A primer on Lithium, Lithium + Rapamycin, etc. potentially more stable and safer pharmacokinetics

DrFraser · 2024-10-19T13:07:42.744Z

I don’t see anyone previously posted this - but I really found this OptiSpan podcast excellent on the subject of Lithium (and Rapamycin). Very interesting stuff!

L_H · 2024-10-20T07:39:17.662Z

i thought so too. Particularly their speculations on the mechanisms involved. Do you know the test they refer to? (from memory it was for tau and amyloid fragment to amyloid ratio).
Interested to see if it accessible on the UK

DrFraser · 2024-10-20T09:57:52.568Z

Yes I do … it is here. Physician ordered and discounted through UltaLabs is $949

Labcorp

Labcorp's Amyloid-Tau- Neurodegeneration (ATN) Panel

Labcorp is the first company to make a fully blood-based Alzheimer's ATN Profile commercially available - giving physicians a simple test for Alzheimer's disease pathology to help speed up diagnosis.

CronosTempi · 2024-11-03T13:11:16.037Z

Some light on what lithium does:

PubMed Central (PMC)

Lithium and Autophagy

Lithium, a drug used to treat bipolar disorders, has a variety of neuroprotective mechanisms, including autophagy regulation, in various neuropsychiatric conditions. In neurodegenerative diseases, lithium enhances degradation of aggregate-prone ...