#1

https://www.nature.com/articles/s41392-025-02145-7

In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. However, the current symptomatic and disease-modifying therapies have achieved limited benefits for neurodegenerative diseases in clinical settings. Halting the progress of neurodegeneration and cognitive decline or even improving impaired cognition and function are the clinically meaningful goals of treatments for neurodegenerative diseases. Ageing is the primary risk factor for neurodegenerative diseases and their associated comorbidities, such as vascular pathologies, in elderly individuals. Thus, we aim to elucidate the role of ageing in neurodegenerative diseases from the perspective of a complex system, in which the brain is the core and peripheral organs and tissues form a holistic network to support brain functions. During ageing, the progressive deterioration of the structure and function of the entire body hampers its active and adaptive responses to various stimuli, thereby rendering individuals more vulnerable to neurodegenerative diseases. Consequently, we propose that the prevention and treatment of neurodegenerative diseases should be grounded in holistic antiageing and rejuvenation means complemented by interventions targeting disease-specific pathogenic events. This integrated approach is a promising strategy to effectively prevent, pause or slow down the progression of neurodegenerative diseases.

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#2

I’d love to hear what your personal top methods are to help prevent these diseases for you?

I assume high dose melatonin is one of those, rapamycin, but I don’t think I know what else you prioritize?

And that might be the longest article I’ve seen. It will take my ADD brain quite a while to get through all of it!!

#3

What I do myself is quite complicated and varies from day to day. What I am working on is the principles I talk about in this forum which relates to balanced nutrition, targeting high cytosolic acetyl-CoA using various tools and protecting mitochondrial DNA as well as doing some exercise (not very much other than walking at the moment).

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#4

@John_Hemming How well is your protocol working? I recall you measure hair color. Any other measures that are improving as a result?

I can’t claim to be getting younger despite my efforts. I do have some recovery of function related to immune system and cognitive function, so I’m happy. No more illness or allergies. No digestion issues any longer. No more brain fog.

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#5

Its hard to quantify these things. At the moment I am experimenting a lot by taking large doses of various things and seeing what the results are (today is mk7). That does not necessarily correlate with getting good outcomes, but I am happy with the outcomes.

Hair is a struggle. I am making very gradual progress, but it is really gradual although I can correlate it with other inputs.

I think from a cognitive perspective all is good. I switched off resistance training at the end of December and am as a consequence I think slightly weaker. That is not surprising and I intend switching it on again soon. I also switched off PEMF and RIR. I have had a sniffly nose quite often, but nothing more than that. Whether PEMF and RIR affect that or not I don’t know.

In the end my priority is to understand the science behind all of this. I am pretty certain I am making good progress there.

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#6

That’s the truth. The biological age tests don’t work so it’s functional tests and blood markers. I think blood markers are for finding problems. Optimizing blood markers when the tests are not precise just leads to chasing my tail. Functional tests are the thing in my opinion (for now).

Results (status vs yourself at 40)
Energy level (mental & physical)
Mobility (range of motion without pain, walking speed
Strength (hang time, squat/leg press, bench press, military press)
Endurance (length of submax exercise)
Digestion (regular good poops; food sensitivities)
Inflammation (aches, soreness, recovery time)
Immune system (allergies, illness frequency)
Visceral fat level
Hair quality (color and volume)
Sex drive
Sleep (duration and quality)
Oral health (NO, cavities, gum disease)

What else?

I’m better now than I was at 40 except for a few categories which I’m still chasing.

#7

I would tend to agree on this although I don’t have valid measurements to rely on.

In fact in some ways I am better than I was at 35.

I am 65 on Sunday.

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#8

@John_Hemming Well done, and happy birthday!