Have you seen this study, a similar effect with AKG
1 Like
medaura
#134
So not to hijack this thread, but I find myself unexpectedly pregnant… a little terrified because of my stack to date. Quitting rapa cold turkey of course but wondering if the hive mind here knows of supplements that can be beneficial during pregnancy. Maybe I can do better than a run of the mill prenatal.
Thoughts?
All my grand interventions are now indefinitely on pause. And yes this was not planned and I’m 37 so rapa surely didn’t hurt fertility in my case.
10 Likes
I would back off on most of the supplements and restart with an orientation towards optimal pregnancy health (vs. longevity). Choline is very important, and frequently overlooked:
3 Likes
medaura
#136
I somehow knew about Choline from way back. Always supplemented with lecithin in my pregnancies. Of course this is what I meant, as I am stopping all my longevity supplements / interventions but wondering what else is good but little known to take during pregnancy? The equivalent of choline that I haven’t heard of?
2 Likes
Any other women experience any rapamycin issues / side effects like this person has? My Rapamycin Symptoms (female)
medaura
#138
I can’t even imagine what it must feel like for my ovaries to be palpable, even the way she describes it. I’ve taken some high dosage in my day, nothing of the sort.
1 Like
Another user report on rapamycin for menopause here:
Here’s where it gets really interesting again! My partner dipped into menopause and then rocketed back out!
See full post here: My DOG, My PARTNER, and ME: A Week by Week Rapalogue - #85 by HigoMe33
2 Likes
I am still touching base with the researcher who has done (is doing) this research (mentioned below) on rapamycin and ovarian function in mice. The paper has not yet been published. Here is his most recent update from today:
Yes, the manuscript is still in preparation after repeated experiments. We are taking some time to replicate experimental conditions to see if the effects we hope to see persist.
Rest assured I will share our work…as much as I would want to when we submit.
Kind Regards,
=====================
This is the information that prompted me to search out the contact info for the researcher, and see if I could get more information:
3 Likes
Okay so the clinical trial dose is 5mg a week for 12 weeks, I assume they are titrating up to that the first week or two. Do we know if they are on birth control until the 12 weeks ends? Is there an amount of time between stopping Rapamycin before becoming pregnant? Does anyone know any further details here??
3 Likes
Did you and your partner decided to start rapamycin for fertility?
1 Like
Neither of us. We were trying but no success - the main reason we were declined for ART was AMH level. was only curious because if increased AMH was due to the improvement of follicle recruitment & growth it’d make sense that the environment (and egg quality) in effect improves or is in some way restored. Since the effect seems to be slowing down eggs being released, that doesn’t imply the improvements that follicle recruitment process optimization would have but I don’t know. Not really personally relevant at this point, that ship has sailed. Just curious. Interest is anti-aging.
4 Likes
Sirt6
#146
A friend of mine (35, Hashimoto’s) wants to freeze her eggs for later pregnancies. After stimulation, she had only 3 follicles, which where large enough for becoming eggs.
Her general reserve is minimal to begin with. Additionally, freezing, unfreezing, fertilizing and implanting causes loss.
Do you have any suggestions?
It’s a friend and I don’t want to suggest anything, that could harm her. On the other hand, my best guess would be one or two of the list: Rapamycin, Metformin, Ca-AKG, Inositol.
2 Likes
Couple suggestions that are mainstream include the supplement plans from “it starts with the egg” 3rd edition and the book suggestions for low amh, age, and autoimmune factors. The supplement plan includes inositol (I assume she is not PCOS if her AFC is 3 after stims)
With hashimotos many women choose to give LDN a shot based on inflammation affecting follicle recruitment (especially if also trying naturally/IUI) and apparent reduced implantation failure. If she isn’t on an anti-inflammatory diet already that’s another reasonable suggestion along with reducing toxin exposure.
There are some fertility clinics that use a “kitchen sink” approach with autoimmune/implantation factors recommend strict keto or carnivore diet. At 35, if it were me, I would to try and reduce inflammation and increase egg quality without getting too far outside of what has been reasonably researched in humans with a low risk of adverse effect.
She is still young so has time to bank eggs - egg quality over quantity. It only takes one quality egg.
2 Likes
Interesting news… I’ve reported in the past that I fed my chickens rapamycin for several years and it seemed to maintain their egg laying ability at youthful levels. Rapamycin is in many ways considered to mimic the effects of caloric restriction… so this would seem to make sense.
Prolonged severe caloric restriction in hens restores their egg-laying capacity, slows aging and increases survival.
3 Likes
Congratulations.
That is awesome. It’s actually what I am hoping for. Would you mind telling us what you were taking?
During pregnancy I would advise adding additional B vitamins, Iron, and Multi mineral (calcium, magnesium and zinc). I took all of those during my last full term successful pregnancy.
Thank you for this information. I was taking it 2-3 mg a day for 2-3 days at the beginning of my cycle. I may have to try that method to see if I get any results. I hadn’t taken it for a few months because I was running out and getting mouth sores.
1 Like
I was just listening to this interview with Longevity researcher Colleen Murphy at Princeton U., and she mentions some research she’s done on mitochondrial health as it relates to egg (oocyte) and fertility health. They’ve found (as have other labs) that the supplement Urolithin A seems to really help with egg quality, by boosting the mitochondrial health in the eggs.
If you’re interested in this topic, I recommend you listen to the podcast - queued up for this specific part of the discussion. Research below on this topic also (below the video):
Research on Urolithin A and oocyte Health
The research that Colleen Murphy’s lab did on this topic:
相关阅读：
Here: Urolithin A (UA) One of 4 Promising Agents 2024 by Brian Kennedy of NSU
Here: More good news on Urolithin-A
4 Likes
