#41

I never looked that much into it but it is read many many many times, you could probably get the individual sequences out of the bam of fastq with the right software

#42

There is a way to do it. It is not one of my key focuses at the moment so I am not trying to get it done. However, I would think it would hit DTC at some stage.

#43

A year ago I wrote a short piece about why I have not yet had my genome sequenced and why I donā€™t think itā€™s worth it for most people at this time. This may be of value to people here to read before jumping on buying whole genome sequencing tests. Here is what I wrote last year on this:

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#44

Thanks @Olafurpall read the piece. I agree with you that we should not fall for hype about how much whole genome sequencing can help us today. But I do wonder if your pieces is a bit too pessimistic for going into mid 2024 and the next few years.

Whatā€™s your thought on this - Whole Genome Sequencing - #5 by Neo - even at this more conservative level it seems worth a few hundred to have oneā€™s whole genome?

#45

The 30x package is not searchable I believe. I got the cheaper package not knowing that I couldnā€™t search for a specific gene. They want me to upgrade, which involves a new sample and paying for the lifetime access again. Iā€™m looking for a third party like promethease to help with my raw data, but I canā€™t find one.

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#46

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https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00187-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379124001873%3Fshowall%3Dtrue

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#47

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https://www.cell.com/med/abstract/S2666-6340(24)00087-4

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#48

too much marketting crapā€¦ upgrade this thisā€¦ i got very put offā€¦ anyway even some of their predictions about my traits are totally wrongā€¦ for me it does not tell me anything. But I didnt get the WGS. I thought all DNA test are the sameā€¦ I mean DNA does not changeā€¦

#49

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https://www.cell.com/ajhg/fulltext/S0002-9297(24)00120-4

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#50

I used 23&Me, uploaded to Promethease. This told me my biggest risks and I was also able to tell that I did not have the risk alleles for several genes that I was concerned about because they are known risks for greater tendency to Alzheimers. I got enough information about the cardiovascular risks and the colon cancer risk to take action. Would be interested in more detail but not sure it would really make that much of a difference. But the two big risks were a revelation so extremely happy that I did Promethease. Might be good to start with Promethease as it is quick and cheap and a very user friendly data base with pointers to research.

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#51

I actually got more confusing answers when I did the whole genome sequencing vs. the SNPs I uploaded the WGS (from nebula) to promethease, and it showed I didnā€™t have the apoe4 gene, SNP said I didā€¦ and it said I didnā€™t have the fox03 (SNP said I did). Also, it said I had a super rare gene that was suppose to kill me off by the time I was in my 40sā€¦ which after exhaustive research, ended up being a nothing-burger.

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#52

Does anyone know how nucleus genomics compares with nebula? nucleus uses 30x (the same im sure) but they say they use american sequencers.

i have some signs nebula genomics is missing some variants b/c it isnt the highest qualityā€¦

#53

Did you talk with the Nucleus group at the Longevity Summit conference when you were there? I did talk to them, and they mentioned they were partnered with Illumina for their gene sequencing: Next-Generation Sequencing (NGS) | Explore the technology

Iā€™m not sure what Nebula uses.

Iā€™m working on a writeup on what Kian presented at the Longevity Summit on their approach and perspective. Will post in the next few weeks.

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#54

So did you figure out if you are APoE4 or not? If so - how? This would frustrate me, personally

#55

For now, Iā€™m just assuming I am APOE4 (the 2/3 variant). But I should discuss this with a geneticist in the near term.