Any experiences with Indolepropionamide?

[Walter_Brown]

Thank you! Found this too , but unsure of quality https://everychem.com/product/indolepropionamide-solution-6mg-ml/

[Sigma]

Yes correct. I have not ordered from them before, but my understanding is they are also a reliable source.

[Walter_Brown]

Here is the link to “Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer’s disease”: https://www.sciencedirect.com/science/article/pii/S0969996121001522

[Sigma]

Nice, from what I’ve read it’s a very promising longevity molecule. I have no idea why it has not been discussed here before. I will be testing it soon.

[Walter_Brown]

My only concern is negative impacts that research might uncover in a few years. But that’s always a risk…

[DaltoAlessandro]

I’m also experimenting with IPAM sourced from pglchem, but I’m having contradictory effects.
Can we talk in private?

[DaltoAlessandro]

The problem with that is the solution, tween-80, peg-400, propylene glycol are not good for longevity.

[AustraliaLongevity]

Woahhh. Gonna need to read up on this one a bit more! I’d love to see some data on C Elegans and other species.
https://genomics.senescence.info/drugs/drug_details.php?compound_name=Indolepropionamide

[John_Hemming]

Its actions on complex 1 are key in reducing the rate of mtDNA damage. I wonder if mk7 has similar effects. We don’t know, however, what side effects this has. It could be very significant.

[AustraliaLongevity]

I just looked it up on Reddit and there are a bunch of people talking about taking it on a nootropics subreddit.

Strange that something so potent isn’t being studied more.

[AustraliaLongevity]

What was your experience?

[Lost]

All the info here seems to come from the same paper. Are there any other sources?

[John_Hemming]

I don’t think there is much research on this.

One paper referred to had it correcting the effect of toxins. It still needs a good look at because anything that is working around complex 1 is at the centre of the aging process.

[AustraliaLongevity]

I’m talking to Ora Biomedical about getting Indolepropionamide to run a C Elegans lifespan study.

[John_Hemming]

That would be interesting. The worm studies have lots of issues, but they are a relatively cheap data point. A mouse lifespan study would be really quite helpful.

[AustraliaLongevity]

Worms are a good starting point, then move up to slightly larger species until we get to mice. Getting all of that data in between could get other researchers and groups eager to run the study. BTW I just made an in depth post on Indolepropionamide if you are interested.

[John_Hemming]

Where is the “in depth post”?

To me the question is whether Indolepropionamide has material effects in normal circumstances or only when complex 1 is compromised. It is also not clear how it compares to the longer chain menaquinones.

Obviously some people are taking it and it is endogenous to rats so probably more generally endogenous although it has a different pathway from tryptophan to that of melatonin.

[AustraliaLongevity]

268% Median Lifespan Increase with Indolepropionamide aka Indole-3-propionamide or IPAM – What this is, and why more studies NEED to be funded!

What is Indolepropionamide? IPAM is a tryptophan-derived indole that chemists describe as a “reverse melatonin.” The core indole ring is identical to melatonin’s, but instead of a 2-carbon N-acetyl side chain and a 5-methoxy group, IPAM carries a 3-carbon propionamide and no methoxy. This gives it two key properties: High lipid permeability, so it crosses cell membranes and the blood–brain barrier with ease. Markedly longer tissue persistence (~6 h in rat brain versus <1 h for melatonin). Main Mechanism: IPAM lodges at mitochondrial Complex I, streamlines electron flow and prevents “leakage” that ordinarily forms superoxide and downstream reactive oxygen species (ROS). Because it can cycle between redox states without turning into a pro-oxidant, one IPAM molecule can neutralise many radicals—hence the label catalytic antioxidant. It very likely does more we are not aware of. What The Studies Say: The only lifespan study published so far (rotifers, 2010) reported a stagge…

@John_Hemming

To me the question is whether Indolepropionamide has material effects in normal circumstances or only when complex 1 is compromised. It is also not clear how it compares to the longer chain menaquinones.

The question is how it changes lifespan. We can figure out the minutia later.

[John_Hemming]

@AustraliaLongevity

The question is how it changes lifespan. We can figure out the minutia later.

Thanks for putting a link in to the post. The reason I focus on complex 1 is that it is the ROS from complex 1 that cause most of the changes to mtDNA that result in aging. In the body when cells need to not age (oocyte, stem cells) complex 1 is inhibited and the cells take in exogenous pyruvate to maintain the NAD+ levels.

[AustraliaLongevity]

Check out the post and please comment your thoughts I’d love to hear them.