#244

Thanks. My quick check shows that foods with low isoleucine also have low leucine. The only way I could figure out to get sufficient EAA and 30-40g boluses of leucine (trigger mTOR) minus isoleucine was to eat a low BCAA diet and supplement with leucine periodically. Not gonna do it.

2 Likes
#245

(05/01/2023)
SUPPLEMENTS

  • Aspririn 81mg(once or twice per day)
  • Centrum Silver(1 time/day)
  • Zinc 50mg(1/day)
  • Super B-vitamin Complex(1/day)
  • Ginkgo Biloba 120mg(1/day)
  • Hyaluronic Acid(1/2X/day)
  • Spermidine(1/2x/day)
  • Acetyl L Carnitine(2/2x/day)
  • Alpha Lipoic Acid(1/2x/day)
  • Ashwagandha(1/2x/day)
  • Bacopa Monnieri 350mg(1/2x/day)
  • Vit C 500mg(1/2x/day)
  • Vit D3 50mg(1/2x/day)
  • Vit K-2, MK-7 100mcg(1/2x/day)
  • Fisetin (2/2x/day)
  • N-Acetyl Cysteine (NAC)(1/2x/day)
  • Nattokinase Supplement(1/2x/day)
  • Nicotinamide Riboside (NR)(2/2x/day)
  • Qunol Tumeric 1000mg(1/2x/day)
  • Ubiquinol CoQ10 100mg(1/2x/day)
  • Berberine 500mg(1/3x/day)
  • Green Tea Extract, EGCG(2/2x/day)
  • Nature Made Cholest-Off Plus(2/3x/day)
  • Metamucil Psyllium Husk (3 teaspoons/2x/day)
  • Omega-3s 1065mg(2/2x/day)
  • Odorless Garlic 3600mg(2/2x/day)
  • Resveratrol 800mg, Quercetin 250mg, MCT 850mg (1/2x/day)

(11/15/2023)
SUPPLEMENTS

  • Aspririn 81mg(1/2x/day)
  • Centrum Silver(1/1x/day)
  • Zinc 50mg(1/1x/day)
  • Super B-vitamin Complex(1/1x/day)
  • Life Extension Magnesium Caps - 500 MG(1/1x/day)
  • Vit K-2, MK-7 100mcg(1/2x/day)
  • Nattokinase Supplement(1/2x/day)
  • Ubiquinol CoQ10 100mg(1/2x/day)
  • Carlyle Sunflower Lecithin 2400mg (1/2x/day)
  • Kyolic Aged Garlic Extract (1/2x/day)
  • Nordic Naturals Ultimate Omega 3’s – 1280MG(1/2x/day)
  • Nicotinamide Riboside (True Niagen NR)(2/2x/day)
  • Nature Made Cholest-Off Plus(2/2x/day)
  • Metamucil Psyllium Husk (3 tablespoons in 10oz water/1x to 2x/day)
  • Acetyl L-Carnitine 1500mg(2/2x/day)
  • NOW Foods Glycine 1000mg(3/2x/day)

For when I go back to work in Amazon Warehouse:

  • Creatine Monohydrate Capsules, 3500mg (?/?/day)
4 Likes
#246

BUY WHEN POSSIBLE:

  • Piracetam - 2–4 g/day
  • Bacopa Monnieri - 300 to 400 milligrams taken daily for several months
  • Panax Ginseng
  • Ginkgo Biloba - 120–300 mg
  • ONNIT Alpha Brain Premium Nootropic Supplement, 90 Count, for Men & Women - Caffeine-Free Focus Capsules for Concentration, Brain & Memory Support - Brain Booster Cat’s Claw, Bacopa, Oat Straw
  • CDP Choline (Citicoline) Supplement, Pharmaceutical Grade, Manufactured in USA (60 Capsules 300mg)

**** “the ITP has identified nine agents that significantly increase median lifespan — acarbose (Harrison 2014, Strong 2016, Harrison 2019), aspirin (Strong 2008), canagliflozin (Miller 2020), captopril (Strong, 2022), glycine (Miller 2019), Protandim (Strong 2016), rapamycin (Harrison 2009, Miller 2011, Wilkinson 2012, Miller 2014) and 17α-estradiol (Harrison 2014, Strong 2016, Harrison 2021).”

