Plasmogens from Prodrome such as Neuro and Glia oil products. Peter Diamandis has started taking this. Research on cognitive health looks promising.
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Bicep
#15
I thought @CronosTempi might mention it because of the video posted. Clearly lutein is an important neuroprotective agent. Also an IL-11 inhibitor and longevity supp.
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Methylene blue, perhaps? My husband has been taking it for 2 weeks and going to a spectrum light therapy capsule at least 3 to 4 times a week (7 wavelenghts including 660nm). Results so far? Increased energy even after a restless night due to some issues with our senior dogs, improved mood, chronic tinnitus gone, recent surgery scar disappearing quickly, and eczema healing nicely. And the best part: blue mouth, tongue, and urine. 
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Well, yes, I could’ve mentioned lutein, but he was talking specifically about PD when he counted off all those that affected PD, but didn’t mention TD/TDAP.
But yes, there’s a whole bunch of neuroprotective agents, however as I mentioned in the lithium thread, my issue is with tightening up the definition of what neuroprotection is and how do we measure it. So, if you say, protects against PD, that’s a tight definition. But when you say things like “makes the brain 6 years younger”, as in that notorious thread I have chosen not to participate in, then I find that extremely handwavy, laden with assumptions and suppositions, and of dubious validity - just think of how broad a physiologic category “younger brain” is, and if picking a handful of arbitrary markers really encompasses the totality of that claim.
Same with “neuroprotective” - too handwavy. Something concrete, like “wrt. PD”, ok, but otherwise it’s too much hot air. YMMV.
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Drugs? I don’t know. But here is stuff to ponder…
“Good for the heart? Good for the brain”. Is the old way of thinking about it. The new new thing is gut health: “Leaky gut? Leaky BBB.”
Eat for a healthy gut microbiome (lower inflammation) and exercise to build mitochondria, lower BP, reduce inflammation
I think good sleep to let the glymphatic system do its job has to be mentioned as well.
Watch for iron overload. Iron is associated with neurological diseases.
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curt504
#19
All background can be found on youtube for these peptides. Lots of evidence for protective as well as restoritive benefits from PTST/TBI cases;
Peptides: cerebrolysine, semax / selank. Plus the anti inflammatory; BPC-157 + TB-500.
Part of brain/neuro protection is low/lowering inflammation. I would put the ketogenic diet where measured ketones (ketomojo meter) are >>1.0 ideally into 2.00+ (difficult). Soo soo many cases of restoration where ketones are held >2.0. For normal folks just getting ketones into 1.0 + ;periodically is protective.
Alzheimer’s is often called type 3 diabetes so low glucose + low insulin is highly protective.
We wear a CGM 80% oof the time as a traffic cop an make sure our glucose (thus insulin) stay low. My wife tests ketones daily…
IMHO diet; ketogenic diet is 10x, maybe much more then 10x more effective then any of the nutricals mentioned. Then the peptides then the nutricals.
Good luck, curt
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DrFraser
#20
There is a good option on Amazon of a 12 mg capsule to avoid tongue and teeth issues.
I personally feel it makes a significant difference in mentation, and take 1 capsule every AM, and days I work in the ER take 1 mid day.
I don’t know if this is neuroprotective, but it certainly seems to enhance brain function, as does NAC Ethyl Ester.
@约瑟夫_拉维尔 I think gut health is critical, and looking at a test like KBMO has for looking at whether you have altered gut permeability is a sensible approach. But once you’ve cleaned your diet up, it would seem like the items @adssx has mentioned all make sense.
@curt504 Interesting on the keto diet - I guess it depends on diet quality - and it is difficult to craft a keto diet that doesn’t increase every other part of mortality, from vascular disease to cancer. Yes the brain uses either ketones or glucose for energy - my approach is to maximize insulin sensitivity in the brain with things like GLP1’s and SGLT2-i. I’ve not seen any convincing evidence showing a keto diet is helpful for neurocognitive decline, but I’d love to see some, if you find any. Overall, I pursue a diet rich in polyphenols and complex carbohydrates - a typical WFPB, which I believe the evidence supports this approach. Naturally making sure one optimizes Omega 3 index, Vitamin B12 and Homocysteine.
