Which supplements do you think are still worth taking?

[Beth]

Thanks for the heads up!

We have a housing crisis here, yet a lot of lumber comes from Canada. This is going to hurt so many people.

[Steve_Combi]

@Beth

a lot of lumber comes from Canada

It keeps our beaver population busy

[relaxedmeatball]

For me:

Magnesium oxide - up to 750 mg, which is where my bowels get loose. This is taken for some supplemental Mg, but actually mainly for gut mobility

Creatine - muscle and brain benefits are pretty well described now

Fish oil - I don’t get enough through diet

Vitamin D3 for 6-8 months of the year

A very boring list. I would almost never do plant extracts, herbs etc because there’s no real way of knowing he purity, effectiveness. I’d rather use pharma products which are better studied and where the product quality is controlled.

[Steve_Combi]

@relaxedmeatball

I’d rather use pharma products which are better studied and where the product quality is controlled

Me too I do take a lot of supps though

[DeStrider]

Talking Docs talk about the Vitamin D3, Omega 3s and exercise study.

How to reverse aging - The Power of Epigenetics, Omega-3, Vitamin D & Activity

[Agetron]

Minimum B-12 might not be enough to maintain DNA health…

When I did my first TruMe methylation test… and had a differential of 13 years biological to my chronological age. Anti-aging specialist Dr. Yelena Budoskaya was fascinated by my results. She warned me to up my B-12… because the rapamycin might negatively affect it. Started daily supplementing B-12.

Been a high normal on blood tests for B-12 ever since… past 4 years.

Link: https://scitechdaily.com/scientists-just-found-a-major-problem-with-vitamin-b12-guidelines-and-your-brain-might-be-at-risk/

Check your B-12 often as a rapamycin off-label user.

[DeStrider]

How much B-12 do you take?

[Agetron]

Past 4-years I have used the Spring Valley Walmart Extra Strength B-12. 3000 mcg gummies. Cost around : $17.50.

I take 2 gummies at bedtime. Blood tests says it all. Last test… off the charts.

My number 1123… top normal 1171. Nailed it.

[AnUser]

FYI: B12 isn’t that precise to actually measure B12 levels in tissues… homocysteine and metylmalonic acid (MMA) is required to know true B12 status, and it’s possible to be deficient with normal serum B12.

What are your homocysteine levels? What have you done to reduce it? Why isn't it part of PhenoAge or aging.ai clocks?

MMA and HC can diagnose B12 deficiency despite normal B12 levels: There are two enzymatic reactions that are dependent on vitamin B-12. Vitamin B-12 is required for methylmalonic acid (MMA) to be converted to succinyl-CoA, and in combination with folic acid, for homocysteine (HC) to be converted to methionine [9]. Therefore, MMA is clearly more specific to vitamin B-12 deficiency compared to HC. A deficiency of vitamin B-12 at the tissue level can lead to elevation of both MMA and HC [1] even when serum vitamin B-12 concentrations are within the reference values. Elevated MMA and HC levels together have been found to be 99.8% sensitive for diagnosing functional vitamin B-12 deficiency [10], which is defined as elevated MMA and HC levels despite normal vitamin B-12 levels in asymptomatic individuals [11–13]. Therefore, using serum vitamin B-12 testing alone may under-diagnose the deficiency of this vitamin. MMA and HC have been identified as early markers of vitamin B-12 deficiency i…

[Beth]

In this video, he shows the test results for various mag glycinate products.

21 Magnesium Brands Lab Tested | Shocking Results!

The last column shows how much chelated soluble magnesium was in the capsule which is why some are in red, even if the actual mg was present.

Note: out of the red highlighted products, he mentioned Swanson is usually high quality, so this would not change his opinion of the brand.

[Virilius]

@Alex

that the met have no idea of the long term effects.

But they do because of extensive trials during and after the approval.

Lots of money to be made by them and pharma off those magic pills!

Pharma makes its money with new medications, not generics.

[vongehr]

pharma makes money by keeping people sick, so therefore they keep pushing statins regardless its generic or not

[Dr.Bart]

@Alex

Lots of money to be made by them and pharma off those magic pills!

:sigh
Doctors cannot make any money from prescribing medications, it’s literally against the law. Pharma can’t even give us a pen. They are still allowed to bring occasional lunch but all of them are tracked under Sunshine Act - available online. Personally I don’t accept any meals because I rather meal prep healthy food to work and rather not eat their pizza, but my staff loves it.

