#21

I do not care for capers.

Anchovies without capers.

Rapamycin with anchovies!

1 Like
#22

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601579/

#23

Try Kaempferol Powder 50% Extract

#24

Lets track the research on this going forward…

It might be worth a try earlier rather than later if the side effect profile was a little more palatable…

Adverse Effects

Adverse effects listed are all grades of severity unless indicated otherwise

Note *: Adverse reactions are for patients treated with dabrafenib and trametinib

>10%

Monotherapy

  • Increased AST (60%)
  • Rash (57%)
  • Hyperglycemia (50%)
  • Increase ALT (39%)
  • Leukopenia (38%)
  • Anemia (46%)
  • Neutropenia (44%)
  • Diarrhea (43%)
  • Hypoalbuminemia (42%)
  • Hyperphosphatemia (37%)
  • Hyperkeratosis (37%)
  • Headache (32%)
  • Lymphoedema (32%)
  • Pyrexia (28%)
  • Arthralgia (27%)
  • Papilloma (27%)
  • Increased alkaline phosphatase (24%)
  • Alopecia (22%)
  • Palmar-plantar erythrodysesthesia syndrome (20%)
  • Acneiform dermatitis (19%)
  • Stomatitis (15%)
  • Hypertension (15%)
  • Abdominal pain (13%)
  • Hemorrhage (13%)
  • Back pain (12%)
  • Cough (12%)
  • Myalgia (11%)
  • Dry skin (11%)
  • Constipation (11%)

Source: https://reference.medscape.com/drug/mekinist-trametinib-999854#4

1 Like
#25

At what dose?

“Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy.” ~ Paracelsus

“If you wait until you are ready, it is almost certainly too late.” ~ Seth Godin

I am not the waiting type.

#26

It is the combo with dabrafenib that produces adverse reactions.

Note *: Adverse reactions are for patients treated with dabrafenib and trametinib

1 Like
#27

I would need years and massive amounts of information and tests to be interested in this at all.

I liked Juan’s cranberry solution much better. It won’t work, but it won’t make you suffer either.

1 Like
#28

Do you have links to these prices? How did this research study on flies afford the Trametinib?

#29

You would have to ask the researcher where they acquired the supply for the study (if is is not mentioned in the paper)

Anyone taking Trametinib?
#30

I did a search in the India Pharmacy Pharmaceutical Market.

₹ 78,000

At today’s ( 02/18/2023) Exchange Rate cost is $942.42

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#31

They got it from LC labs. It looks like Trametinib is only DMSO soluble, “ is practically insoluble in the pH range of 2 to 8 in aqueous media . MEKINIST (trametinib) tablets are supplied as 0.5-mg, 1-mg, and 2-mg tablets for oral administration. Each 0.5-mg tablet contains 0.5635 mg trametinib dimethyl sulfoxide equivalent to 0.5 mg of trametinib non-solvated parent.”

I assume the tablets wouldn’t be able to be ground up and placed in rodent chow?

#32

Can I ask what are you trying to do?

#33

I’m trying to determine if Trametinib is a drug the NIA ITP could easily test in a mouse study.

What I don’t know is if a tablet bound with DMSO can be ground up and placed into food

#34

No need to worry, the ITP guys can get it from a chemical supplier like Sigma-Aldrich or directly from Novartis. You can submit an application to them if you got time to spare.

https://www.selleckchem.com/products/gsk1120212-jtp-74057.html

2 Likes
#35

If you scroll down to the bottom of the link you provided the powder still needs to be formulated with DMSO to be bioavailable I think. If they formulate with DMSO and then grind it all up into rodent chow does that work? Or does it separate it out from the DMSO? I don’t have enough of a chemistry background to know these things

#36

Nitrogen Bisphosphonates can inhibit ras in the mek pathway

#37

For a laymen what is the bottom line?

#38

(124) What’s delaying regenerative medicine? Bill Faloon at RAADfest 2023. - YouTube

Fast-forwardto 42:00

Sources for Trametinib??

1 Like
Anyone taking Trametinib?