#21

Alzheimer’s

Review Dr Mary Newport, M.D

#22

I use these daily:
Magtein (magnesium threonate)
Cognizin (Citicoline)
Theanine
Omega 3
Lithium
Caffeine

#23

The top of my list is:

  • Exercise
  • Living a low stress life
  • Social contacts

Evidence of neuroprotection is very strong for these.

The list of supplements (loosely) for which there is evidence of neuroprotection in large. I find reasonable evidence for the following (in declining magnitude):

  • DHA/EPA*
  • Curcumin*
  • Resveratrol*
  • Caffeine*
  • CoQ10*
  • Creatine
  • GLP-1 Agonists
  • NR
  • B6, B12, Folate*
  • NAC*
  • Cannabinoids
  • Melatonin*
  • Polyphenols*

I take the supplements with an asterisk regularly or occasionally. Many of these bullets deserve footnote discussions.

2 Likes
#24

Rob - what are your thoughts on SGLT2’s, Telmisartan, Blood pressure optimization, optimizing insulin sensitivity, Vitamin D, lipid optimization.

1 Like
#25

You are right! This discussion thread defines more than one slippery slope in that the circulatory environment is no more than one degree away from being neuroprotective, which slopes into questions on metabolism, lipids, kidney and liver health, and so on.

Your mention of telmisartan seems especially important in my opinion. I should have included it in the list. I think it is turning out to be a sleeper wonder drug. The more we learn about it the better it looks. Chronic activation of the renin-angiotensin system contributes to neuroinflammation, oxidative stress, and cerebrovascular dysfunction (including impaired blood flow), all of which are implicated in neurodegeneration. Evidence is good that activation of PPAR-γ reduces neuroinflammation, protects against mitochondrial dysfunction, and decreases the accumulation of amyloid-beta in the brain with potential effects on Alzheimer’s pathology (although I think Tau defines a more direct path). And this is the short list. We need more longevity focused human trials that parse out the direct BP causal chains.

2 Likes
#26

Doc, do you find this dosage of methylene blue to be sufficient? I’m 100 lbs, and I’ve been taking 13 drops in the AM and 13 in the evening before light therapy. Any difference in absorption between pill form and liquid, in your opinion? The liquid tastes awful so I have to mix with a little juice (not good for my ketones but good for my sanity). :laughing:

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#27

I guess I have to convert to mg to compare apples to apples. :wink: thx for the info.

#28

Brain Health and Omega 3:

  • DHA neuroplasticity
  • EPA anti-inflammatory
  • Key though, need Vit B, to show benefit per the study in the video (timestamp 4:01)
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#29

A recent meta analysis that concludes the opposite: Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials 2024

Single vitamin B (folic acid [FA]: SMD = 1.21, 95% CI = [0.87, 1.55]) supplementation may be more effective than multiple nutrients (FA and vitamin B12: SMD = 0.71, 95% CI = [0.41, 1.01]; and FA combined with docosahexaenoic acid [DHA]: SMD = 0.58, 95% CI = [0.34, 0.83]) in global cognitive function.

I’m not sure there’s a one size fit all answer: it might depend on the form of each vitamin (e.g., is methyl-B12 the same as cobalamin?) and each individual (based on blood test).

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Omega-3 Needs B Vitamins for Benefits (Dementia Prevention)
Omega 3 makes me depressed: why?
#30

Neurofeedback plus photobiomodulation for brain with helmet, both based on results from QEEG.
Exercise
CRON with at least 1.2 kilos of fat fish per week
Peptides cerebrolysin and semax.
Magnesium threonate

1 Like
#31

alpa lipoic acid (ALA) is neuroprotective, it’s also dirt cheap and as far as I can tell has no adverse effects (up to 1600mg/day). It is used to treat diabetic neuropathy.

“Yes, alpha-lipoic acid (ALA) has been shown to have neuroprotective effects: Brain protection
ALA can cross the blood-brain barrier and may help protect the brain and nerve tissue.
Neurological disorders ALA is commonly used to treat neurological disorders and….” From google search using alpa lipoic acid neuroprotective

Just do a search using “alpa lipoic acid neuroprotective” as terms

I use it for its anti-proliferative cancer effects as I have prostate cancer. I just buy the bulk via Amazon and load it into 000 capsules which gives me about 400mg/capsule.

3 Likes
#32

No, no, he means Calais, France, very nice beaches… :smiling_imp:

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#33

I think Prof. Mark Mattson would argue for time restricted eating as well due to increasing BDNF. Exercise for sure as well as TRE. I do the others on your list except for eggs, although not arguing that you shouldn’t. Clearly want a diet that preserves microvascular circulation.