Looking into this a little more… It does seem that the cost has potential to come down a lot in terms of the plasmapheresis services pricing. Cost of the equipment seems to be in the $30K to $50K range, they currently pay donors (on avg.) about $100 per liter of blood, disposables used in the process are about $1,500 to $3,000 per patient.
Of course overhead is also substantial, as it takes 3 hours or so to do a TPE session, so you have a very limited number of clients that you could cycle through the office in a 8 hour day (2.6 clients per day per machine) - so its hard to make a low price up with higher volume. What is likely needed is a 5 or 10 person plasmapheresis machine, or a low cost home machine. Probably easiest to do a 5 to 10 person machine for the existing companies, as they don’t have the skillset or cost basis for a lower cost home device.
Perhaps this is a service that every gym and healthspa will have in the future. The issue / cost / expertise issue seems to be the venous insertions / draws; you don’t want someone who can’t get the large needles / cannulas into your veins quickly and easily. I had one newbie nurse try twice on one of my visits for TPE and failed both times, before getting a more experienced person. If the nurses make a lot of mistakes, I suspect your arm quickly starts looking like that of a drug addict.
I suspect this type of plasmapheresis equipment is something Bryan Johnson will soon have at his home, with regular fresh plasma deliveries (like milk to the doorstep in the 1950s 
)
Plasmapheresis Cost:
The cost of Plasmapheresis is quite high. Per session of this method can cost anywhere between five thousand and ten thousand dollars in the United States. In some cases, this process may be required to be carried out repeatedly. It will help if you have a medical insurance to take care of the costs.
From: Plasmapheresis - Ask Hematologist | Understand Hematology
和：
Results
The direct cost of five IVIg infusion sessions totaling 2.0 grams per kilogram (g/kg) body weight was $10,329.85 compared to a series of five TPE procedures, which had direct costs of $4,638.16.
source: Cost-minimization analysis of the direct costs of TPE and IVIg in the treatment of Guillain-Barré syndrome | BMC Health Services Research | Full Text
Today, apheresis is available to patients in some physician practices. With equipment priced at $50,000 or more per machine, disposables costing between $1,500 and $3,000 per patient, plus the cost of adding highly trained professionals to oversee the procedures, apheresis is not something that every office practice can afford to or should offer. However, when office practices find it financially feasible to provide apheresis services and have the required office space and patient volume, it can be a good option for patients and a self-supporting business for the practice.
Source: Apheresis in the Office Setting - PMC
Full analysis here from a UK clinic here:
Convalescent-plasma-A-costing-review.pdf (509.6 KB)
The Apharesis equipment market seems to be about a $3 Billion market already:
Key Companies & Market Share Insights
The market is oligopolistic in nature and is marked by an extensive presence of mergers and acquisitions. New product developments, acquisitions, and strategic alliances are some major sustainability strategies adopted by industry players. For instance, in October 2020, Haemonetics received US FDA 510(k) approval for its NexSys PCS system with Persona technology. In January 2020, Fresenius Kabi spent EUR 30 million in order to build an apheresis and transfusion disposables plant in the Dominican Republic. Some of the prominent players in the apheresis equipment market include:
- B. Braun Melsungen AG
- Haemonetics Corporation
- Fresenius KabiAG
- Asahi Kasei Medical Co., Ltd.
- Terumo BCT, Inc.
- Mallinckrodt
- Nikkiso Europe GmbH
Source: Apheresis Equipment Market Size & Share Report, 2030
