#326

This is the Mannick 2014 trial with everolimus (similar to rapamycin):

image
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Thoughts?
mannick2014Everolimus.pdf (354.2 KB)

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#327

Absolutely false, I never attacked your decision. I made a general comment on this forum NOT TO YOU and you strongly disagreed. Now it makes sense why that comment triggered you.

jnorm

26d

Frankly, I don’t understand why a healthy 20 year or even 30 year old would want to use rapamycin…

The same reason anyone else here would want to use it—slowing the aesthetic and functional changes associated with aging. Does every piece of data support taking rapamycin from a young age? No. That said, it still seems riskier to not take rapamycin.

Sure, you could stick to exercise, eat clean, socialize, avoid environmental toxins, manage stress, etc, but to me those things go without saying. And they aren’t going to move the needle past the existing lifespan limit anyways.

The whole exchange is on this forum, the initial time I disagreed with you was on the significance of Brian Johnson looks. Go back and re-read the thread.

#328

I understand it well enough not to take arbitrary p-values on faith. I have also know how easily studies can be manipulated by inclusion or exclusion criteria, end points, etc.

Answer this question: Is there scientific proof that ONLY set p-values of 0.05 or 0.01 are clinically relevant in medicine?

Clearly you are not a clinician. In medicine there is a wide use of anecdotal evidence because frankly we do not have double blinded placebo studies to prove to a with 95% (or 99% :roll_eyes:) confidence that every aspect of medicine performed is valid.
Is there a scientific proof that palpating cervical lymph nodes leads to better diagnosis?
Is there scientific proof that using that stupid paper on exam table actually protects patients from any nosocomial infections?
Tons of medical guidelines are based on expert opinions as well as results of multiple studies.

Anecdotal evidence is still evidence, WEAK evidence but evidence nevertheless.

If you a doctor that prescribes rapamycin and after several months patient develops 2-3 subcutaneous infections , he returns to you and says “Hey doc I think this rapa is causing infections”
What are you going to say to him?

It is not a known risk for intermittent usage in healthy individuals. That is a false statement

And when this patient dies from sepsis after another skin infection, what do you think the jury will decide ?
A. There is no scientific evidence thus the doctor is not guilty of medical negligence.
B. The patient clearly communicated that he’s having an issue with a drug, why didn’t use your common sense doc?

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#329

My N+1, your mileage may vary:

Melanoma in Situ after 3.5 years on rapa (various protocols, initially 6mg/wk, now 8mg every 2 wks).

Healthy, athletic 60+ woman w lots of sun exposure, no family history.

Are you on rapa? Do you have sun damaged skin? Then please, get a skin scan every year at least.

I’m sticking with the program.

Onwards!

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#330

Significant sun exposure during early childhood is a major risk factor for developing melanoma later in life. I imagine the seeds for that melanoma were laid decades ago.
At least you caught it early. Pancreatic cancer and melanoma are two cancers I fear the most.

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#331

There was no disagreement there since I jokingly commented he looks “50 going on 15” cause of the way he was posing. That clearly went over your head though and you felt the need to go on a tangent about “be careful judging people online because of their looks… blah blah blah”

#332

OK guys - please try to keep on-topic. Online its easy to mis-interpret people’s intentions because we lack a lot of context, so best to assume the best intentions of the other party.

Back to our regularly scheduled program…

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#333

You are correct, I am not a clinician. I was a PI in the research group for DuPont for 40 years and the last 10 taught newly hired PhD’s experimental design and statistics - which are woefully neglected in academia.

Your statements about the meaning of p values is laughable and clearly you don’t understand what a null hypothesis is.

The medical profession over the centuries has been wrong about most things, often barbaric in their treatment and more akin to voodoo than science, so I don’t buy your arguments.

If I were a doctor (which I am not) I would be humble enough to be open minded to any possiblity certainly but would not advise someone based on my arrogant pseudo knowledge of a field for which I was not trained.

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#334

Let me mirror that back at you, so you can listen to your own advice…
If I were a bench scientist (which I am not) I would be humble enough to be open minded to any possibility certainly but would not advise someone based on my arrogant pseudo knowledge of a field for which I was not trained.

I don’t discount the scientific method but I find your complete disregard for anecdotal evidence perplexing. Sometimes the scientists are so obsessed with the “method” that they forget about common sense. Just because there is on scientific proof of an effect, it doesn’t mean that it doesn’t exist.

It’s also just mind blowing that yet you somehow end up taking sirolimus in spite of lack of any statistically significant positive effects in human trials. It looks you selectively apply the scientific method to make life’s choices.

#336

Godwin’s Law alert! I think this exchange is now officially over.

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#337

Scientist vs. Doctor :popcorn: :popcorn:

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#338

I am outspoken, hit a nerve, get attacked and end up defending myself. Story of my life :rofl:
Being meek got me nowhere in my life, so now it’s full steam ahead.

Science got too entrenched in its orthodoxy, people don’t take kindly when you challenge their religion.
L. Ron Hubbard knew this too well and exploited it well.

Technically 99% users on these forums are science heretics with your rapa protocols, methylene blue, etc. :joy: :joy: :joy:

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#340

I take rapamycin based on ITP studies (Which are extemely well designed and analyzed) - no human studies are available - which is true for 99% of what I do -

I am not the one giving advice to anyone about what they should do based on a non-scientific survey - that would be you

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#341

When you put a Dr in front of your name, you should have a higher standard. People look up to doctors as experts. Stating something as a fact that is not provable is misleading and not up to ethical standards IMO.
If you were just Bart, I would have ignored your comment

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#342

Sigh.

  1. Giving medical advice on internet is the last I would do as an MD. Let’s just be clear I state my opinions and NOT give ANYONE any medical advice. Legal compliance has drilled that in to my head for the past 25 years.

  2. It is my opinion that extrapolating from very well designed animal studies while completely ignoring anecdotal data from surveys or personal reports of n1 human trials is neither scientific nor makes any freakin’ sense.
    But you do you.

1 Like
#343

I am a big fan of calculating effect size and confidence intervals in comparing and contrasting treatment effects. This very short article is a good introduction as to why.

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#344

Some may think I am crazy for ignoring anecdotal data and bogus survey data, but 40 years of running lab and manufacturing experiments have taught me that this type of information is often misleading and the cause of many poor decisions. I find it is best to ignore it and focus on gathering actual data on my body. There were so many instances where teams I was on went down rabbit holes that cost the company millions of dollars because of an anecdote. There is such a strong bias among humans to think anecdotes are real when in reality they are just noise - sigh

When I look at an intervention, I look to scientific literature of well designed studies that may indicate efficacy in life extension. If a drug that is FDA approved I will test on myself, but here is where I may differ from others.

I have recorded on a spreadsheet my biometric data every day for the past 5 years - things like BP, RHR, HRV, BG, reaction time, grip strength, sleep data, temp, weight, BF
In addition, I do extensive blood work every quarter. I can analyze the effect of any intervention quite well - much like Mike Lustgarten.

In my experience this is a far better approach than asking others or doctors what I should be doing.

But, you do you as the doc says. Good luck with that.

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#345

Congratulations on the consistency, I wouldn’t last 5 weeks collecting such data, maybe not even 5 days!

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#346

Mike Lustgarten have said he really enjoys typing it in all manually in a spreadsheet and trying to discover new things. We’re all wired differently.

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#347

“We’re all wired differently.”

Nice way to acknowledge those on the spectrum… they can’t understand what they can’t comprehend due to neurological make up.

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