#83

Well according to Brian Kennedy he advises against taking Rapamycin and AKG together because they both down regulate Mtor and taking both together may down regulate Mtor too much. It does not directly down regulate directly like Rapamycin but through the AMPK pathway if I read correctly

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#84

It would be useful to read up on that if you can provide a link.

#85

I read it quite a while ago on a YouTube video in which he spoke about it. Brian Kennedy has done a lot of research into what happens when several interventions have been applied at the same time. Generally they are not synergistic but occasionally they are. Concerning Rapamycin and AKG being as they are both Mtor inhibitors it is rather obvious that it could down regulate Mtor too much. Brian Kennedy has not researched this but he just mentioned it as a personal guess

#86

This:

Has:

AKG may activate mTOR by replenishing the TCA-intermediate pool.

and

Thus, AKG inhibits ATP synthase, consequently reducing ATP level and oxygen consumption, which leads to indirect mTOR inhibition and autophagy activation.

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#87

This is not the paper I read but the conclusions are the same. Thanks for the informative link

#88

How is this going for you? Mine arrived today.

#89

It’s going well. However, I can’t really feel or see any difference. No good or bad side effects that I can notice.

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#90

Thank you. I will trial it since I have just bought it- no side effects works well for me. I did more reading on it and I think this wont do any harm at least.

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#91

He seems overly pessimistic about combining longevity interventions. I’m personally more optimistic that most things work better in combination. He made vague comments about noticing things in rats about it but never got specific.

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#92

I may be misremembering, but I had thought the ITP found the combinations rarely work. Perhaps we are all being optimistic?

Here is a link of a discussion of this in this forum: Efficient Combination of Longevity Strategies - #2 by Ray1

#93

Rapamycin and Acarbose together certainly worked better than when each was used alone

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#94

Where do you procure Potassium AKG from?
Bulk Supppements sell arginine AKG. I think it costs mich less tha. Rejuvant etc.
Since most of the data is on CaAKG, is it safe to extrpolate therapeutic equivalence to arginine or Potassium AKG?
Been taking for 2 months. Haven’t noticed any difference in performance. I felt pretty good prior and after taking it. I do Zone 2 cardio 3-4 days and zone 5 interval training 2 days a week.
Resting heart is 50-53.
HRV 70s

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#95

Sorry, that was an error on my part. I was taking Nutricost Arginine AKG and Nutricost Potassium BHB. I noticed no subjective benefits from them except the Nutricost Arginine AKG, which lowered my blood pressure a little bit.

#96

I once spoke to a researcher who specializes in muscle growth. He maintained that oral Arginine is not well absorbed.

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#97

I think that the CA-AKG formulation is designed to counteract the acidity of AKG, at least as recounted by Bryian Kennedy (and hoping my memory serves me well enough). It would seem that (as recounted also by Andrea Meier of Singapore University) the main longevity benefits due to Ca-AKG is actually healthspan benefits related to counteracting frailty, and this would agree with the slight anabolic effect of AAKG observed by bodybuilders, an effect which probably targets musculoskeletal tissue, including tendons and connective tissue.
AAKG is also part of a formulation of supplements prescribed by orthopedists here for tendon issues.
I did not notice positive effects from the assumption of AAKG, but to tell the truth, I never observed any direct impact from any other supplements, barred berberine, which was anorexizant at the dose of 1000 mg/d.

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#98

I just randomly decided to start taking AKG again, but the A-AKG version which is cheaper. I got excited about it from the 7 years younger biological age news, but stopped after the ITP result. Brian Kennedy still seems to like it, for what it’s worth.

AKG appears to decline as we age, so I like the idea of that not happening. It’s cheap (except if you take the C-AKG version). I hope this continues to be researched.

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#99

I have a question!!!

I don’t know anything about akg other than it’s thrown around as a potentially good thing.

A few months ago I started taking calcium for my low levels of osteoporosis.

Google says CA-AKG can help too.

If one should be taking calcium, is there any reason to take regular ol’ calcium over ca-akg?

If not, is there any downside of switching to ca-akg for the potential benefit of akg

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#100

I’d defer to the physicians for specific advice, but while Ca-AKG does appear to have some benefit in reducing osteoporosis, I’d point out that as a calcium salt attched to AKG its probably not enough calcium in a normal supplement to satisfy your daily needs for calcium. I think I started this thread long ago because of a clinical trial that showed some longevity benefits, but it is now being touted for a variety of benefits, including preventing arthritis. One caution on your calcium intake: there have been some studies that have raised concerns about taking too much calcium in one dose because it could potentially lead to calcium deposits in arteries, causing heart disease. So it may be best to take 500 mg or less at a time.

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#102

It makes more sense to take AAKG anyways. There’s evidence that high dietary calcium (700-1,000mg/day) or calcium supplementation (1,000mg/day) increases CVD and CHD risk in certain subgroups.

The mice in the ITP are taking the human equivalent dose of 3.75g supplemental calcium. I’d like to see it repeated with AAKG.

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#103

Yea I would much rather avoid taking extra calcium, however, the version of AKG tested that reversed biological aging according to those (questionable) aging clocks was bound to calcium, so that’s why I used to use that version. Nutricost A-AKG is really cheap though. $20 usd for 120 days worth of it if you use 1g per day. I figure it’s low risk and either no reward or high reward.

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