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约瑟夫
#21
Alzheimer’s
Review Dr Mary Newport, M.D
I use these daily:
Magtein (magnesium threonate)
Cognizin (Citicoline)
Theanine
Omega 3
Lithium
Caffeine
RobTuck
#23
The top of my list is:
- Exercise
- Living a low stress life
- Social contacts
Evidence of neuroprotection is very strong for these.
The list of supplements (loosely) for which there is evidence of neuroprotection in large. I find reasonable evidence for the following (in declining magnitude):
- DHA/EPA*
- Curcumin*
- Resveratrol*
- Caffeine*
- CoQ10*
- Creatine
- GLP-1 Agonists
- NR
- B6, B12, Folate*
- NAC*
- Cannabinoids
- Melatonin*
- Polyphenols*
I take the supplements with an asterisk regularly or occasionally. Many of these bullets deserve footnote discussions.
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Rob - what are your thoughts on SGLT2’s, Telmisartan, Blood pressure optimization, optimizing insulin sensitivity, Vitamin D, lipid optimization.
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RobTuck
#25
You are right! This discussion thread defines more than one slippery slope in that the circulatory environment is no more than one degree away from being neuroprotective, which slopes into questions on metabolism, lipids, kidney and liver health, and so on.
Your mention of telmisartan seems especially important in my opinion. I should have included it in the list. I think it is turning out to be a sleeper wonder drug. The more we learn about it the better it looks. Chronic activation of the renin-angiotensin system contributes to neuroinflammation, oxidative stress, and cerebrovascular dysfunction (including impaired blood flow), all of which are implicated in neurodegeneration. Evidence is good that activation of PPAR-γ reduces neuroinflammation, protects against mitochondrial dysfunction, and decreases the accumulation of amyloid-beta in the brain with potential effects on Alzheimer’s pathology (although I think Tau defines a more direct path). And this is the short list. We need more longevity focused human trials that parse out the direct BP causal chains.
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Doc, do you find this dosage of methylene blue to be sufficient? I’m 100 lbs, and I’ve been taking 13 drops in the AM and 13 in the evening before light therapy. Any difference in absorption between pill form and liquid, in your opinion? The liquid tastes awful so I have to mix with a little juice (not good for my ketones but good for my sanity). 
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I guess I have to convert to mg to compare apples to apples. 
thx for the info.
Jonas
#28
Brain Health and Omega 3:
- DHA neuroplasticity
- EPA anti-inflammatory
- Key though, need Vit B, to show benefit per the study in the video (timestamp 4:01)
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adssx
#29
A recent meta analysis that concludes the opposite: Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials 2024
Single vitamin B (folic acid [FA]: SMD = 1.21, 95% CI = [0.87, 1.55]) supplementation may be more effective than multiple nutrients (FA and vitamin B12: SMD = 0.71, 95% CI = [0.41, 1.01]; and FA combined with docosahexaenoic acid [DHA]: SMD = 0.58, 95% CI = [0.34, 0.83]) in global cognitive function.
I’m not sure there’s a one size fit all answer: it might depend on the form of each vitamin (e.g., is methyl-B12 the same as cobalamin?) and each individual (based on blood test).
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Ulf
#30
Neurofeedback plus photobiomodulation for brain with helmet, both based on results from QEEG.
Exercise
CRON with at least 1.2 kilos of fat fish per week
Peptides cerebrolysin and semax.
Magnesium threonate
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Justin
#31
alpa lipoic acid (ALA) is neuroprotective, it’s also dirt cheap and as far as I can tell has no adverse effects (up to 1600mg/day). It is used to treat diabetic neuropathy.
“Yes, alpha-lipoic acid (ALA) has been shown to have neuroprotective effects: Brain protection
ALA can cross the blood-brain barrier and may help protect the brain and nerve tissue.
Neurological disorders ALA is commonly used to treat neurological disorders and….” From google search using alpa lipoic acid neuroprotective
Just do a search using “alpa lipoic acid neuroprotective” as terms
I use it for its anti-proliferative cancer effects as I have prostate cancer. I just buy the bulk via Amazon and load it into 000 capsules which gives me about 400mg/capsule.
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Justin
#32
No, no, he means Calais, France, very nice beaches… 
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I think Prof. Mark Mattson would argue for time restricted eating as well due to increasing BDNF. Exercise for sure as well as TRE. I do the others on your list except for eggs, although not arguing that you shouldn’t. Clearly want a diet that preserves microvascular circulation.
