#846

Might be getting high off the messianic feeling. I don’t think we should underestimate the usefulness of it. I think that can sustain anyone on a restrictive regiment, diet, supplements, and health lifestyle. We all feel the valence looking at a hero in a movie, but imagine being him. Of course from the outside you don’t feel it nor does it make any sense, and you don’t see him that way. I honestly think he feels like he is a prophet. With the right amount of psychedelics (Bryan has a tattoo of 5-MeO-DMT, the most powerful psychedelic, see this Ayn Rand fan wanting to live to 200 years) and or high schizo polygenic score, anyone can feel it too, with some work, as well, of course.

I wonder if Michael Lustgarten feels this too.
I can choose to forgo diet and lifestyle, and just live normally and take a statin. Or I can become a health optimizer and ‘figure things out’, that no one else has, and be extraordinary. The end result might be the same, but the experience entirely different. Even if you fool yourself your entire life, you lived thinking you were a King. And that might be worth it. :rofl:

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#847

Then again, when have people ever cared about science? What we need is public interest → money → research → significant life extension in dogs and monkeys → even more money and interest.

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#848

If one makes others believe he’s a King, then he IS a KING.

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#849

He already has followers, a shame, since they miss the point. At least he’s helping them get healthier.

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#851

@AnUser Bryan Johnson has now entered his 16th minute of fame.

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#852

He keeps getting it. Longevity is going mainstream. As evident by the million copies sold of Peter Attia’s Outlive.

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#853

Attia, Bryan and Sinclair are all very different and it’s hard to compare them. Of the 3, Attia is the most practical and I think he has the best ideas for stuff that’s not too far out there. Sinclair is doing moonshots, but if it works, it’ll change the world. Bryan is proving the principle of living longer. All 3 have unique approaches and all 3 are needed to move longevity science forward, IMHO.

And let’s not forget @RapAdmin This forum pushes ideas forward as well. I’m always pleasantly surprised when a luminary mentions Rapamycin.news. I am pretty sure all of the three above have visited here at least once.

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#854

TL;DR His whole life he thought that when he died he’d go live on his own heavenly planet for eternity, along with his kids and sister wives. So he had the afterlife handled. One day he came to realize that’s bonkers and had no backup security blanket re: his own mortality so he got it into his head that he should (and would) never die. Now he gets to live in his own earthly planet with his one kid and Asian sister-girlfriend. Looking for acolytes to maybe do the dishes. :smirk:

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#855

I don’t think it ever was not mainstream. Eternal life, fear of unknown, death, ending is the primary human experience since the beginning and is forming society, religion and personal psychology.
Accepting the inevitable is far more difficult than defending against it.

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#856

what are they missing?

#857

@scta123 There’s a good documentary on HBO Max that shows how naive and gullible people can be. It’s called “Mother God,” and it’s about a woman in her early 20s who abandons her three children to establish a commune in Colorado that quickly becomes a cult. All of the cult’s adherents are completely in thrall to her and parrot her talk about “galactic energy,” as if it were a principle taught in physics books. The Mother God ultimately dies of poisoning from drinking too much alcohol and colloidal silver. The only skeptic in the bunch, who has kept his doubts to himself, takes off with the money the cult has earned from donations and such, more than $300,000. The End.

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#858

It does seem to be going that way. I was quite critical of him when he first appeared, which I think was remiss of me. But, one of the points I made was that this might all just flame out and he’ll end up becoming just another biohacking influencer because it’s still way too early. So while I commend Bryan and believe it’s really helpful for him to raise awareness and get the average person talking about Longevity, adopting his protocol isn’t going to move the needle. Eating lentils and getting eight hours sleep a night might be healthy, but Blueprint essentially just becomes another fitness club and no doubt, a pissing contest. I don’t have any issues with him selling food and supplements and then asking people to take tests, because it’s a great way of getting data. Bryan is in some ways a visionary. The idea that you can create an algorithm that takes care of you is better than you can, is smart, but it’s not possible with our current technology. I think this is all destined to implode when people realize that no amount of Kale smoothies are going to deliver real results. For all of Byran’s good intentions his followers are going to end up sorely disappointed.

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#859

Wonder if his followers will start reading up on rapamycin, acarbose, etc

and also gene therapy, etc

also?

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#860

I’m sure they will, and that is a good thing. Bryan is a net positive for the space, and for me he’s a sign that there’s momentum building. I sincerely wish him every success. I’ve been interested in longevity science for years and despite my optimism I’ve come to realize we’re very far from anything substantive that is going to make a real difference, but at least it’s finally becoming a mainstream idea. However, none of that takes anything away from Byran’s effort, at least he’s trying to put something together that ‘could’ work. Longevity is still very much stuck in the bench science phase, which doesn’t help anyone.

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#861

I’m a bit more bullish, but agree that there is a range and probability that things do go slowly.

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#862

I’m pretty bullish on the technology, I’m just less convinced the general public will have access to them any time soon. There are some potentially groundbreaking treatments on the horizon. but there’s a huge bottleneck in translating them to the clinic, and that’s because of the amount of time it takes to get new drugs to market. I think the average is about 13 years. I’m pretty convinced there are treatments available that could extend lifespan now, but it’s going to take so long to prove it and make it available that most people will miss out.

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#863

Do you have any insight as to why CRISPR activation hasn’t taken off? It would alleviate the DSB-related issues and also has the advantage that you can simply stop administering it if side-effects arise.

It seems like delivery is still an issue in practice, as I can’t find any papers reporting using lipid nanoparticles, although it has been done with AAV.

That to me seems like our best option for harnessing potential longevity genes (VEGFA, FGF21, TERT, etc)

Edit: Funny enough, the above paper was first to use CRISPR activation to alter a phenotype postnatally, and they did this by inducing follistatin to increase muscle mass.

It seems like this company MiniCircle is just using lipid nanoparticle-encapsulated plasmids though.

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#864

My stock portfolio also wonders that! :sweat_smile:

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#865

The problem here is like having a hammer and some nails, but not knowing where to put the nails.

We dont know what genes to modify.

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#866

Is there someplace I can find out exactly what the “67 interventions” with out signing up for the program?

1 Like