#168

Both low and high IGF1 are bad and undesirable

I’ve posted studies in another thread regarding the topic but here is Liner AI’s summary

“The optimal level of insulin-like growth factor 1 (IGF-1) for adult men can vary based on several factors, including age, health status, and the specific health goals. However, general guidelines exist to help determine the optimal range.

Optimal IGF-1 Levels

  1. General Reference Range: For adult men, the optimal serum IGF-1 levels typically fall within the range of 100 to 300 ng/mL. Within this range, individuals may experience various health benefits related to growth, metabolism, and overall hormone balance.

  2. Age Considerations: IGF-1 levels naturally decline with age. For example:

    • Younger adults in their 20s or 30s may have higher levels, often approaching or exceeding 300 ng/mL.
    • In contrast, older adults may find their optimal range closer to 100 to 200 ng/mL, reflecting the normal physiological decline in growth hormone activity.

  3. Health Implications:

    • Levels below 100 ng/mL may indicate growth hormone deficiency and could be associated with muscle loss, increased fat mass, and decreased energy levels.
    • Conversely, levels significantly exceeding 300 ng/mL may be linked to increased risks of certain cancers, cardiovascular issues, and insulin resistance .

Conclusion

In conclusion, adult men typically aim for IGF-1 levels in the range of 100 to 300 ng/mL for optimal health, with individual considerations for age and specific health conditions. Regular monitoring, particularly if undergoing treatments influencing growth hormone or IGF-1, is essential for maintaining these levels within a healthy range and minimizing potential health risks. Engaging with a healthcare provider for personalized advice is also advisable.”

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#169

“General range” (from conventional) and “optimal” (from longevity optimization perspective” do often not go well together

General would be too high Apo B/LDL, too high HbA1c, zero rapa, zero CRON, zero ever fasting, et

Of course way too low IGF1 probably not good for longevity either, but other data suggest that normal range may not be optimal for longevity (for near term strength, vitality, etc is a different case), and def not getting it to the higher range via HGF it seems

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#170

I don’t really follow him either :slight_smile: I’m much more interested in science that celebrities. My take on Renuva, after reading a couple of studies, is that it is safe and may be very effective with one caveat, though. People in studies have BMI 23–35, which indicates to me that if you have a lower BMI than that you results may not be there. Renuva MOA is that it provides acellular matrix, which allows for adipocyte migration and infiltration. I have seen Renuva marketed by some (not by MTF Biologics, maker of Renuva) without a shred of evidence as a way to address gaunt face for a very thin folks who don’t have enough fat of their own for fat grafting. I’m actually quite curious on whether it actually does anything for people with < 23 BMI, besides of course depleting their savings account… If it does, it would be very good as I know e.g. that some people with HIV could benefit from it.

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#171

Only if the evil deathist wizards aren’t defeated by Anduril once they come to take away our headless clone farms.

Circa 2072, celebratory festival :mirror_ball: :man_dancing: at the first free city-state of Nelwyn, home of the Longevity Community, after successful head transplants into low IGF-1 optimized headless clones (with genome editing help from the Jiankui He Lab Inc, of course):

Anyone up to become the Little People of Nelwyn? @ng0rge? Or will you remain a giant?

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#172

This is very interesting, many healthy people over 50 seem to have a 3:1 ratio in favour of neutrophils, within the lower ranges of normal for both. I’d be interested to understand how to improve the ratio towards equality?

#173

@JazzMann That question, I gave my best response to on a topic here:

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#174

How did you come up with 10mg every 3 months? Would it be better to do one 60 to 90 day cycle a year? On the cycle take 6-9mg a week? Then cycle off it it for the rest of the year?

#175

AIUI the issue with Rapamycin is ensuring it is very low for a period of time.

1 Like
#176

Where can we get topical fisetin?

#177

We have to make our own. Maybe with DMSO.

#178

I wasn’t seeing any benefit and the reason I did 10mg every three months was because I still have plenty left, and just in case it might help. However, I’m going to switch and do low doses 1 or 2 mg every few days and see how it goes. while many believe that high doses weekly or biweekly is the way to go there hasn’t really been a consensus with regards to dosing. again, I did NOT feel any benefits that I can attribute to RAPA so I’m still experimenting.

#179

Fascinating! I found these two resources that may be useful to others:

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#180

I take 2mg of rapamycin a week (2 of Rapamune 1mg) and I feel really good. The day I take rapamycin, I reduce my calories a lot. and I have experienced most of the benefits mentioned in the forum. So low doses are also really effective. High doses can be risky.

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#181

I’m not far off from a similar conclusion to Bryan Johnson. Rapa’s effects on lipids and glucose tolerance in me are rather profound. I can’t justify elevated lipids and glucose for theoretical benefit unfortunately. I have seen some benefits as listed below, but hypercholesterolemia and glucose intolerance likely outweigh the benefit of these. I’m doing some serum drug level testing to see if perhaps levels are too high leading to the side effects, but even at 3mg/wk I develop elevated LDL and glucose.

Benefits

  • MCV was always slightly high. Rapa corrected this.
  • I’ve always been slightly thrombocytopenic. Normalized s/p Rapa.
  • CRP has always been <1, but reached lowest (0.34) on Rapa
  • NLR (just because we are discussing) is 1.25

Neutral

  • No perceived improvement in how I feel, sleep, cognition, energy, chronic injuries (knee arthritis, chronic bilateral hamstring tears, mild disc disease)

Negatives

  • elevates LDL. Prior to Rapa (most recent testing) LDL was 66 on Repatha. Post Rapa increased to 107. no change in HDL. Peak LDL was 124 on Rapa w/o Repatha.
  • elevates fasting glucose to >100. Consistent with multiple dosing regimens and confirmed on CGM. My normal fasting glucose is ~80. No baseline glucose intolerance with A1C 4.9-5.2 and HOMA-IR 0.4-1.

Very intriguing medication and I was hopeful I could work around the side effects, but haven’t found a way to do so. Will do drug testing at 2mg/wk and see if perhaps levels are higher than expected for that dose. I don’t take any strong CYP3A4 inhibitors, but eat a lot of black pepper which inhibits p-GP. Not sure how much effect that is having.

11 Likes
#182

What I like about the large dose cycling with testing is that you see the various biomarkers move around. Hence glucose initially goes up and then comes down and similarly WBC go down and back up.

At the moment I am planning another 22+GFJ on 8th December. I see no reason not to do this.

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#183

Am I missing something, or does Bryan’s [5] study that he references actually say the opposite of what he’s claiming? I understand this study as saying that rapa consistently decreases epigenetic age across multiple DNAm biomarkers . https://www.biorxiv.org/content/10.1101/2024.10.22.619522v1.full.pdf

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#184

Let us know what happens when you have the data.

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#185

Ok here is a massive study narrowing the range down further and concluding that 120-160mg IGF1 to be the optimal range for lifespan.

“In conclusion, by analyzing and comparing different ranges of IGF‐1 in 30,876 subjects, we find that both high and low levels of IGF‐1 increase mortality risk, and for the first time, we identify a specific mid‐range being associated with the lowest mortality (120–160 ng/ml). Using the NHANES III survey, we show an association between high intake of animal proteins, carbohydrates, and milk‐based products and IGF‐1 levels. These results can point to diagnostic, nutritional, and pharmacological strategies to optimize IGF‐1 levels and help reduce mortality.“

7 Likes
#186

This is why I love this community

#187

Sorry to disappoint you LOL but thought we were talking about current number which is 8+ close enough to 10