As I understand it, this is accurate when VEGF is increased alone, and is why clinical trials of VEGF administration have failed. However, HBOT also stimulates other angiogenic pathways which could stabilize VEGF induced blood vessel growth. Assuming VEGF is actually stimulated via the hyperoxia-hypoxia paradox in HBOT usage.
Related, intermittent hypoxia protocols reliably stimulate VEGF, and they do improve vascularization, again, due to stabilization by other HIF-dependent angiogenic factors.
Agreed that VEGF is probably not that useful as an isolated factor. Unfortunately measurement of HIF expression or other downstream pathways of either HBOT or hypoxia induced angiogenesis are not readily available AFAIK. (VEGF is available at labcorp)
@adssx has looked into HIF a lot elsewhere on the forum and might have more to add here about VEGF.
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Yes - thats a common statement I hear about HBOT for longevity. One group in Israel seems to have done almost all the “longevity” oriented research, so I don’t view it as duplicated yet and telomeres are not very important for aging for most of us. Here is Attia / Kaeberlein on HBOT:
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I think the point about telomeres is that telomerase that increases the length of telomeres does good things to the mitochondria. Hence if you have long telomeres you are also likely to have telomerase working to the benefit of the mitochondria.
adssx
#218
Nothing to add but I wonder if most of the benefits of HBOT come from the HIF pathway and in that case intermittent hypoxia might be better: Oxygen, hypoxia and hyperoxia
Intermittent hypoxia also seems safer, more affordable and easier to do than HBOT. But there’s not much data for the moment tbh.
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I have been doing normobaric hyperoxia followed by normoxia for a few years. I use an oxygen concentrator and do 8 mins at probably 60% ish oxygen (the oxygen concentrator claims to produce more, but once everything is taken into account it is probably 60%). That is pretty well every morning.
How Bryan Johnson, Who Wants to Live Forever, Sought Control via Confidentiality Agreements
That control is starting to fray as Mr. Johnson, a longevity guru known for performing experiments on his body, faces a backlash over the agreements.
His fame has also appeared to catapult Blueprint to success. In January, Mr. Johnson hailed his start-up as “one of the fastest-growing companies in the world, fueled by word of mouth.”
But away from the cameras, his carefully curated profile and Blueprint’s business are starting to show cracks — especially with a brewing fight over Mr. Johnson’s use of a legal document: confidentiality agreements.
For nearly a decade, Mr. Johnson has wielded confidentiality agreements to control his image and the companies he built atop that image. His employees, sexual partners, vendors and contract workers have all had to sign the documents, sometimes in exchange for settlements, severance or continued employment at his firms, according to people close to him and his start-ups, internal documents and court records.
Now those agreements, which were supposed to keep people silent on Mr. Johnson’s personal life and businesses, are backfiring as some of his workers band together to challenge them.
At least three of Mr. Johnson’s former employees — including a former fiancée who worked for him — have recently filed complaints with the National Labor Relations Board, a federal watchdog agency, about his confidentiality agreements. They said the terms they signed were “overbroad” and accused Mr. Johnson of violating federal laws that protect workers who want to speak about their workplace conditions, according to copies of two of the complaints and six people with knowledge of them.
People close to Mr. Johnson and Blueprint have increasingly chafed at the agreements as the start-up has faced mounting financial and product-quality questions that some thought should be made public, former employees and others with knowledge of the company said.
Oliver Zolman, Mr. Johnson’s longtime longevity doctor, who was featured in the Netflix documentary, quietly left Blueprint last year after having concerns about some of its health supplements, the people said. Last fall, Mr. Johnson also told Blueprint executives that the company was running out of money.
全文： How Bryan Johnson, Who Wants to Live Forever, Sought Control via Confidentiality Agreements (NY Times)
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Access to the above article through the NyTimes website … below:
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This seems to confirm what most people here know, that the biological age measures are really just marketing tools:
In the Netflix documentary, which was largely filmed in 2023, Mr. Johnson said his biological age had reversed 5.1 years. But the results of a range of internal studies of his health between January 2022 and February 2024 showed it had increased by as much as 10 years, according to charts of the blood test results. It’s unclear what his current tests show.
In an email, Mr. Johnson said that the “decision to highlight the 5.1 year reduction was made entirely by the documentary’s production team” and that the statistic came from an experiment conducted in early 2023. He said “biological age measurements fluctuate” depending on the test and other factors.
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Given that individual measurements on the same individual can vary quite a bit you can get a reduction by doing more tests and picking the lowest. How much any particular test varies I don’t know.
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What the heck is “biological age” anyway as a single number? Calendar age, yes, one number that is well understood. Let’s say that biological age is the number that would be equivalent to the calendar age at different stages - so it’s in a state that would correspond to the calendar age of the average human, your body is the average body of a 50 year old even though you are 70 by calendar age. We can clearly see that this is nonsense. There is no such single number for the whole body, the way there is a single number for calendar age. Different organs are of different age characteristics in the same body, liver 65, lungs 55 etc., and this is true regardless of your calendar age. There is no “average” body - everyone will have a different combination of ages of their various tissues. Furthermore, in reality it is much more granular than a whole organ - some aspects of a lung might be the same as in an average 20 year old while other aspects 60 year old. Even individual cells can have different age aspects. So how are you assigning a single number to “biological” age of the whole body? Based on which organ, which tissue, which cell, which cell component (f.ex. mitochondria), as all can be wildly different? It’s nonsensical and completely arbitrary.
