It really helps you to calibrate the media when you have insights in a particular article or area of expertise that is (attempting) to cover said area!

Some of its purposeful bias, some of its institutional bias, some is just sloppiness and some is unintentional bias.

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image

New poster…

Kudos to you @rberger for doing the interview!

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amuser, this is so, so, so painfully true! I discuss this phenomenon quite frequently with my wife - I didn’t know it had a name, lol! Although unlike Crichton, I would extend it to other parts of life. For example, we tend to take what a professional says at face value, when we are not professionals of that area ourselves - we put undue amount of trust into them. So, my area is the entertainment business - and when I read something said by some entertainment business figure, I tend to look at it quite critically, because I can see how it misses all sorts of nuances if it’s not actually entirely wrong. But I don’t have the same degree of distrust of lawyers, since I am not a lawyer. Yet the reality is, that in every field, whether medicine, law, engineering or whatnot, the highly competent are very few, and the majority are mediocre with a good number being outright bad. So if you come across the “average” doctor, you should trust them as much or as little as you would a professional in YOUR area of expertise. Most people are average - average doctors, average lawyers, average researchers etc. - and that can be problematic to say the least.

This also pertains to journalists. Most journalists are going to be “average” - how likely is it, that the average journalist reporting on an area they have little knowledge of, will get things substantially right, especially if the subject matter is abstruse, difficult or controversial? Odds are that they will not do a 100% accurate job. They’re just your average “X”, whatever the X is, journalist, lawyer, doctor, mtorc1 researcher.

People think that scientists are somehow immune to this “average” rule - hardly. We on this board who attempt to read up on and examine countless medical studies are after all acutely aware of how problematic vast numbers of studies are - and that is not even mentioning the actively malign, like the epic amounts of fraud in so many papers.

Relying on others for your research is always a fraught affair. It is a hard reality, that we have no choice but to operate on a level of trust, experience, heuristic rules of thumb, principles and general rules when making decisions about many areas of life. We can’t be specialists in each and every facet of life - medical, legal, financial, car mechanic, airline pilot and candy maker. We have no choice but to rely on the expertise of others. Which is why we have to prioritise where we put our energies in. I am willing to trust the mechanic without taking the car apart for myself, I pick the mechanic based on recommendations and personal experience of the person, watching, etc. - I am not a car specialist. But in some areas, sorry, but I do have to take a deep dive and can’t just “take their word for it” - it’s my very life/health… I can always get another car, I can’t get another body. I also take charge of my finances and have no use for a “financial advisor” - money is too important in life to let someone else make financial decisions for you, I decided that I have no choice but to take a deep dive into that area if I don’t want to end up living under a bridge.

The Renaissance was the last time a well-educated person could be on top of all current knowledge that the civilization offered, a la Leonardo da Vinci. Today, you’re lucky if you are competent in one narrow area - the rest is luck, intuition, trust and hope.

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To be honest… in hindsight… so glad I didn’t get interviewed by Dana and featured. I would expect about a fifty - fifty positive/negative response, but it’s nowhere even close to that.

Reading the comments… a no win situation… even if they highlighted my positive benefits over the past 4 years. The paper wouldn’t show my medical tests… so I would be written off as delusional.

Then shared all over the internet. Jesus!!

Yep. Dodged that bullet. Thanks for being the rapa sacrificial lamb.

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I tried, but it was rejected…maybe because I used the link you posted to the “unlocked” article. I was able to post the normal link to the article on r/Rapamycin on Reddit.

https://www.reddit.com/r/Rapamycin/comments/1forbge/new_york_times_article_on_rapamycin/

Really…you got banned!! You’re my hero! That’s what I keep trying to do here… but I haven’t figured it out yet…@SNK/kansel/mogli has been coaching me…and I’m watching @AnUser closely…but obviously there’s an art to it…be patient, grasshopper.

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https://danagsmith.com/about

Previously, I worked as a senior staff writer at Elemental, Medium’s health publication. I debunked weird wellness fads in my column, Optimize Me, and provided the scientific rationale for sensible health advice, like why exercise is so darn good for your brain.

Sample article title below.

Optimize Me is an Elemental column exploring (and fact-checking) the weirdest self-improvement trends. It comes out every Tuesday.

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“not good ideas”

What!!! I thought saying “butt” and “backdoor” in the same sentence would get you banned…

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Based skeptic debooooonker. Unironically. :sunglasses:

I’m… cured… In the rapa dungeon you’ll learn all about it.

