#1

“ Artificial sweetener triggers insulin spike, leading to blood vessel inflammation in mice”

“Aspartame increases insulin levels through parasympathetic activation. An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis”

https://doi.org/10.1016/j.cmet.2025.01.006

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#2

Yes, I know aspartame is not the one to pick. What is the one? Allulose looks good and I use it, also trehalose, though expensive is good. Inulin has upset my stomach one too many times and I’m quitting it for a while.

#3

So aspartame consumption that is associated with the harmful effects in the study is around 12 mg/kg/day which is about 4-6 diet sodas per day for a 70-kg person.

Unless you’re crushing diet cokes all day, I wouldn’t get too worked up about it.

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#4

No diet coke for my pet mouse.

#5

I used to drink that many diet cokes everyday…easily a 6-pack a day (no coffee or tea for my caffeine). That isn’t a lot of soda (that’s like 1 Big Gulp, may my Father rest in peace). I gave up soda in 2009 but had many gallons over the years. If I drank soda I’d worry about it.

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#6

I’m playing with Xylitol for oral microbiome support.

#7

The study is based on poor science and would ignore it.