Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence

[约瑟夫]

Administration of L-arginine plus L-citrulline or L-citrulline alone...

Citrulline: from metabolism to therapeutic use - PubMed

[EnrQay]

For those of us with blood glucose control difficulties, this could be a great addition.

And a great word in that second article: splanchnic – of or relating to the viscera.

[EnrQay]

L-citrulline

stimulates protein synthesis in skeletal muscle through the mammalian target of rapamycin signaling pathway

There seem to be many papers on L-citrulline effects on muscular/vascular health including (via elicit.com)

L-citrulline, a precursor of nitric oxide, has been shown to enhance vascular function and muscle protein synthesis, particularly when combined with exercise training in older adults (Figueroa 2020).

Here is the full review article
[Sci-Hub | l-Citrulline Supports Vascular and Muscular Benefits of Exercise Training in Older Adults. Exercise and Sport Sciences Reviews, 48(3), 133–139 | 10.1249/jes.0000000000000223]

[约瑟夫]

My view, take L-citrulline and L-arginine supplementation, eat arugula*{has a high nitrate content] and take tadalafil 2.5mg dissolve under the tongue.{yes I allow to dissolve under the tongue]

Been doing just arugula, will be adding
L-citrulline and L-arginine supplementation

The tadalafil “kick starts” NOS.

Noninvasive assessment of endothelial function can be measured using an EndoPAT device.

*…The European Food Safety Authority (EFSA) has declared that arugula is an essential source of nitrate, with the highest nitrate concentration up to 6400 ppm"…
From:
https://doi.org/10.1016/j.meatsci.2022.109090

The Effects of Oral l-Arginine and l-Citrulline Supplementation on Blood Pressure

[EverVital]

Be sure to avoid hypotension (low blood pressure) since both L-citrulline and tadalafil reduce blood pressure. I haven’t found any studies specifically evaluating the combined risk, but I’m also not sure why it’s necessary to take such an aggressive BP lowering stance if one is not hypertensive.

Same goes with combining L-citrulline with other BP lowering meds, approach with caution.

[DeStrider]

This is why a lower blood pressure is important.

我们应该达到的最佳血压目标是什么？收缩压低于 110 或 100？

‘Normal’ blood pressure is no longer a safe haven: take shelter under ‘optimal’ blood pressure Several population-based studies have demonstrated that SBP levels currently considered normal (<130 mmHg) are not safe, and in fact, there is a graded increase in CVD risk as SBP increases beyond 90 mmHg.4–7 Whelton et al .6 found that the amount of coronary artery calcium and the risk of incident atherosclerotic CVD increase with increasing SBP levels, even in individuals with SBP 90–120 mmHg. In fact, mounting evidence has made it abundantly clear that so-called high normal BP levels (120–129 mmHg) are associated with a significant increase in incident CVD compared with SBP levels of 90–100 mmHg. This connection may be much more pronounced in yet to be identified subgroups. This means that CVD risk starts even when SBP is a long way below 130/80 mmHg, which is the current threshold used to diagnose and define hypertension.8 Therefore, the guideline-based definition of normal BP does not …

[EverVital]

We’re talking about hypotension with clear negative symptoms, such as dizziness and even fainting. This can be an issue for the elderly especially.

I applaud self-experimenters that weigh the benefits and risks, and take a measured approach to their trials. Seeing proposals that combine substances with potentially dangerous negative synergistic effects is concerning and should at least come with a warning (which is all I’m trying to do).