Chat GPT is kind of suggesting a dose for me of daily rapamycin between 11 mg and 1554 mg/day for longevity
does rapamycin used for longevity have a mg/kg dosage target?
Yes, rapamycin, a drug that has been shown to extend lifespan in some animal models, does have a target dosage range in terms of milligrams per kilogram of body weight (mg/kg).
The optimal dosage of rapamycin for lifespan extension is still being studied, but in animal models, it typically ranges from 0.1 to 14 mg/kg, depending on the species, sex, age, and other factors. However, it’s important to note that the optimal dosage for humans is still unknown and is an active area of research.
Rapamycin is not currently approved by the US FDA for use in anti-aging or longevity applications, and there are potential risks and side effects associated with its use. It’s always important to consult with a medical professional before taking any medication or supplement, especially for off-label uses.
what is the mouse to human conversion equation for dosage?
Converting dosages from animal studies to equivalent dosages in humans can be challenging due to differences in metabolic rates, body size, and other factors between species. There is no one-size-fits-all conversion equation for mouse to human dosages.
One common approach is to use a scaling factor based on body surface area, which takes into account the differences in body size between species. This approach is known as the “body surface area normalization” method and uses the following equation:
Human dose = (animal dose x (animal weight in grams^0.67)) / (human weight in grams^0.67)
In this equation, the animal dose is typically expressed in milligrams per kilogram of body weight (mg/kg), and the human dose is also expressed in mg/kg. The body weight exponents of 0.67 are used to account for the non-linear relationship between body weight and surface area.
However, it’s important to note that this method is not always accurate and may need to be adjusted based on the specific drug or compound being tested, as well as other factors such as the age, sex, and health status of the animals and humans involved. It’s always best to consult with a medical professional when determining appropriate dosages for any medication or supplement.
what would the dosage be of rapamycin for a 111kg human if the 0.1 to 14 mg/kg equation is used?
Assuming we use the range of 0.1 to 14 mg/kg of rapamycin for a 111 kg human, the corresponding dosage range would be:
- Minimum dose: 0.1 mg/kg x 111 kg = 11.1 mg
- Maximum dose: 14 mg/kg x 111 kg = 1,554 mg
It’s important to note that the optimal dosage of rapamycin for humans is still being studied and is not yet established. Rapamycin is not currently approved by the US FDA for use in anti-aging or longevity applications, and there are potential risks and side effects associated with its use. It’s always important to consult with a medical professional before taking any medication or supplement, especially for off-label uses.
is this a daily dosage?
The dosage of rapamycin would typically be taken daily, assuming that the purpose of taking the drug is for longevity or other chronic conditions. However, it’s important to note that the optimal dosage and dosing frequency of rapamycin for humans is still being studied and is not yet established.
It’s also important to emphasize that rapamycin is not currently approved by the US FDA for use in anti-aging or longevity applications, and there are potential risks and side effects associated with its use. It’s always important to consult with a medical professional before taking any medication or supplement, especially for off-label uses.
