Thanks for sharing!

1 Like
#453

He’s moved some of the information over to this new site: https://rejuvenationolympics.com

Not sure what he’s doing with his personal site… probably a new company website coming…

A recent interview: Biohacking Bodyclocks: Meet Oliver Zolman MD, Founder of Living Younger Clinics - nia-faraway

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#454

Great thread here. Just discovered it, and am currently taking Rapamycin at 5mg, 1x/wk.

What is JBNSF?

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#455

@Ben_Greenfield Hello Ben. Are you that Ben Greenfield? I love your show. Welcome to the party! I’m 6mg/10 days.

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#456

See here:

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Abstract

Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM) onto the substrate, nicotinamide (NA) to form 1-methyl-nicotinamide (MNA). Higher NNMT expression and MNA concentrations have been associated with obesity and type-2 diabetes. Here we report a small molecule analog of NA, JBSNF-000088, that inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease. In mice with high fat diet (HFD)-induced obesity, JBSNF-000088 treatment caused a reduction in body weight, improved insulin sensitivity and normalized glucose tolerance to the level of lean control mice.

Full Paper:

https://www.nature.com/articles/s41598-018-22081-7

Sources:

https://www.selleckchem.com/products/jbsnf-000088.html

https://www.sigmaaldrich.com/US/en/product/sigma/sml3431

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NMN/NR worth taking for longevity?
#457

Yeah, I guess I’m that Ben Greenfield. LOL. At first glance a lot of people way smarter and more experienced than me on this thread. The way I found this thread is that I do some coaching with a few folks and one of my clients said he takes JBNSF so I looked it up and this is one of the few places it appears, hence, here I am (*btw, that is interesting it’s role as an NNMT inhibitor as to this point I was only aware of caloric restriction and possibly glutamine for that).

Maybe if I get the time at some point, I’ll sit down and type out my own protocol here, but this is what it looked like a few months ago, before I introduced rapamycin: Ben Greenfield's Latest "Age Reversal" Lab Testing Results

Only other significant modifications since making that post is:

-one vial of xogenix exosomes 1x/wk self-administered as IV
-iodine dosing 1000mcg 2x/wk
-1mg amanita muscara mushroom 2x/wk pre-bed for dreaming/emotional processing
-using neuronic red light helmet in biphasic dosing morning/evening
-doing some glycanage testing and digging into research behind glycation as an aging marker

Anyways, I’ll dig through this thread a bit as it looks like some great info here.

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#458

@Ben_Greenfield Fantastic! RapAdmin runs this place very well, and with a light touch. The participants here are smart, and generally make an effort to get along. I continue to learn a lot here, and I contribute what I can. Happy to learn from you as well.

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#459

AFAIK this it the best informed biohacking forum. Good quality science and not that much woo woo. There is a bit of woo woo, but I think the moderator is best to allow a bit of lunacy. Anyone with competent cognition can discount it.

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#460

Wow, what an interesting website. It looks like there is a lot of information to parse through there. I think it would be interesting to see and track more pedestrian lab results in addition to the biological age stats.

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#461

Oh, and be sure to share any findings on Glycation: markers and solutions. I’m investigating this area myself.

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#462

Interesting that someone is taking this already. Do you have a feeling for his results using JBNSF?

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#463

Good enough for Richard Branson, good enough for me: Coffee, Kiwi and Green Tea:

Screenshot 2023-08-06 at 3.20.05 PM
Screenshot 2023-08-06 at 3.20.05 PM1728×524 63.7 KB

https://www.inc.com/jessica-stillman/richard-branson-diet-health-tips.html

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#464

Welcome Ben, what made you decide to start rapamycin? You have tweeted about “thinking about it” so what was the deciding factor for you? I know you are a science guy, enjoyed watching your youtube for many years. How is your mum doing with her ALS?

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#465

Ross Pelton’s book initially let me down the rabbit hole, and I am preparing and researching for a podcast interview with him, and my modus operandi, as usually to guinea pig stuff on myself prior to a podcast anyways. :wink:

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#466

Welcome Ben! I have enjoyed your articles and view points over the years. I loved your article on Gainswave several years ago and have given that to several patients through the years. You’re off the cuff comments on ‘Jessica Rabbit’ and Grandma restaurant scene post treatment were epic. I went through training for Gainswaive in Miami years ago and they gave us your article.

Interesting longevity choices that you posted. Exosomes I don’t believe have been covered here much, but a good topic to explore since it seems to be the current fad.

Look forward to your input!

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#467

great new paper on exosomes: Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence | Scientific Reports

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#468

Nice study! Would love to hear your personal experience with exosomes value to risk for you.

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#469

Josh Mitteldorf reviews the exosomes paper @ https://joshmitteldorf.scienceblog.com/

“For all those involved in parabiosis and plasma exchange research, I suggest that it should be an immediate priority to replicate the Smidt findings that all of the rejuvenating power of young blood is contained in EVs. The Conboys might be interested in asking whether the pro-aging effect of plasma infusions from old to young animals is also an effect of EVs.”

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#470

Hi folk’s!

The supplements I’m taking for the time being are:

Fish oil Möllers liquid, ≈10 ml
Arginine-AKG ≈ 2 gr x3
Collagen ≈15 gr
MSM ≈ 400 mg
Glucosamine 1 gr
Creatine 3-5 grams
1/2 strong vitamine b-complex
K2 MK-7 75 mcg
3-6 mg boron
Vitamine D 4000 IU

Pharmaceuticals:
2 mg tadalafil
125 mcg levaxine (T4)
10-20 mcg Liotyronine (T3)
6,25 mg, enclomiphene eod

Have also eaten enormous amounts of homemade probiotic yoghurt. Made from L. Reuteri and “Lacto Vitalis Pro” which is a multi strain probiotic. (Out of it since a few weeks, but will restart that project)

Used to eat loads of raw cacao powder with my oat-smoothies, like 5 to 8 Tbs a day, but out of it right now, and learned here that it’s may be a source of cadmium, so a little break might be good…

Used to ad 5-7 grams of Glycine to my smoothies, but have found out that it makes me a bit to lazy…

Recently started taking Taurin, but find that it also makes me a bit tired and lazy, at least in higher dosages. Now take it with higher amounts of caffeine before the extra heavy workouts, or together with glycine and the minerals below as a sleep aid. To much and it might become harder to start the next day without extra coffee, which I already drink to much of…

Magnesiumglycinat 500-1000 mg, at night
Zinc 6-20 mg elemental, at night.
1 mg of lithium
(Gkycine) when needing a sleep boost
(Taurine) when needing a sleep boost

Have also recently ordered rapamycin from India. Think I will opt for 4-6 mg every 7-10 days, but maybe start as low as 2mg to see that I tolerate the drug.

My biggest concern about my “stack” is whether there are to many blood-thinning ingredients… and if some of the pills could interact in harmful ways with the rapamycin… thought on that, or something else? Feel free to hiss or diss! :blush:

I’m eating a flexitarian diet with loads of salad, legymens,broccoli, red beets, carrots and other veggies.

I Exercise quite a lot mist of the time. Mainly weight lifting, BJJ and running, and during intense periods suplement with oat/skimmed milk-gainers, and homemade peanut butter- oat- honey- and whey powder-bars to meet my macro needs.

I try to eat mainly low glycemic index food.
I also drink ay to much coffee, but trying to gradually exchange a few of the cups for green tea.

Another ambition is to implement more training in the second heart rate zone, since it’s supposed to be the magic bullet when it comes to recovery and building a base for better coping with more intense training sessions.

All the best,
Leonard

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