LaraPo
#124
It’s an interesting presentation. BJ’’s Don’t Die concept is not new. Existence has always been the highest priority since the dawn of our species. BJ simply elevated the concept to a new level supported by a renewed interest in longevity. Good timing! Old concept. It gives direction to many in the chaos of everyday life.
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On his webpage he mentions various blood biomarkers. His LDL is 74, HDL 73, 158 Total Cholesterol. His list of supplements includes Red Yeast Rice, which lowers LDL (natural statin)
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adriank
#126
It will be funny in the next 20 years when they discover that some of his methods are wrong… which has happened to many stuff before such as eating eggs… The more I read about him the more I think he is a salesman like David Sinclair… selling snake oil… I have no idea why people are so adverse about dying… I am more interested in staying independent. I am sure many of you are aware you can “die” in your sleep just by asking for it when it is nearly the time.
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I disagree. I think Bryan Johnson truly believes in what he is doing and if science changes its mind, he will too.
Of course, he’s also trying to cash in on it as well as any good American capitalist would. 
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I think both @adriank and @DeStrider are right in a way.
The combination of massive amounts of items that are likely working on the same pathway is wasted, who knows if counter productive, given the typical pattern of a sweet spot in the middle and going to a high dose might worsen outcomes.
Then interactions between items that cancel each other out or together result in a worse outcome than nothing is a risk.
It’s going to be complicated to figure all this out, if not impossible.
I’m adverse to dying, until the time is right. So doing the sensible things to avoid this, and health complications is my focus. Getting to 100 and able to hike, and be mentally intact … that’s a win. Being demented and sarcopenic with poor quality of life is what most of us think about when we talk about 100 years old.
However, for those of us doing a whole number of things to slow aging and risks - is our 100 going to be totally different than this? That is the hope, assuming we even make it there.
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I think he sees himself as some form of religious or political leader as well.
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There is an argument, however, that they would be additive to a point, but the side effects from them would vary so that they would not be additive in the form of side effects.
That’s why I take a combination of HDAC inhibitors. The total HDAC inhibition should be additive, but the side effects should not.
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Biohackers are so f**cking stupid sometimes. Supplements good because natural. Medication bad because not natural and some schizos complain about them on reddit. But rapamycin and acarbose also good because not popular so less schizo complains and work in mice.
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AnUser
#133
I feel like Longevity like other fields is many times more of an Art rather than a Science, there’s no way there are large randomized controlled trials for everything that’s way too expensive. So basically we just have to go for it what we think make sense and measure things on the way. Even if you had RCT’s for everything they are still just measuring the average response.
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Randy
#135
How good is divalproex as Hdac inhibitor in your experience
I don’t use Valproate. AIUI it operates in the nanomole range. I tend to use those in the micromolar range. It is possible to overdo HDAC inhibiition. That is easier to achieve with stronger ones.
divalproex = sodium valproate and valproic acid
1 Like
medaura
#137
Just popping in here to say that I own two of the modalities he used in this video:
Shockwave and EMTT. Haven’t yet used the shockwave device yet as my ankle seems fully rehabilitated. But I did use the EMTT and it helps immensely. Mine is actually a later gen version than the one he’s using — I recognize it from my Chinese vendor. It’s PEMF and EMTT in one, which are the same thing really, except the range of electromagnetic frequencies used for EMTT are a very high subset of what would be considered PEMF. It was so frustrating being pregnant with the sprained ankle as it was strongly counter indicated — though I still used it a handful of times when I was in deep trouble. After delivery it was key to my recovery on that chronic ankle problem. By the time I got the shockwave device it had already healed so I’m keeping it for “next time.”
My husband hates the PEMF / EMTT device because he’s a wuss and gets scared by the involuntary muscle twitching. If anything he probably gets a nocebo effect from it and always says I must be doing some damage when I use it. But he has had a nagging rotator cuff problem of late that’s preventing him from doing pullups and out of desperation let me use it on him. Even he had to admit the shoulder felt a bit better the day after. This was literally last week so we’ll do it again today or tomorrow.
Bottom line, some of this stuff truly works. I’ve personally had great success with TECAR also as an adjunct to PEMF / EMTT for my ankle.
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Beth
#139
As a WFPB person, that all looks outstanding to me and thx for the cheat sheet.
Because you don’t love the taste, I wanted to share this recipe that is reminiscent of that chickpea dish you shared incase it was of interest on the days you want to put in a little more effort. It’s still very easy and it’s an ‘OMG I CAN’T BELIEVE I MADE THAT’ level of good
I made it with the correct amount of EVOO once and it was OTT… if you have no problem with sat fat, I highly recommend it. For me, I need to use significantly less… not as good, but still good.
I used non dairy yogurt. Also, you can skip that entire step. (it’s really good, though!)
Fwiw, my breakfast is fairly similar. I usually use homemade soy yogurt instead of pea protein (it’s the easiest thing in the world to make and i love it). I’ll use frozen or fresh blueberries, nuts/seeds etc, Ceylon cinnamon, and at time raspberries
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I’m only an hour into the 4 hour interview, but Derek “More Plates More Dates” is doing a good job interrogating Bryan on how his team selects and evaluates interventions.
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AnUser
#144
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LukeMV
#145
Not gonna lie. I’m gonna watch it.
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Pat25
#146
I was already bothered by the fact ~2 hours interviews seem to be becoming the norm, as there are so many interesting interviews/podcasts out there. Four hours: where to find the time for that? What’s next, 12 hour interviews?
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LukeMV
#147
Watching on 1.5x speed is the way to go
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