There isn’t much curcumin in tumeric spice, unfortunately.
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I’ve switched to dihydro-berberine. I can’t say I’ve noticed a difference between berberine and dihydroberberine but I’m taking a lower amount because of the higher bioavailability. My new source might also be higher quality.
This paper from Healthspan is a deep dive on it.
Berberine comes with a long list of reported benefits from gut health to apoB to blood sugar. Now I’ve learned it lowers the senescent cell burden. It’s one of my 10 supplements although I don’t take it with metformin (only taken around rapa) or before exercise.
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Can you share your source for dihydroberberine?
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Metformin increases the lactate concentration during exercise. As far as I know, berberine works the same way? Have you noticed a negative effect when you do endurance training? Or have you measured lactates during training? Or is the half-life so short that it doesn’t affect exercise if you time it right?
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@tj_long Metformin dramatically increases the perceived effort of exercise. I can believe but have not measured my lactate to prove it but I have felt it very consistently. Peter Attia reported on this effect that he measured on himself.
I believe berberine would have the same effect if I took it before exercise but I avoid it. Berberine is know to up regulate AMPK by interfering with the electron transport chain. I don’t want that while I’m exercising intensely. Perhaps it would be like wearing a backpack filled with rocks while walking (rucking), so useful for increasing the effect of easy exercise.
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@Curious The Dihydroberberine i use comes from Endurance Products. $0.70/tablet. 1x/day.
“Dihydroberberine SR is a sustained-release dietary supplement featuring GlucoVantage® dihydroberberine, a highly bioavailable form of berberine. Easy-to-swallow 150-mg tablet dissolves over 5 to 7 hours for a slow, steady release of dihydroberberine.”
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how many people here have high iron in their system and I wonder if that has any correlation to anything positive other than all the negativity I have heard associatied with high iron? I know my iron level now is about 2x the standard maximum. Used to be 3x, and I have tested negative to hemachromotosis. Is it related to being overweight?
What do you guys think of this daily regiment…
1g calcium
500mg magnesium
20mg melatonin (before bedtime)
1g Astragalus
1.4g Resveratrol
100mg Fesetin
3mg Boron
Ashwagandha 1g
D3 7000 IU
K2 MK4 5mg MK7 600mcg
K1 1.5mg
Taurine 1g
NMN 1g
Metformin 1g
Allopurinol 900mg (for my high uric acid levels)
Acarbose 200mg (with each meal)
Except stated, everything is consumed after first meal of the day, for me, it could be breakfast or late lunch depending on what cycle I am in. I am trying out 18mg rapamycin once a fornight with 1.5L of GFT from next week… (I can’t be bother keeping half a bottle of GFT for 2 weeks… so I think maybe on the day, just finish the entire bottle prior to taking rapamycin)
The half-life in rats of dihydroberberine is ~3 hours. This might translate to a longer half-life in humans as many drugs are metabolized more rapidly in rats. I can’t find any studies about the half-life of dihydroberberine in humans. Perhaps you don’t need an extended release. Are your blood glucose levels high with regular dihydroberberine?
“displaying a half-life (t1/2) of 3.5 1.3 h and a maximum concentration (Cmax) of 2.8 0.5 ng/ml. Interestingly, in rats gavaged with dhBBR, BBR was also present in the plasma, displaying a longer t1/2 (9.6 2.1 h,”
https://sci-hub.se/10.2337/db07-1552
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Bicep
#528
That is a LOT of acarbose. When I wake up in the morning after acarbose I usually have a gut ache. I just need to eat something to make it go away.
You’re having 18 mg with GFT? of rapa? I don’t know what GFT is but if it has anything to do with Grapefruit, you’re taking way too much. I take either 3 or 4 with GFJ every 2 weeks. When I go higher I get high fasting glucose and very high lipids instead of just High lipids.
I was taking berberine with breakfast and dinner. Now I just take this lower dose extended release with breakfast. Seems like a good switch. I don’t use a CGM.
GFJ… .not GFT lol… I only get gas with acarbose, but I am bigger than you … about 110kg. If I suffer any discomfort, I take 2 active carbon pills. I take metformin and acarbose not because I need to but for the benefits.
I also forgot to mention that normally I only have 1 or 2 meals in a day… so not that much acarbose.
I plan to fast for 4 days after taking rapamycin. My lipids are low… never goes up… all i need to do is dont eat chocolates and I will be fine. Hard to fast on weekly basis. My job involves eating a lot lol.
It seems your dose of Resveratrol is quite high. At that high of a dose, it is causing cell apoptosis which is fine if you are fighting cancer, but as a daily supplement it is beneficial at 100-150 mg. I think you may be hurting yourself with such a large dose daily.
As for Boron, I may give it a go!
I dumped Fisetin as it is a weak senolytic and any benefit is probably negated by the more powerful senomorphics of Rapamycin or Taurine.
As for Taurine, I’d bump it up to 2-4 g daily.
I would dump the Allopurinol for a low dose SGLT2i. You’ll reduce uric acid and reap many other health benefits for around the same cost.
If your HBA1C is 5.5 or below, I’d reduce your Metformin dose to 500 mg as that seems to be an optimal level for non diabetics.
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Neo
#532
@DeStrider what’s the rationale on this point?
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Neo
#533
@DeStrider are you weighing this specific context here: At (very) high rapa intake there is a risk for rebound effects, and some have suggested that Metformin can help avoid the rebound
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@Neo Thanks for bringing Boron up. I read through the old link about it and it does sound like a good mineral to supplement at 3 mg. I may consider taking it due to thymus and prostate benefits! 
Thanks, I’ve learnt something new today.
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Neo
#535
Ok, I have a reason, to modulate my SHBG / free testosterone, so was curious if there was any new data/understanding/rationale
@John_Hemming have you changed your mind on boron/or it is based on not needing it based on bloodwork or other priorities?
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Metformin affects your HBA1C which can be affected by Rapamycin. Acarbose also helps. I am convinced that 500 mg of Metformin is beneficial, but studies show that higher doses like 2 g daily become detrimental. If your body doesn’t need the extra 500 mg for glucose control, it doesn’t seem necessary.
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Thx for the info. How do we know we are boron deficit? I’m taking it to help with the joint pain. Just 3mg each day.
As for taurine I consume a lot of red meat… That is why I didn’t increase it. Would I get the benefit to raise it to 2g still?
What is SGLT2i? Like Jardiance? Isn’t that a substitute for metformin or do we take it together?
Thank you for your suggestions.
I’ve changed my mind on Boron (Thanks @Neo ). 3 mg sounds great. I’m going to try it as well.
According to the Taurine guide, you should supplement 1 g for every decade you’ve lived, so a 40-49 yo should take 5 g. It’s a rule of thumb based on dosing conversions based on the famous mouse study.
Jardiance is an SGLT2I. It’s great for removing uric acid, protecting kidneys, losing weight, reducing HBA1C, protecting your brain and heart, etc… They’re wonderful. A low dose 10 mg is very inexpensive from India. I buy a 25 mg and split it in half as they are OK to split.
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