https://www.nature.com/articles/s41586-025-08589-9
The glycocalyx forms a physical and charge barrier on the vascular lumen, and removal of any major component, including glycosaminoglycans, as shown in previous studies, or mucin-domain glycoproteins, as shown in this work, seems to destabilize the glycocalyx layer and increase vascular permeability3
https://x.com/sophmshi/status/1894799592056848705
Further interrogation of these two cell populations revealed that many DEGs induced by AAV-B3GNT3 occurred in the opposite direction to those observed with ageing, suggesting that overexpression of brain endothelial B3GNT3 promotes cellular changes towards a more youthful brain state (Fig. 5g–i and Extended Data Fig. 10e–i). Indeed, aged mice treated with AAV-B3GNT3 exhibited increased expression of genes related to neuronal homeostasis (Rims4, Wnt5a and Foxo3) and neurogenesis (Smad1, Syngap1 and Ccnd2) in neuronal populations and reduced expression of activation- and disease-associated genes in glial cell populations
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