Hi Karl. For what you say, I see that there are some parts of the story that maybe you don’t know, so I will tell you about it. The “substance” was a secret for 3 and half years, until October 2023, when Katcher published an article in the journal Geroscience describing the whole isolation process, so then we learnt that the “substance” was extracellular particles containing small extracellular vesicles from young pigs plasma. Also, when that article was published in 2023, Steve Horvath had already updated his epigenetic age clocks, so the rejuvenation wasn’t of 54% anymore, but of 67%. You say that the company started, and then “it all just falls trough the cracks”. An important fact is that according to Google Patents, the patent wasn’t granted yet. Also, Katcher is 81 years old. So, what happened with the company is plausible. However, I agree that the whole story is odd. At the same time, there are many elements in the story that indicates that it’s possible that those extracellular particles really rejuvenated the rats, including the many scientific articles published by other scientific groups in recent years showing that small extracellular vesicles (even from other species) could rejuvenate mammals. So, it’s precisely the ambiguity of this research that led my wife and I to start this initiative of reproducing the experiment, in a non-profit environment, with total transparency of materials, methods and results, without seeking any intelectual property. We want to know if it’s true, you see? I’m in doubt about the original experiment of Katcher since I read his article for the first time more than 5 years ago. And I’m still in doubt. Our experiment exists precisely because of this doubt.
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Hi Hamtaro. The doubts about Sima experiment are well explained in your post. So, as I just explained to Karl, those doubts are an example of what drives my wife and I to reproduce Katcher’s seminal experiment. I see many people in the rejuvenation field that either think that Katcher’s experiment results are real or think they are not real. I don’t think that those are the only two alternatives. In my case, I’m in doubt, because at the same time that there are strange elements in the story, there are many indications that it’s true. So, I can’t simply continue with this doubt, since if the experiment was valid, the whole world could change. This needs to be clarified as soon as possible.
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@nico_cher You and your wife are doing a courageous scientific experiment. I am interested in seeing your results, and I am sure many people here are too. I wish you all the best and I hope you can beat Sima’s record!
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