#226

More like look for the black cat in the dark room.

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#227

I have just upped my dosage to my target of 6 mg + GFJ + EVOO biweekly. I have been hit with euphoric fatigue after a few hours of dosing and it has continued for over 24 hours. It really helps with a good nights sleep. The best way to describe the feeling is that feeling you get after sex, when you just want to sleep yet feel so satisfied. Personally, its a good side effect and I hope it continues although I have less energy. Not sure whether I should hold at this level or reduce. This should be an equivalent of about 20 mg, IMHO.

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#228

I get this as well, with doses 6mg + , just feel tired but its a good tired and I do sleep well. Usually last 48 hours after dose, first 24 hours I have the most fatigue.

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#229

I think Dr. Green is back to lower doses on a weekly basis. One point to remember is that the bioavailability of rapamycin seems to be higher for females than males. This may also explain why it works better for females than males in some of the mouse studies.

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#230

I think Dr. Green is back to lower doses on a weekly basis.

Lower as in…?

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#231

So, as a female, age 62, are you taking ~16-18 mg weekly or biweekly? If you are, have you had side effects?

I’m an almost 59 y.o. female. I was going to work up to 5 or 6 mg weekly (side effects permitting). But without any clear mg per kg of body weight guidance it all seems like a shot in the dark. All of the comments so far have focused solely on the question of something like how much mTor suppression one requires. But no one seems to have any interest or insight into the metabolic question of absorption, immune-suppression and the wash-out process depending on body mass/fat composition and so forth.

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#232

So I just received the Rapa, and am diving back into the protocols. Thank you for sharing your experiences, it is very helpful to know when you upped your dosage and added GFJ. You may have seen this research regarding folks 65 starting on 5mg weekly with what looked to be de minimis side effects. (https://health.uconn.edu/aging/wp-content/uploads/sites/6/2016/04/mTOR-inhibition-improves-immune-function-in-the-elderly.pdf) The study lasted 6 weeks, there were 40+ subjects in the 5mg camp and 2 got a mouth ulcer.

I also found this i/v of Matt Kaeberlein extremely helpful as it just cut to the chase, Rapamycin and aging: Dosage, side effects, and success stories | Matt Kaeberlein - YouTube and particularly his comment that…“I’m just gonna say it, the side effects of rapa are less than exercise.” The other take-aways were: 1) Dosage 3mg-6mg reasonable (based on the Joan Mannick study of elderly participants taking 5mg weekly for 6m w/ few side effects (https://health.uconn.edu/aging/wp-content/uploads/sites/6/2016/04/mTOR-inhibition-improves-immune-function-in-the-elderly.pdf), this is probably more relevant to older folks as it appears there is a greater tolerance for rapa with age; 2) Most people don’t cycle. 3) Anecdotal evidence re: age-related physical complaints, including his frozen shoulder for which he took rapa weekly with plan to cycle at 10-12 weeks, but shoulder had cleared up with no side effects from rapa.

So based on the above, I am considering starting at 2mg/weekly and going from there. Re: my 18# 13Y old Chiwennie, who will be my co-pilot, I have calculated at .5mg weekly to start. I would be most grateful if anyone had any further insight regarding his dosage to share.

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#233

I thought similarly after reviewing everything. Got mine 10 days ago. Took 1 mg first week and then yesterday decided to go straight to 3 mg for second week. I’ll increase to 5 within 2 weeks-- side effects permitting. So far I haven’t noticed anything except that I’ve gained 3 lbs. That’s NOT desirable. But could be unrelated to rapa.

#234

I thought similarly after reviewing everything. Got mine 10 days ago. Took 1 mg first week and then yesterday decided to go straight to 3 mg for second week. I’ll increase to 5 within 2 weeks-- side effects permitting. So far I haven’t noticed anything except that I’ve gained 3 lbs. That’s NOT desirable. But could be unrelated to rapa.

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#235

I’m on 24 mg every two weeks.

My blood pressure, insulin, glucose, ldl all good.

Unfortunately my lipoprotein a is high.

Am considering raising my rapamycin dose given no issues with current dose. Perhaps to 28 mg or 30 mg every other week to offset genetics.

Any thoughts?

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#236

How about lymphocytes? Are they holding normal?

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#237

Lymphs (absolute) has been stable at 1.1 for a while (range: 0.7 to 3.1). Lymphs have been between 28 and 32 (no established range) for the past year. My WBC has been on the lower end of the range (3.4 to 10.8) for years… from 3.4 to 4.5 over past few years.

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#238

You might want to take a look at this post by @rivasp12 on the doctors’ sub-forum:

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#239

I started week #1 on 2mg
Week #2 (this week) went to 3mg with no issue.
I’m planning to keep upping the dose until 5mg based on the Joan B. Mannick study I cited above, along with MK i/v, also linked above, stating the established range for folks is 3-6mg.
Haven’t noticed any side effects good or bad at this point.

For my co-pilot chiwiennie, I kept him at .5 since he can’t tell me how he’s feeling.

He’s ~ 18lbs. I would like to get him to 1mg, and am looking for research to support this for him.

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#240
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#241

Cryotherapy is pretty amazing unfortunately I have to drive 35 minutes each way for a 3 minute treatment.

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#242

Should we repeat the user survey- the original one was done a while ago, October 2021. We since have had a lot of new members.

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#243

I concur this. I am just starting my rapamycin journey and would be great to see new results as reading this forum you get so many different protocols, reasonings etc… it gets confusing.

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#244

It seems like the dosage is highly personalized. Even those who get blood levels tested really don’t know the optimal number to aim for. We are all guessing.

My guess is abou 9 mg weekly. And go on a 20mg bender every now and then.

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#245

yes, but why weekly not bi-weekly? or 10 days apart?

I understand that it is highly personalized, that side effects should be minimal and positive or wanted effects maximized… so playing around is what you suggest? :sweat_smile: It is hard to tell that to a very controlling person who likes things clear and sound :joy: :rofl:

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