#475

Crestor might be better FYI since it is hydrophilic rather than lipophilic, meaning it can’t cross the BBB easily. But good decision, as long as you’re not getting side effects or speculatively low blood desmosterol as the latter is associated with alzheimer’s (especially important if you have ApoE4 allele(s)). Also apoB is preferable to LDL.

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#476

They do not work the same way. Lithium orortate is elemental lithium, which studies show trace doses of up to 1mg improve many pyschological symptoms. If that is not enough low dose lithium orotate which is considered 5mg can be taken. I wouldn’t be cutting lithium carbonate tablets as lithium orotate is pretty cheap and you want it in the elemental trace form. Besides there are side effects and many interactions at higher doses unless you need it prescribed for real issues.

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#477

I just started taking enclomiphene last week. I’ll keep you posted once I get post-bloodwork on FH/LSH, which have been a bit suppressed of late. So far, I haven’t noticed much from it but just a few days in.

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#478

how do you dose the 3g Taurine? all at once?

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#479

could you share your current stack? that would be greatly appreciated!

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#480

I have a long-standing issue with eczema and later it becomes eczema and psoriasis depending on the day. When it got really bad, I had to be on prednisone. That is until Dupixent came along and it really helped but only about 70%.

I started Sirolimus 1 or 2mg for psoriasis, I did great within a month. When I stopped, my psoriasis come back. So I am sticking to 1 or 2mg of Sirolimus 5 days a week along with 500 mg metformin daily. I am also on Crestor 10mg because of Peter Attia and my lipid is slightly high for me.
I am not doing the weekly dose because of my chronic condition, I am assuming daily would be working better for me for now. But I really wanted to try the weekly regimen.

I am a big fan of fish oil, Magnesium L-Threonate, NR, alpha lipoic acid, milk thistle, and Gingko.

I am thinking of adding LDN and Colchichine to my stack: one is for my psoriasis and one is for my heart health.

One that I am not sure about is acarbose and how to convince my doctor about it as I am not overweight or DM2.

I am pretty sure I have an overactive immune system. But I don’t know how to diagnose it or test for it. The fact Sirolimus worked for me is kind of a litmus test of that I suppose. Since on Sirolimus, I feel great.

Also, I take my sirolimus and metformin at night to further the autophagy effect as I generally don’t eat until next noon.

Any comments are appreciated.

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Rapamycin and psoriasis
#481

What dosage are you taking? Did you go for the ed or eod administration routine?

#482

To boost your testosterone?
Unfortunately enclomiphene is not available in Europe as prescription medicine. I was looking into it a while ago. In Europe you can get clomiphene prescription or you can source enclomiphene as a bodybuilding PST trough this shady underground SRAMs market. Is enclomiphene medicine in USA? Can you get a prescription or is it considered bodybuilding enhancement protocol/PCT?

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#483

I got mine from Maximus, who I think was mentioned elsewhere on this forum.

#484

I don’t actually have experience with psoriasis, but what I’ve read is that UVB like the Sperti can have dramatic influence. It doesn’t just make vitamin D.

I’m wondering how much time you spend in the sun unprotected, what time of day. And what is your vitamin D. Just curious, only if you want to share.

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#485

I know some gym rats that are using Anastrozole, an estrogen suppressor, along with TRT or by itself. Since it is not commonly prescribed, they get it from India. It is quite inexpensive from India. It is known to enhance TRT.

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#486

I spend a lot time in sun and I don’t like sunscreen so that may be part of the reason. I have not had my vit D tested recently but was normal long time ago. I tried UVB and I did not like it.

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#487

Yup, I take the taurine all at once. I’ve noticed no effects from it at all.

On that note: I’ve noticed no effects at all (good or bad) from almost everything in my stack (including Rapamycin). If I stop taking all of it, I feel exactly the same.

The only thing I take that I definitely notice the effects from is the tadalafil.

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#488

I think younger people, and I consider 40 young, who are healthy won’t experience anything but negative or no effects from supplements. What is there to fix? But, supplements are somewhat like your car maintenance. You change the oil but feel no effect, but you know it’s going to extend the life of your car.

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#489

Good! Please do report back your results. I did some light digging that not only it was refused by EMA bit also FDA and further trials and development for enclomiphene citrate were ceased, so now it is in gray area of SARMs and similar substances.
Studies I checked are quite promising. I myself have quite low testosterone levels (don’t really feel much symptoms as my free T is ok) and in September I have scheduled an appointment with a specialist to discuss options. One option might be TRT, second could probably be clomiphene citrate, which I read has many side effects… maybe I can usr enclomiphene as an option too and discuss it with the doctor.

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#490

@desertshores The exceptions (for younger people) are the performance enhancers, such as creatine, beta alanine (very good for power athletes), whey protein, citrulline (maybe).

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#491
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#492

I have taken supplements for decades including the ones you have mentioned in the hope of extending healthspan. Since I am not an athlete maybe I missed feeling the benefits.
As I have gotten old, I now do sometimes really notice the effects of supplements that I am taking. The first supplement that really changed how I felt was Boswellia Serrata extract. It is an anti-inflammatory that has a special affinity for joints, especially the knee joint. I had problems with my knees for years as a result of jogging and playing tennis. After only a few days of taking Boswellia Serrata, my knee pains went away. Then after a few weeks of rapamycin, I became virtually pain-free over my entire body.
I do count my blessing of being pain-free at my age. It’s something I think about and notice every day.

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#493

"simple: do nothing. "
I agree. Lower testosterone also has the benefit of moving the axis of thinking more toward the actual brain.

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#494

+1 for mentioning boswellia. Six months of rapa did nothing for my hand osteoarthritis. Since starting bos six weeks ago, still have some pain (take just one a day), but the inclination to yelp when I hit my right thumb and forefinger the wrong way has stopped. Justified the cost of a rapa.news subscription right there!

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