#313

I’m not backtracking. You’re the one repeatedly bringing up 20 y.o.'s which is why I clarified that I’m in my 30’s.

#314

Our discussion was always about 20 year olds.

BTW, on what evidence did you use to justify starting rapamycin as a 30 year old ? .
What was the p-value in the study that proved benefit in 30 year old humans using rapamycin?
Don’t kid yourself, you are using mainly anecdotal evidence, one paper that doesn’t even apply to you and lots of bro science.

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#315

I have a bacterial skin infection right now which has probably been made exceedingly worse by being on Rapamycin. It’s cellulitis caused by 3 mosquito bites on my arm. Normally, they probably wouldn’t get infected, but that’s a downside of Rapamycin. It’s not going to kill me, but boy oh boy does it itch. My forearm is incredibly swollen.

FYI, I do blame every bacterial infection I get nowadays on Rapamycin. :stuck_out_tongue_winking_eye:

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#316

Well, my guess that most people on these forums are already maximizing their health via conventional ways - proper diet, sleep, exercise, some supplementation. So in essence most people here are pretty healthy in comparison to their peers…but healthy people don’t usually get skin infections unless they have poor circulation or diabetes.
So, yes, blaming it on an immunosuppressant is reasonable.

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#317

Anything I’ve said is only in defense of my own decision to take rapa, which you attacked early in the thread. I have zero incentive to defend a 20 y.o taking rapa, even if the logic might be similar.

BTW, on what evidence did you use to justify starting rapamycin as a 30 year old ? .

First and foremost the lifespan and healthspan studies in rodents and now marmosets, the same reason mostly everyone else here is using.

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#318

I do, too. And my own similar infections have created a limit on my use of rapa, which is why I’m so excited about the possibility of lysine being my answer. I’ll be trialing that again on my next round of rapa.

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#319

Maybe I’ll try Lysine the next time I get an infection or an outbreak of hives to see if that helps.

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#320

From my own experience Lysine is only anti-viral. and will do zilch against bacterial infections. So pretty much it depends on source of infection.

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#321

Yes. I think the hives could be viral, so lysine may help with that.

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#322

I’m sure it does if it is viral, but don’t underestimate the synergetic effect when combined with Vit C (for maximum effectiveness). From my experience either alone is nowhere near as effective as when combined.

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#323

I always take extended-release vitamin C 1 g daily at night.

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#324

unfortunate that you do not understand statistics and experimental design.
It is not a known risk for intermittent usage in healthy individuals. That is a false statement
Major problem with this “study” is it is unblinded survey from biased users who are familiar with data from immune suppressed .
Would need a placebo controlled double blind experiment to even begin to know enough to make statements about what intermittent usage does.

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#325

Thanks, I will keep this in mind if this becomes an issue, while trying to figure out a possible cause of course. I cannot remember ever suffering large furuncles (~1.5 - 2 cm). I did go through a phase during puberty where I had mild acne on face and back that would occasionally result in a carbuncle or single furuncle, but never that big as far as I can recall. Also, FWIW, the three purulent explosions I experienced were located in unusual areas, for me anyway, anterior shoulder, scrotum (!), and just above a clavicle.

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#326

This is the Mannick 2014 trial with everolimus (similar to rapamycin):

image
image911×652 58.8 KB

Thoughts?
mannick2014Everolimus.pdf (354.2 KB)

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#327

Absolutely false, I never attacked your decision. I made a general comment on this forum NOT TO YOU and you strongly disagreed. Now it makes sense why that comment triggered you.

jnorm

26d

Frankly, I don’t understand why a healthy 20 year or even 30 year old would want to use rapamycin…

The same reason anyone else here would want to use it—slowing the aesthetic and functional changes associated with aging. Does every piece of data support taking rapamycin from a young age? No. That said, it still seems riskier to not take rapamycin.

Sure, you could stick to exercise, eat clean, socialize, avoid environmental toxins, manage stress, etc, but to me those things go without saying. And they aren’t going to move the needle past the existing lifespan limit anyways.

The whole exchange is on this forum, the initial time I disagreed with you was on the significance of Brian Johnson looks. Go back and re-read the thread.

#328

I understand it well enough not to take arbitrary p-values on faith. I have also know how easily studies can be manipulated by inclusion or exclusion criteria, end points, etc.

Answer this question: Is there scientific proof that ONLY set p-values of 0.05 or 0.01 are clinically relevant in medicine?

Clearly you are not a clinician. In medicine there is a wide use of anecdotal evidence because frankly we do not have double blinded placebo studies to prove to a with 95% (or 99% :roll_eyes:) confidence that every aspect of medicine performed is valid.
Is there a scientific proof that palpating cervical lymph nodes leads to better diagnosis?
Is there scientific proof that using that stupid paper on exam table actually protects patients from any nosocomial infections?
Tons of medical guidelines are based on expert opinions as well as results of multiple studies.

Anecdotal evidence is still evidence, WEAK evidence but evidence nevertheless.

If you a doctor that prescribes rapamycin and after several months patient develops 2-3 subcutaneous infections , he returns to you and says “Hey doc I think this rapa is causing infections”
What are you going to say to him?

It is not a known risk for intermittent usage in healthy individuals. That is a false statement

And when this patient dies from sepsis after another skin infection, what do you think the jury will decide ?
A. There is no scientific evidence thus the doctor is not guilty of medical negligence.
B. The patient clearly communicated that he’s having an issue with a drug, why didn’t use your common sense doc?

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#329

My N+1, your mileage may vary:

Melanoma in Situ after 3.5 years on rapa (various protocols, initially 6mg/wk, now 8mg every 2 wks).

Healthy, athletic 60+ woman w lots of sun exposure, no family history.

Are you on rapa? Do you have sun damaged skin? Then please, get a skin scan every year at least.

I’m sticking with the program.

Onwards!

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#330

Significant sun exposure during early childhood is a major risk factor for developing melanoma later in life. I imagine the seeds for that melanoma were laid decades ago.
At least you caught it early. Pancreatic cancer and melanoma are two cancers I fear the most.

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#331

There was no disagreement there since I jokingly commented he looks “50 going on 15” cause of the way he was posing. That clearly went over your head though and you felt the need to go on a tangent about “be careful judging people online because of their looks… blah blah blah”

#332

OK guys - please try to keep on-topic. Online its easy to mis-interpret people’s intentions because we lack a lot of context, so best to assume the best intentions of the other party.

Back to our regularly scheduled program…

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