Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?

John_Hemming · 2024-01-07T07:48:28.273Z

I think this is an acetyl-CoA issue.

MDPI

Age-Related Alternative Splicing: Driver or Passenger in the Aging Process?

Alternative splicing changes are closely linked to aging, though it remains unclear if they are drivers or effects. As organisms age, splicing patterns change, varying gene isoform levels and functions. These changes may contribute to aging...

eg:

PubMed

Histone marks regulate the epithelial-to-mesenchymal transition via...

Histone modifications impact final splicing decisions. However, there is little evidence of the driving role of these marks in inducing cell-specific splicing changes. Using CRISPR epigenome editing tools, we show in an epithelial-to-mesenchymal cell...

Whilst we are at it:

aging-us.com

Single-cell transcriptomic analysis uncovers diverse and dynamic senescent...

Aging | doi:10.18632/aging.204666. Noah Wechter, Martina Rossi, Carlos Anerillas, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Supriyo De, Krystyna Mazan-Mamczarz, Myriam Gorospe

PubMed

Human aging is characterized by focused changes in gene expression and...

Aging is a major risk factor for chronic disease in the human population, but there are little human data on gene expression alterations that accompany the process. We examined human peripheral blood leukocyte in-vivo RNA in a large-scale...