It sounds good, until you think about it for one minute. All those companies are marketing their products based on hoping people don’t spend that minute thinking, because if people did, they wouldn’t fall for it.
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In my very first post I predicted that Bryan would flame out, as it’s all too early, which is proven as in the HBOT test he said his team were struggling to find the next therapy. There’s simply nothing out there yet we can validate to make a dent in the aging process. We can’t even measure aging probably. That said, I believe we’re close, but not close enough for Blueprint to intersect with them. So all he has left is selling supplements, testing and devices, which is a net positive for the space, but in the long term people are going to lose patience because eating broccoli isn’t getting anyone to a hundred. On top of that he recently declared Blueprint as a religion so there’s that. Not a good look in my opinion. Despite all of this nonsense, I think Bryan has raised awareness for a lot of people about what might be coming soon and I think there’s a net benefit to that.
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Dr.Bart
#226
Looks like Musely is copying Brian Johnsons formula…Prescription Skincare That Works | Musely FaceRx
Full
Active Ingredients:
- Latanoprost 0.004%
- Caffeine 0.5%
- Cetirizine 1%
- Melatonin 0.1%
Inactive Ingredients:
- 250 million exosomes
- Vitamin D3 (1,000 IU/mL)
- Vitamin E (10 IU/mL)
- Biotin (0.2%)
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To me the science is the top priority. I want to be certain as to what the truth is.
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Of course it is, but it’s going to take time and people aren’t prepared to wait. We’re a good example of that aren’t we? We’re all tinkering around the edges to see what we can do to slow things down. I still think at the core Bryan’s idea is sound, it’s just technology needs to catch up with him.
Beth
#229
Interesting to see latanoprost being used. Years ago, when latisse entered the scene, I expected to see it take over and nudge minoxidil out of the spotlight. Because it never happened, I assumed the studies never panned out .
I use minoxidil aprox 3x per week just as a preventative, and even at that dose, it does minimize shedding.
Do we know how latanooprost stacks up?
Tim
#230
If you have nothing to hide, you have nothing to fear.
AnUser
#231
Tfw you at blueprint after a signing “non-standard” confidentiality agreement
Bryan has as far as I remember always said the biological age tests aren’t accurate, that’s why he uses pace of aging.
Some examples off the top of my head that’s new or haven’t tested
- Measuring sodium storage in the body with e.g sodium MRI, correlated with diseases
- ATTR accumulation
- Drugs for above
- Testing new ITP drugs, replacing with other ones, e.g Estriol instead of 17-A-E, or trying SGLT2i
- Maybe Higher CR with GLP-1 agonist to prevent hunger (will look like elf or skeleton), (more dangerous?)
- Decreasing apoB further
- Mental tech, relating to meditation, maybe much better mental space, e.g jhana at https://www.jhourney.io/
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Neo
#232
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Dr.Bart
#233
Latanoprost, a prostaglandin F2α analogue, is known to stimulate melanogenesis, the process of producing pigment, which is why it can cause increased pigmentation of the iris and eyelashes. In some cases, this stimulation extends to hair follicles, leading to repigmentation of gray hair.
Latanoprost is a prostaglandin analog that works by stimulating hair follicles. It prolongs the anagen (growth) phase of the hair cycle, leading to increased hair density and thickness.
Efficacy:
Studies have shown that topical latanoprost can promote hair growth in individuals with androgenetic alopecia (male-pattern baldness). In one study, 0.005% latanoprost solution significantly increased hair density and reduced hair loss compared to placebo.
Dosage and Administration:
Latanoprost is typically applied as an eye drop once daily. However, some studies have used higher concentrations or more frequent application for hair growth purposes. It is important to consult with a healthcare professional before using latanoprost for hair growth.
Side Effects:
The most common side effects of latanoprost eye drops include redness, irritation, and increased eyelash growth. In rare cases, it can also cause allergic reactions.
Conclusion:
Latanoprost has shown promise as a potential treatment for hair loss. It works by stimulating hair follicles and prolonging the growth phase. However, further research is needed to establish its long-term efficacy and safety for hair growth. It is essential to consult with a healthcare professional before considering using latanoprost for this purpose.
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I do wish Bryan was more transparent about his pace of aging tests. The average of his 3 best scores looks quite impressive, but I’d be curious what the full distribution looks like.
Anecdotally, my pace of aging worsened despite many biomarkers improving, which is a bit perplexing to me. The TruDiagnostic test is quite opaque, but some of the methylation correlates they reveal were not even close to my measured markers, which makes me a bit skeptical of my results overall.
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