3 Likes
#247

Most kinds of protein turn on mTOR. Yet in humans (not lab mice), high protein helps maintain and build muscle mass even in old age which is extremely beneficial for healthspan and lifespan. It makes more sense to up your rapamycin dose the older you get instead of limiting your protein intake.

8 Likes
#248

Evidence seems to say yes to a lot of the healthspan aspects

Also yes to avoiding (delayed) death from falls, etc in old age

My reading of the literature seems actually be no, not so for overall biological longevity / slowing down the aging clock

#249

For persons who supplement long-term with high dose zinc, I would recommend blood testing of copper levels and ceruloplasmin. Zinc can inhibit absorption of copper. Some people may be more susceptible to this than others.

I don’t know how it might affect absorption of trace minerals. Maybe there’s a study.

2 Likes
#250

I don’t know what anyone else does but I inject 200 picograms one time per week.
You are advised to do your own research to find the most appropriate dose for you.
I did notice that my blood phosphate level halved after a year on Klotho. It had been stable in the few years prior to that. I interpreted that as an improvement in kidney function. Blood phosphate generally increases with age.
Good luck!

2 Likes
#251

I started last week on my clomiphene experiment. Clomiphene, because I wasn’t paying close attention and bought clomiphene masquerading as enclomiphene from India. Unfortunately, I now have a several-year supply of the stuff.

I hope to avoid this side effect by being older ( :grin:) and taking a DIM, a diindolylmethane supplement that is supposed to regulate estrogen. Supposedly it helps to break down estrogen and improve estrogen metabolism.

I will be taking it to hopefully counteract some of the side effects of the clomifene I am taking. Most of the negative side effects come from raising estradiol levels.
However, skimming through several longevity sites and forums, the side effects seem to mainly affect the younger users of Clomid. The main negative side effects complained about are mental, depression, feeling “weird”, etc.

In any case, it seems to be a promising supplement for prostate health among other things,

“Helps prevent the effects of estrogen on cells
Slows some cancer cells
Lowers toxins produced by your body’s natural metabolism
Boosts antioxidants
Promotes weight loss
Enhances memory
Improves mood
Reduces symptoms of PMS
Supports cardiovascular health
Promotes good muscle development
Improves prostate health for men”

(Still, another supplement that does everything. :sweat_smile:)

“As we age, our bodies take longer to “clear” the estrogen in our cells and higher than healthy levels of estrogen are common”

It is also good for women:

“The evidence for a protective role of DIM against breast cancer continues to grow, but additional research is needed to further identify and refine the mechanistic targets of this compound, particularly in humans”

“Our data suggest that DIM enhances estrogen metabolism in TPD patients and can potentially serve as an antiestrogenic dietary supplement to help reduce the risk of developing TPD. The fact that DIM is detected in thyroid tissue implicates that it can manifest its antiestrogenic activity in situ to modulate TPD.”

“On average, 100 g of cruciferous vegetables contains up to 30 mg of glucobrassicin, which is estimated to convert to approximately 2 mg of DIM. May 30, 2016”
Probably more broccoli than I am willing to eat, though I do like broccoli.

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies - PMC.

https://www.liebertpub.com/doi/abs/10.1089/thy.2010.0245

6 Likes
#252

Fwiiw, this a huge part of the Blueprint diet by Bryan Johnson

2 Likes
#253

My wife relied on DIM for PMS symptoms. She said it made a huge difference.

1 Like
#254

This is @foundmyfitness’ current supplement stack

• Omega-3s (2g morning, 2g evening)

• Vitamin D (5,000 IU/day)

• Multivitamin (O.N.E. from Pure Encapsulations)

• Magnesium glycinate (~125 mg, Pure Encapsulations)

• Vitamin K2 (Life Extension)

• CocoaVia

• PQQ (20 mg/day, Life Extension)

• Alpha-lipoic Acid (Pure Encapsulations)

• Berberine (Thorne)

• Lutein and Zeaxanthin (Pure Encapsulations)

• Ubiquinol (100 mg/day)

• RENUAL from Pure Encapsulations

• Liposomal Glutathione (Pure Encapsulations, only weekends)

• L-carnitine

5 Likes
#255

If I only had Rhonda Patrick an information source I would eat plenty of broccoli sprouts and think high LDL is no problem basically since she never talks about it. One of the most important factor in longevity. And she never talks about it.

