#426

Interesting but preprint from an OK-ish French uni. (btw, same author as these papers: What's the best statin to take? - #328 by adssx )

1 Like
#427

Out of curiosity, why do you think the Japanese and Korean studies are garbage?

#428

Interested to see what happens to your apob. Mine is lower since eating more beeswax policosanol, but it’s amongst multiple changes/factors.

If policosanol keeps your apob low it probably doesn’t really matter that RCTs don’t exist comparing it head to head with Rosuvastatin.

#429

Because one study is merely a review of small studies. The next one has a
small cohort base.

4 Likes
#430

The Breakfast of Champions:

“… I remember one of the first times he stayed at our house and he opened up a package of Oreos to eat for breakfast. Our kids immediately demanded they have some, too. He may set a poor example for young people, but it’s a diet that somehow works for him.””

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#431

Thanks for that info Desert man…, useful ! Saved me from a mistake !

#432

Here is a calculator using C-peptide:
https://www2.dtu.ox.ac.uk/homacalculator/

None of these models are all that great to measure insulin resistance anyway? @Neo @adssx

What values are good for %B, %S, IR? (different for model using c-peptide vs. insulin?)

Couldn’t really find a insulin resistance thread so posting it here, because related to possible statin side effects.

#433

Could be a good thread to start.

For me I wear a CMG 40% or so of the time and that helps understand a lot of relevant things. Even if you just get a 14 or 28 days pack you might want to consider that.

You can also do a OGTT with insulin checks every 20-30 min during those same 2-3 hours.

Making it a routine to ask for your insulting when doing routine blood work will also help create a picture over time, combined with HbA1c, IGF-1, triglycerides, etc.

3 Likes
#434

I thought that HOMA-IR was a good model. That’s what my doctor uses. Do we have papers suggesting that it’s not good or that there are better metrics?

Levels give the following ranges:

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image1920×2744 215 KB

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#435

I read in a Peter Attia article about this, I think it is paywalled, but he uses OGTT which seemed much superior based on what he said.

#436

Yes OGTT is great but it takes 2 to 6 hours. I did both (2h and later 6h) and it was a nightmare. You can’t do that regularly. So I only do HOMA-IR every 6 months now.

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#437

If your LDL is 70 why are you taking a statin? HDL 40 is not good.

#438

Cause at 70mg/dL you can still have CVD
40mg/dL of HDL is okay for a man. Not amazing, just okay.

1 Like
#439

But your LDL 70 is not great, but also is OK. Not sure about HDL 40. May be too low? Trying to get my LDL 70. Mine is 95. Started alternating ezetimibe and rosuvastatin in lowest doses.

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#440

Atherosclerotic coronary plaque regression from lipid-lowering therapies: A Meta-analysis and Meta-regression 2024

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image1161×886 115 KB

while the addition of ezetimibe seemed to significantly increase the PAV reducing effect of LIS while decreasing the PAV reducing effect of HIS, these inconsistent results were driven by the significant heterogeneity in the LIS plus ezetimibe subgroup (τ2 = 0.88, I2 = 61.8%), and possibly the limited number of included studies in the HIS plus ezetimibe subgroup. In fact, previous studies demonstrated that the addition of ezetimibe do not contribute to a significant increase in PAV reduction. While the role of statins on plaque regression have been discussed above, we emphasize that HIS was the only LLT subgroup which provided significant reductions in both TAV and PAV.

Perhaps, the more significant finding of our study in PAV reduction is the role of EPA. […] While many previous studies have demonstrated that the addition of EPA to statin contributes to increased plaque regression, our pooled analysis showed that the addition of EPA to LIS is superior even when compared to other multiple classes of LLTs, supporting the hypothesis that EPA contributes to plaque regression in mechanisms beyond lipid-lowering, giving emphasis to the role of its anti-inflammatory effects in plaque regression. However, the question on whether the overall results translate to a clinically meaningful reduction still remains.

They didn’t define LIS and HIS though :thinking:

Bempedoic acid not included in the review. Would be interesting to test low-intensity statin + ezetimibe + EPA (+ bempedoic acid?). Or just wait for obicetrapib…

4 Likes
#441

V.Interesting. Do you have a link to full paper?

I think this is particularly notable: " Compared to high-intensity statin monotherapy, moderate-intensity statin with ezetimibe combination significantly reduced the risk of composite outcome [hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.77–0.92, P < 0.001]"

1 Like
#442

I pasted the wrong link :grimacing: Now fixed…

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#443

17105896519515705693763805565061
171058965195157056937638055650611920×1440 196 KB

Ezetimibe 10mg, pravastatin 10mg!
Pretty good!
HDL 60
LDL 53
Triglycerides 37
GGT 8
ASAT 27
ALAT 25
CRP below 1

6 Likes
#444

Below is interesting for perspective on CAC scores

IMG_7054
IMG_70541110×874 129 KB

https://twitter.com/paddy_barrett/status/1768924452484456513?

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#445

I have switched to 10 mg Lipitor (atorvastatin) from 5 mg Crestor (rosuvastatin) because of lower causal diabetes risk and cataract surgery: Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial (2023)

Whether I will increase the dose or not, dunno, it is a separate question.

2 Likes