#24

I’d say lithium orotate is better and it works quite well with Rapamycin.

2 Likes
#25

Lithium orotate (very low dose) is what most of us here take, I think. Its easily available on amazon.

1 Like
#26

aspartate as well. (extend to 20 chars)

#27

What dose is that?

o

#28

The low dose is either 1 mg or 5 mg. I prefer 5 mg.

If you take an SGLT2I it will reduce the dose by about 50%.

I take an SGLT2I.

1 Like
#29

I take 1mg, and for more on the rationale for these low doses I recommend you read up here: Lithium Supplementation

3 Likes
#30

Do you have a type / brand you prefer?

#31

I like DoubleWood for lithium orotate.

1 Like
#32

I use https://www.amazon.com/dp/B07TWQB8LG

but no great affinity towards it… it seems ok. there are no reviews of lithium supplements (I have seen) so its hard to know their quality.

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#33

My personal calculations were that 5mg was just about on the high side and I dropped back to around 2mg. (this is of elemental lithium which is probably what they have). I am not sure there is a material difference between orotate and aspartate as it is elemental lithium that does the biz.

I use the Life Extension brand, but primarily because I wanted a daily does less than 5mg.

3 Likes
#34

To be clear, SGLT2 drugs reduce absorption of lithium by 50% and not the other way around? Also, is this for bipolar doses?

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#35

Based on my understanding, SGLT2I take 50% of the glucose, some of the sodium, and about 50% of the lithium (and other minerals for which I don’t have values) and dumps them into the urine. SGLT2I will reduce the effectiveness of other supplements due to their mechanism of action.

3 Likes
#36

I need to read more about this. I wonder if timing supplements away from an SGLT2 would help.

3 Likes
#38

Please share anything you find out regarding SGLT2 and other supplements. I’m curious as well!

2 Likes
#39

From the case study, it appears empagliflozin reduces lithium blood concentration by 70% instead of 50%. See second link.

Inhibition of SGLT2 likely leads to **increased urinary excretion of lithium and decreased serum lithium concentration, which potentially reduce lithium’s therapeutic effectiveness.**4,10,13 While existing theoretical models suggest minimal involvement of SGLTs, a recent literature case report describing positive dechallenge and rechallenge with empaglifozin-induced reduction in serum lithium concentrations suggests a more substantial role of SGLT2 in lithium reabsorption.4,8

Link:

5 Likes
#40

hi, do you know if Bryan Johnson is still on one MG a day of lithium

#41

blueprint Yes, looks like it

#42

I don’t see anyone previously posted this - but I really found this OptiSpan podcast excellent on the subject of Lithium (and Rapamycin). Very interesting stuff!

10 Likes
#43

i thought so too. Particularly their speculations on the mechanisms involved. Do you know the test they refer to? (from memory it was for tau and amyloid fragment to amyloid ratio).
Interested to see if it accessible on the UK

1 Like
#44

Yes I do … it is here. Physician ordered and discounted through UltaLabs is $949

4 Likes