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Another Common drug (Metformin) reverses aging in monkeys in potential longevity discovery

Common drug reverses aging in monkeys in potential longevity discovery (msn.com)

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But…but…your avatar is SMOKING :grimacing: :confounded: :face_with_symbols_over_mouth: :japanese_ogre:

Maybe a good thing my 45 minute discussion with a lot of detail and science with Dana didn’t get put out there. What a complete cluster - totally the opposite of what was expected. Yes Agetron - dodged a bullet … and my initial annoyance of having prepared carefully for the interview, having her questions in advance … and not even a mention of anything conveyed. It’s disrespectful and rude. Don’t come and take up someone’s time when you aren’t going to use the content - when it is quality content. Anyway - think I dodged a bullet … but the quality of the end product isn’t what it could have been.

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Welcome!
See previous discussion here as well:

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I took rapamycin for several years at a low dose (2 mg a week) for anti-aging purposes and experienced serious infections that caused permanent damage. In my experience, the potential side effects are often downplayed. I would encourage others to carefully consider the risks before taking this medication.

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Can you please share more details… what other things you were taking at the time, and more details on the exact nature of these infections, and how you measured and identified any permanent damage?

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I began taking Rapamycin about five and a half years ago at a dose of 2 mg once a week, along with metformin and MitoQ (a more advanced form of fisetin). After roughly a year, I increased the dose to 6 mg once a week. Shortly afterward, I developed a severe upper respiratory infection, something I had never experienced before. Fortunately, it resolved without causing permanent damage, and I returned to the 2 mg dose.

Later, while still on Rapamycin, I contracted herpes and experienced an unusually severe outbreak. From what I’ve learned, the intensity of the initial outbreak often dictates the severity of future recurrences, and since then, I have faced frequent, relentless outbreaks. I believe this is due to the immunosuppressive effects of Rapamycin.

A few years later, I intermittently combined dasatinib and quercetin with my 2 mg weekly dose of Rapamycin. Unfortunately, I ended up needing urgent care at the hospital due to a serious infection that caused some necrosis. After discussions with specialists, we concluded that the immunosuppressive effects of these medications were likely responsible. This outcome was unexpected, particularly for someone middle-aged and otherwise healthy.

Based on my experience, I believe there needs to be greater awareness of the potential risks associated with these medications, especially Rapamycin and metformin. For me, these treatments did more harm than good.

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Well, our goal here at the site is to identify all the benefits as well as the downsides to any new potential longevity therapeutic, so I appreciate you sharing this information in the detail you have. I encourage everyone who visits here to do the same.

Perhaps some medical professionals here can jump in and ask relevant questions that might help us understand the likelihood that rapamycin contributed towards the risk of getting these bacterial or viral infections, and their severity. We’ve had other reports here of similar issues: Too many bacterial infections, have to stop, low WBC

While I think its a small minority of users, I do think its a risk and its important for us to figure out ways to measure, mitigate / obviate and counteract (if possible) these risks.

When you got these infections did you typically stop rapamycin or continue taking it?

Did you get any blood tests done before or after the infections, that might reveal any issues; for example were white blood cell counts too low? I remember Dudley Lamming suggesting to us that a good way to track and measure our immune system strength may be via tracking TREGs, but I’ve yet to find an inexpensive way to get this tested.

TREGs (T-cell Regulatory Test) (Test details ), Labcorp TREGs test
Test TREGS on the same day you test Trough Sirolimus levels to see if there is significant disruption to your immune system.

I definitely do think that there are risks with rapamycin (though low) and I think it would be great if, as a group, we can work towards identifying factors that increase or decrease these risks. I’m sure, for example, that infection risks for medical professionals who regularly see sick patients and work in hospital environments, may be at a higher risk than a software engineer who works at home alone most of the time; simply due to exposure risks to potential infection agents.

I saw this post on X / twitter recently and it also surprised me - so I do agree that there are issues that we are still discovering with rapamycin. While we don’t hear of these reports often, its important for us to try to learn about the issues, identify the frequency, and identify ways to lower the risks.

Source: x.com

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I really encourage people to do blood tests. In my case I was surprised to see that the half life of rapamycin was 82.5h. That might look not too far from the 62h generally cited but because it’s an exponential clearance it means that the rapamicyn is going to accumulate if I take it every week.

I was also taking 6mg per week but, to avoid that accumulation issue, I now take 12mg every other week instead.

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I was surprised by this comment. Did it have any follow up please (I´d check ti myself but Twitter is down on my country)?

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Thank you Matterhorn, you bring valuable feedback. Anyone thinking of starting on rapa needs to be aware of possible risks, and some can be very severe. My takeaway is that if I find myself having persistent infections, or more serious infections, I have to re-evaluate the wisdom of staying on rapa. I’m not going to try to “tough it out”. The other big takeaway, is that polypharmacy is a seriously complicating factor. When I go on rapa (probably this November), I intend to stop various supps, like turmeric/curcumin, and take rapa away from most other meds on that day, and to add others only after 2-3 days (like carotenoids lutein, zeaxanthin, astaxanthin). We have very little data on interactions, and we all have unique health profiles and drug reactions. Caution is advised, and thank you again for your feedback.

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