2 Likes
#256

You’re missing three very important ones, taurine, Lysine, Vit C. Even Johnson does those daily. Plus you Must take Metformin and acarbose if you want the best results in anti-aging. The rest you got are just fine. I also take, theanine, lithium, boron, DIM, zinc and copper in addition to most you have listed. Always do 2 day rests, no idea why but I just find it works well with me.

6 Likes
#257

I read a study awhile back and it was posted on here which said that Lutein and Zeaxanthin are much better absorbed from Goji Berries than from supplements. They got practically nothing from the supplements.

They taste like little raisins and I like them so much I planted one in a corner of my garden and it’s like a weed. Taking over.

7 Likes
#258

I agree with the rest period. I only take supplements 5 days a week, Saturdays and Sundays are rest days.

I ran several of my supplements through the half-life calculator and found I was probably accumulating too much in my system, so I think rest days are a wise thing to do.
Just look up the supplement half-life elsewhere and enter it into the calculator.

7 Likes
#259

I agree taking breaks is smart. Whether it’s avoiding accumulation or letting the body clean up the mess or whatever the reason, I feel better (emotionally) when I take a break. Plus I don’t like (I worry about) having too many high dose chemicals coursing through my body when I take rapamycin.

2 Likes
#260

Phenibut’s primary MoA is antagonism of the alpha2delta protein, which is an auxiliary subunit for voltage-gated calcium channels. This makes it most similar to drugs like gabapentin and pregabalin. There’s some evidence it acts at GABA-B (highly unlikely it acts at GABA-A), which would make it a pharmacological middle ground between baclofen and pregabalin/gabapentin.

Personally I think calling phenibut a nootropic in any general sense is a bit ridiculous, as I’ve used it quite a bit and it tends to impair learning/memory, quantitative reasoning, and abstract thought, especially with extended use (alpha2delta antagonism was also shown to impair cell-cell interactions necessary for synaptogenesis). Perhaps I could be extra sensitive to those negative cognitive effects, and I also concede that depending on the context, it could be acutely pro-cognitive due to modulating motivation, mood, or anxiety.

All that said, I’m actually quite the fan of phenibut as a day enhancer, so it’s sad to hear that LiftMode has discontinued it. Pregabalin is still quite easy to get though (despite being Rx only), and I actually much prefer it to phenibut, as it’s all the positives of phenibut, but more clear-headed and energetic, and also more potent.

FWIW I always preferred FAA phenibut as it tended to go easier on my stomach.

1 Like
#261

Thanks for the tip about Pregabalin.

The only reason that I refer to it as a nootropic is because YouTube nootropic gurus and the websites that sell it often refer to it as a nootropic.
I tried to find a source from India, but so far no luck.
It’s nice to have it around as I find it as effective as Zanax.
Fortunately, I don’t often feel stressed enough to need it.

#262

There’s probably no difference with phenibut and benzos when it comes to tolerance/addiction and yeah the nootropic term is just marketing.

See the subreddit of people quitting the drug. Benzo withdrawals are worse than heroin I’ve heard.
https://old.reddit.com/r/quittingphenibut/

#263

My nootropic stack:

  1. Phenylpiracetam (Nanotropil) - 100mg
  2. Vinpocetine - 10mg
  3. Mexidol (Emoxypine) - 125mg and/or Picamillon 20mg and/or Selank
  4. Ocassionally Semax - as anything that increases BDNF anectodally increases hair loss (although reversable when stopped). I noticed that so I don’t take it much.
    Highly recommend Semax 0.1 % for those with a higher risk of stroke or age related cognitive decline. For example, in Eastern europe Semax is carried on every ambulence and is admistered in the ER immediately to Stroke patients.
  5. Several eggs a day (must be pasture raised and corn and soy free) or Ocassional Alpha GPC - 300mg
  6. L-theanine - 200mg if I ever drink caffeine. I don’t tend to drink much coffee.
  7. Lithium Orotate - 1mg
  8. Have tried Zyn’s but stopped after a week.
6 Likes