The Stark Law and the Anti-Kickback Statute (AKS) are two separate but related federal laws that aim to prevent fraud and abuse in the healthcare industry, including issues related to medication prescriptions. The Stark Law specifically prohibits physicians from making referrals to entities with which they have a financial relationship for certain “designated health services,” such as prescription drugs. The AKS, on the other hand, prohibits anyone from offering or receiving “remuneration” (e.g., kickbacks, bribes, rebates) to induce referrals for items or services payable by federal healthcare programs.

Ah but doctors have NO problem bombarding their patients with a great number of pharmaceuticals that the met have no idea of the long term effects. That then have major side effects.

OK, aside from the obviously blanket statements, no doctor in their right mind "bombards’ their patients with pharmaceuticals because it’s a FUCKING LIABILITY. Use some common sense, if those drugs like you claim have major side effects, who do you think is going to be liable for them ? Doctors are much easier to sue than Big Pharma with its Big Lawyers, it’s much easier to settle with your medical liability insurance. Every medication has to have a clear indication and clear benefit to risk ratio.

BTW, if doctors fail to treat in a timely manner, then they can be accused of negligence which can results from medical board disciplinary action or a lawsuit.

Please stop making ignorant accusations, you are clearly poorly informed and are harboring deep resentment from some prior experience which makes you irrational.

[Alex]

I have made my point and will now put you on ignore.

Such name calling is not worth reading.

[Dr.Bart]

@Alex

I have made my point and will now put you on ignore.

I appreciate that very much. Last thing I want to read is some is belligerent diatribe from someone so ignorant about medical industry.

[Virilius]

@Alex

Far too often the initial studies are too optimistic about adverse effects.

Then they get detected later on in post-approval surveys.

Off the top of my head, finasteride, and of course opioids.

Finasteride is actually very safe as proven by various studies done on men on it for hairloss or for BPH. This drug has been thoroughly researched by multiple independent instiitutes across various countries and hundreds of lawsuits have shown that there are no long-term side effects (PFS is NOT real, just ask the FDA) nor does it adversely affect ones health. Quite the opposite actually, as it decreases prostate cancer rates and there is a trend towards a lower acm.

But supplements are such a risk? Not buying it.

Supplements are neither natural nor do they have to go through rigorous trials proving safety and efficacy. People who believe them to be safer than medication are simply irrational.

[Dr.Bart]

@Virilius

But supplements are such a risk? Not buying it.

Supplements are neither natural nor do they have to go through rigorous trials proving safety and efficacy. People who believe them to be safer than medication are simply irrational.

Unfortunately this is the kinds of unbelievable ignorance that we have to deal with every day.
The lack of reasoning skills is absolutely astounding. They literally take supplements based on faith.

[relaxedmeatball]

@Dr.Bart

They literally take supplements based on faith.

Well, to be fair it’s usually based on influencers, salespeople and appeals to “nature/natural/organic” lifestyles!

There’s this weird idea that a lab-made chemical provided in a specific dose formulated to maximise absorption and achieve a certain pharmacokinetic profile is bad. It’s made in a scary laboratory or a factory. It comes with a huge information sheet telling you all about side effects.

On the other hand, a bunch of herb extracts, with plants from god knows where, covered with god knows what pesticides, sitting on the floor of a Chinese factory picking up cockroach shits, then being boiled and dried etc is fine. That’s because it’s natural and the marketing will make vague health claims along with nice pictures of flowers and healthy-looking people.

Really, the fact there is basically no regulatory oversight, no accountability, and constant widespread fraud in the industry makes me very hesitant about any supplements. Look at the image @Beth posted. That’s magnesium, which is a hell of a lot simpler than any sort of herbal extract. And you’ve got dosing which is only 10% of the stated dose (Terranics, ZYY), and some that are 10-20% over dosed.

[Wolf]

Interesting - observed that too in my values and wondered why. Will take B12 at a higher daily dose now. Thank you!

[Agetron]

Yes… Yelena Budovskaya is one of the best at Stanford.

Years of research… she is fascinated by age reversal and anti-aging properties of rapamycin.

Obviously knows her stuff. While everything was looking good in my blood panel … my B-12 tanked. I would not have even looked had she not flagged this a typical side effect… of metformin. Not rapamycin.

I was able to counter the reduced levels with a higher daily dose of B-12… in conjunction with metformin.

We all share and go forward together!