#102

Yes, I take Acarbose and Metformin. However I find that the glucose impact is mostly from the Metformin.

Before taking Rapamycin I took 1 g of Metformin daily for 4 years and never had a glucose problem. I guess I will go back to 500 mg daily.

2 Likes
#103

Off label use or your you were pre-diabetic?

#104

I have pretty high LDL and total C ( 163/238) and very low Trig (69) . I Tried Red Yeast Rice and it caused muscle pain and weakness couple of days after starting. Tried Ezetimibe as well but i started to get severe sinus issues (dont know if related). Atm not doing anything to control them. Would like to try statins but worried about the muscle pain similar to Red Yeast Rice.

#105

@ShawnF You can always quit the statin if it doesn’t agree with you. I started on low dose Atorvastatin then moved to 5mg rosuvastatin then shifted to every-other-day 10mg dosing. Now I don’t feel any aches but I suspect I do have negative impacts on my athletic performance. But my apoB is 60 and LDL-C is 71. It’s a fair trade.

3 Likes
#106

Thanks and fair point. I do have some in my medicine cabinet. I might just give them a try.

1 Like
#107

I have never been officially pre diabetic until now. All Metformin usage was off label.

1 Like
#108

One thing I like about my weekly tests is that from time to time I get a test artefact which in theory should worry me, but normally when it comes to the next week it is not an issue.

However, I accept that this approach would not work for everyone.

2 Likes
#109

My CGM readings have been so high the past two weeks that I reported the sensor as defective. The new one is also running high. Then I realized I started taking Zetia two weeks ago.

I have worn a CGM for a year, so I know my numbers well. This is a big increase. So it’s not always rapamycin’s fault.

#110

If you take Red Yeast Rice, you are taking a statin. Try Rosuvastatin.

#111

RYR in the usa has the statin taken out.

1 Like
#112

Desertshores, did you get this low LDL on Pantethine only, or combined with a statin other LDL lowering meds?

#113

FWIW

This has been mentioned before.

In my view.

If you are that concerned about your “cholesterol levels” just go and have plasmapheresis for lowering your blood level cholesterol.

Instead of creating damage/potential future damage by statins.

Using plasmapheresis for lowering cholesterol is a “no brainer.”

1 Like
#114

Or you trust the studies which show that statins is safe, effective, inexpensive and reduces risk of cardiovascular diseases instead of doing an expensive, experimental treatment which may not even work all that well.

Using plasmapheresis for lowering cholesterol is a “no brainer.”

You mean the people using it instead of statins have no brain.

5 Likes
#115

I was concerned about my lipid levels so I did this:
Lowered my rapamycin to 5mg/week
Took citrus bergamot
Took pantethine - 600 mg/daily
Increased my exercise to 6 times/week
Changed my TRF to 20/4
I had been doing everything but the pantethine for some time and my lipids were in the upper normal range. When I added pantethine they dropped to the lowest I have had in decades.
image

11 Likes
#116

Finally we have someone reporting on a supplement result that’s interesting, not the vague “my apoa-1/apob ratio is better, 10% decrease in ldl”. It would be interesting to hear what your apoB is though.

#117

I haven’t had an ApoB test done this year. The last one which I previously posted was about 10 months ago.

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3 Likes
#118

Desertshores, that is a great LDL number. Thanks for the info on the regimen.

#119

forgot to add, how much citrus bergamot did you take?

#120

And a good ApoB! I am envious.

#121

Not sure if this has been posted already - apologies if it has:

Coronary Atherosclerotic Plaque Regression: JACC State-of-the-Art Review, 2022

https://www.jacc.org/doi/10.1016/j.jacc.2021.10.035

Many interventions have plaque volume reducing effects.

Most notably:

  1. statins
  2. high dose statins
  3. ezetimibe
  4. PCSK9
  5. EPA, Colchicine, Pioglitazone…

  • 10-40mg Rosuvastation + Ezetimibe is an effective option. Most people will likely get 30-50 mg/dl LDL reduction at the highest doses.

  • If you want to go PCSK9 route, monthly 140mg Praluent is the most convenient and cost-effective (+ most effective towards lowering all cause mortality).

  • Nattokinase (at the dose of 10k FU) is also an option.

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