#685

It doesn’t seem very accurate according to people on reddit, so I am skeptical.

#686

ok, thx for color. if you Bryan/Oliver more questions perhaps you could ask them

  • how did/do they use Foodmarble
#687

Their discord is here if you want to ask, I don’t know when the next Q&A is though.

2 Likes
#688

Thx. I signed up. Appreciate it.

#689

It just works.

Good video.

5 Likes
#690

A deep thread :thread: re gaps/improvements to Blueprint

A lot I don’t agree with here, but still a lot of food for thought:

https://twitter.com/chrismasterjohn/status/1736166271517962392?s=46&t=zJMJ1xVdRJYEDYz-DHipTw

4 Likes
#691

I was going through his supplement stack and found Bryan supplements with Tyrosine. I find this odd as it is an amino acid that increases with age and supplementation seems to be beneficial only to those under a lot of stress (maybe he is?) It can also promote the development of T2D. Not what I would want.

Tyrosine, a non-essential amino acid, is both glucogenic and ketogenic and is synthesized from phenylalanine by the phenylalanine hydroxylase enzyme. Tyrosine is the precursor for the neurotransmitters dopamine and norepinephrine. In a metabolomics study of human plasma, tyrosine and glutamine levels increased with age, while histidine, threonine, tryptophan, leucine, and serine decreased with age [359]. Supplementation with tyrosine in both hypertensive humans and rats led to a decrease in blood pressure [360]. In one study of human subjects, increased dietary tyrosine levels were linked with increased cognitive performance [361]. However, another study found that supplementation of moderate tyrosine levels had no effect, while high dietary tyrosine levels decreased cognitive performance in older adults [362]. Authors of a recent review suggest that tyrosine supplementation likely only increases cognition during times of stress when either dopamine or norepinephrine levels are depleted [363]. There is no consistent data that tyrosine supplementation can decrease the effects of stress on cognitive or physical performance [364]. Tyrosine supplementation has been shown to increase the vasoconstriction response to body cooling in older adults, so it may aid thermoregulatory function [365]. Tyrosine supplementation has been shown to enhance dopaminergic neurotransmission in Parkinson’s disease patients [366]. However, high levels of tyrosine in the plasma increase the risk of type 2 diabetes to a similar extent as increased levels of each of the three BCAAs [33]. In C. elegans tyrosine supplementation increased lifespan moderately at the lowest 1 mM dose, but only slightly at the two higher doses (Table 1) [3].

3 Likes
#692

This one was a good find from Blueprint. It’ll cut my cost in half for this supplement:

Nutricost Zeaxanthin with Lutein 20mg, 120 Softgels - Potent, Non-GMO, Gluten Free

http://www.amazon.com/gp/product/B07Y2H11DP/ref=ox_sc_act_title_1?smid=A2YD2H3KGK1F4L&psc=1

1 Like
#693

I have to throw in my n=1 that BioMin F is amazing. My teeth are no longer sensitive and the surface of my teeth feel smooth and hard. Haven’t had one cavity since I started.

3 Likes
#694

When did you start with BioMin?

#695

Bryan Johnson doesn’t seem to be using Glycine.

#696

It’s in his collagen I think?

1 Like
#697

How much glycine would that be?

#698

Think it says in the blueprint protocol website, if you can’t find let me know and I’ll try after work

#699

He takes 25g of collagen peptides, and glycine is about 25% of collagen. So 6.2g of glycine.

4 Likes
#700

Actually, it’s about 25-33% of glycine in collagen, so about 6.2 - 8.33 g of glycine daily.

Even though you can synthesize it, your body runs in a depleted state after the age of 40-45 as your body cannot produce enough and it only gets worse as you grow older. Therefore you need to start supplementing at 40 and slowly increase the dose. My rule of thumb is your age/10 grams daily minimum. I don’t think they’ve tested safety for glycine above 20g daily, but I would say you could probably go up to 25-30 without a problem.

Glycine, which is 33% of collagen residues, has been typically classified as a ‘non-essential’ amino acid because human metabolism can synthesize it from serine.

4 Likes
#701

Hi, i may have this wrong, but i think glycine is 33% of the amino acids in collagen. But because it’s mass is lower than the other amino acids it’s 25% by weight:

“Collagen hydrolysate has 33% glycine residues (25% of its mass), so 10 g of hydrolysate (the daily dose used) means 2.5 g of glycine, which is insufficient for the metabolic needs.”

4 Likes
#702

The Sensodyne toothpaste in USA does not contain NovaMin - it does contain stannous flouride though, so that was probably what Bryan used before, now he probably uses BioMin.

According to BioMin the apatite formed by flouride is 10 times better than the one without for resisting acid, so it’s simply worse to use the flouride free toothpaste in this regard.

2 Likes
#703

Did he end up being there / you end up meeting him?

#704

No, he was a no show. I have no idea what happened.

1 Like