Alex,
Incidentally - I checked out your mention of the “Thin Slim breads” - which I had never heard of. Interesting:
Not sure where you live - but the Costco in San Francisco has keto bread for about 30% the price of Thin Slim bread.
URL me the keto bread info?
Jardiance (Empagliflozin) - 25mg (10 Tablets) X 7 = 166.74
I ate one can of pinto beans after that scary increase, it changed nothing
Later today I ate more strawberries and there was a brief increase that quickly went back down.
This is the Keto Bread they sell in the San Francisco Costco:
COSTCO ITEM NUMBER AND PRICE
Artisan Bakers Sonoma County Multi Seed Keto Bread (2) 18oz Loaves is Costco Item Number 1445207 and Costs $8.99 or $4.50 per loaf of keto bread.
Can’t find it in the costco near boston 
I think diet is a weak lever to pull honestly. Imo if your VO2 max is less than 60, exercise is where you should focus your attention from a lifestyle perspective.
FWIW after 60 mins at 80% FTP I can eat WHATEVER I want without spiking blood glucose for about 4 hours.
And, if I have a cold shower after food, then it also totally blunts the BG response.
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JUST STRAWBERRIES DID THIS
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No Cana or Aca before eating the strawberries?
Cana late last night. Acarbose wouldn’t work on them?
Ah - yes, I guess Acarbose would probably have minimal impact on the strawberry BG rise.
Cana lasts about 12 hours I think - so probably not going to help you with the morning meals.
Just ate 20mg rapamycin + 1 grapefruit (I might do this once every 3 weeks). Also ate more keto cookies + bread earlier today. will check BP in 10 hrs
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shc
#132
So that’s equivalent to around what would have been 60mg rapamycin otherwise? 
This after just thinslim breads??
If you’re having such responses to small or minimal amounts of sugar, have you considered that your post-prandial insulin is low? Rapamycin will drive it lower. Insulin supports many functions and should be treated. Consider a 4 hour glucose tolerance.
Furthermore, if this is the case which I highly suspect, you must not drive fatty acids > ketones higher with agents that lower insulin specifically SGLT2 combined with rapamycin. In which case short-acting insulin or long-acting GLP-1 combined with metformin, rapamycin and acarbose.
First consider initiating GLP-1, monitor BG and ketones, build polypill from there. Not medical advice consider working with a doctor.
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That’s possible. Does rapamycin decrease insulin?
ALL THESE ELEVATIONS are just from thin slim breads, higher than usual too… am too scared to test anything higher carb than that for now
Davin8r
#136
If he takes it every day at about the same time, after 4 or 5 half-lives (in the case of canagliflozin, just 2-3 days with a 12 hour half life) he’ll have reached steady state drug levels and the drug is active 24/7. It’s kind of counter-intuitive, but here’s a really good discussion (I had to brush up on it myself since I haven’t studied pharmacokinetics for a while):
[Understanding Repeat Dosing & Steady-State Concentration]
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shc
#137
So how’s the 60mg equivalent dose going. Any interesting observations?
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It’s variable on the degree of which, but yes this is called “benevolent glucose intolerance.” Based on your responses, I agree, it’s probable cause. Regardless of cause, I’m almost certain you are low in post-prandial insulin. As I mentioned the solution is not to drive blood sugar down with canagliflozin or SGLT2, as there’s a high chance it will lead to undesired outcomes; could be quite dangerous in fact.
Measure 4 hour and monitor ketones.
Davin8r
#139
I don’t see how this would be dangerous. It’s what many of us are doing, including Peter Attia. SGLT2 inhibitors help dispose of excess glucose into the urine but don’t really “drive glucose down”, per se. And rapamycin doesn’t decrease insulin secretion to the point of being like a type 1 diabetic who can’t secrete it at all. I could only see it being theoretically dangerous if rapa+SGLT2i combined with a ketogenic diet (but then, why even take an SGLT2 inhibitor if no carb intake on keto diet?).
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Davin8r
#140
BTW I’m on my second CGM (Libre 2) and no longer have any confidence in the accuracy of these things. I l have 2 finger-stick glucose monitors which are both in agreement with one another (and apparently are much more strictly regulated by FDA for accuracy compared to the CGMs).
The CGMs way overestimate my blood glucose. By 20 or 30 points. I just took a reading from each. CGM says I’m 125, finger stick meter says 86. This is a regular occurrence when I check both. It’s not always this large of a difference, but 20 points is the norm, especially after meals. Fasted, it’s more often a 10 or 15 point difference.
Alex, do you have a standard glucometer? If not, I’d recommend purchasing one and comparing results with the CGM. It’s unfortunate that the Dexcom CGMs are so expensive because at least they allow you to calibrate with finger stick glucometer.
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Yes - that is my experience also, so I just use the CGM as a general trend monitor. The finger prick tests are the real thing - so I usually use both (on a daily or every few days) to get a true reading on my blood sugar levels.
I think in this case the Libre 2 is not as good as the Dexcom CGM which does more auto-correction and where you can (I believe) enter the read data from the finger pricks to help get it more accurate.
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