#1

Hey guys, I’m gonna interview Matt next week. As you may know he’s done some work with rapa on mice, dogs and humans as well. So I was wondering what topics you’d bring up/questions you might have from him that I’d ask during our conversation?

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#2

When can we expect any results (preliminary is fine) from the TRIAD study (Test of rapamycin in aging dogs) as part of the Dog Aging study?

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#3

“Did you initially decide to take Rapamycin primarily for its potential Longevity benefits, or were you motivated more by specific health conditions (such as your frozen shoulder)? More broadly, would you recommend Rapamycin to otherwise healthy individuals who are interested in it solely for Longevity purposes?”

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#4

I believe that Matt K has said before on his Optispan podcast that he recommends taking rapamycin in a fasted state vs with high-fat meal. It would be nice to confirm on that point and his reasoning and if he has any data to show which administration route might produce better results?

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#5

  1. How many clients does Optispan currently have?

  2. What are the current annual costs to enroll in the various Optispan options? Why do you hide pricing?

  3. What happened to the Optispan corporate wellness offering?

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#6

What is Matt’s opinion on this combination of drugs: A Combination of Rapamycin and Trametinib Extended Maximum Lifespan by up to 35%

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#7

Hi, long-time lurker, registered for an account to reply to this thread. A couple questions come to mind:

How does Matt think about the definitive human Rapamycin trial? If he were to design a study (with sufficient but realistic funding) how would he design it? What endpoints, aside from mortality, would he be interested in? What would the inclusion criteria be, specifically with regard to age?

A large portion of popular longevity content focuses on the anabolism / catabolism vector (I am not sure if ‘pathway’ is the right technical term here). Are there other key ‘vectors’ that Matt could talk about here that might be less discussed in popular media? I know this is a complex topic and many mechanisms interact; I’m mostly looking for additional lenses that can be used to assess potential interventions.

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#8

I may be mistaken, but I’m pretty sure Matt has commented on that trial before - short-lived controls meant he was skeptical it’d be repeated…?

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#9

Oh yeah, I’m an evil anarcho capitalist, I’m definitely gonna ask these ones!

#10

I think I need to tread carefully with this one? For some reason he walked away from the Dog Aging study, right?

#11

No - I believe he’s still involved somewhat, though his relationship may be a little different because he left U. Washington.

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#12

Actually, He’s still the director of the Dog aging project - He talked a little about it at Vitalist bay when I saw him there a few months ago - see his presentation here: Vitalist Bay, a Pop-Up City in the SF Bay Area - #47 by RapAdmin

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#13

He mentioned that he is considering 2.5mg Tadalafil daily.
Ask him to outline the reasons and any associated risks.

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#14

Yeah I just watched that yesterday. I duked it out with ChatGPT and turns out it was hallucinating. Now I’m a fool.

#15

What available drug/supplements might be complementary to Rapamycin in terms of mechanism of effect on health span?. What combinations might he think could be most effective. What should we avoid taking with Rapamycin? (I am particularly interested in drugs/supplements that could have side benefits for individuals with Long Covid, atherosclerosis and/or poor glucose metabolism.)

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#16

I’ll second these two questions on what which supplements would compliment, vs be redundant, vs what we should avoid, even if it’s only on rapa days.

#17

You wrote: He mentioned that he is considering 2.5mg Tadalafil daily.

Ask him to outline the reasons and any associated risks.

Maybe this is a question for Tammy Kaeberlein… :laughing:

#18

FWIW, I believe he mentioned tadalafil when discussing the study that looked at the association of medications people took and lifespan - drugs that showed life prolonging association in the UK Biobank study. There were a handful of such drugs, including atorvastatin, a couple of vaccines, and viagra. Tadalafil is a sister drug to viagra, but longer lasting in the body. So MK thought that interesting enough of a longevity signal to consider taking… so not so much for the sake of his wife as much as his life🤪.

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#19

Ask him to discuss mitochondrial transplantation and the energy theory of aging.

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#20

  1. What would be rapamycin schedule with iron-deficient low hemoglobin? Can rapamycin have a hormetic effect?

  2. What does he think about 3mg per week dosage of rapamycin?

  3. For starters, is it necessary to start with lower dosage and increase gradually (e.g. 3 to 5 mg)?