Vaccines for longevity

[jnorm]

I got the flu shot for the first time last week. Ended up going to Costco and it was pretty easy, and it only cost $20 out of pocket.

Planning to get the Gardisil 9 as well, I believe it comes in at ~$280/dose at Costco.

[AnUser]

I’ll be getting:

Whooping cough
Flu
Pneumococcal
Shingles (if I can)

Can’t get COVID vaccine atm for my age group or I would probably get it as well.

[dicarlo2]

I’m curious if people plan to get all vaccines at once or spread them out (eg one weekly). I tend to have a pretty bad reaction to the covid vaccine, so I’m a bit concerned about “overstimulating” my immune system with multiple vaccines at once. I’m not confident this is a realistic concern though.

[CronosTempi]

I got hep b Aug 14, then covid & flu together two weeks later Aug 28, then almost two months later pneumonia Oct 24, then almost a month later tdap Nov 20, and I’m planning hep a on Dec 11, so 3 weeks later. All this prior to starting rapamycin in January of 2025, wanted to get all my vaccinations out of the way. Next year only the standard flu and covid vaccines.

[jeanbaptiste]

When I did mine it was 3 at the same time (hepatite A and B, gardasil 9 + DTP). No side at all!
Pharmacist said it was ok and design to be used at the same time without problem.

[AnUser]

@AnUser

Whooping cough
Flu
Pneumococcal
Shingles (if I can)

Can’t get COVID vaccine atm for my age group or I would probably get it as well.

I got whooping cough and flu vaccine. Pneumococcal the nurse recommended not to take at the same time because of increased risk of side effects. It was good I guess I didn’t ask for Shingles also at the same time.

If they only allowed me to take all the vaccines (including COVID)… I say it like Jiankui He!

[adssx]

Interesting recent updates on national guidelines: Vaccines for longevity - #25 by adssx

• US: US CDC recommends expanding pneumococcal vaccines to adults aged 50-64: “The agency’s Advisory Committee on Immunization Practices voted 14 to one in favor of lowering the age for adult vaccination, which the CDC said gives more people the chance to protect against the disease at ages when the risk of infection increases substantially.”
• Australia: The Government has expanded access to GSK’s shingles vaccine, Shingrix, to cover individuals aged 18 to 64 years who are at a moderate to high risk of herpes zoster as advised by the ATAGI.

Got the flu vax last month. Chose not to get the Covid vax due to uncertainty on the risk/benefit ratio… caught Covid the week after Got my second HPV dose this morning. I’ll try to get the pneumococcal one.

[AnUser]

@adssx

I’ll try to get the pneumococcal one.

Have you looked at any info of starting with the Pneumococcal conjugate vaccines (PCV) and then boosting 8 weeks or later with Pneumococcal polysaccharide vaccine, PPSV23? That’s what I’m thinking about now.

There’s a new PCV vaccine CAPVAXIVE by Merck that’s 21 valent.

CAPVAXIVE™ (Pneumococcal 21-valent Conjugate Vaccine) | Official Patient Site

It seems Capvaxive is covering 11 different strains compared to Prevenar 20.

[adssx]

@AnUser

Have you looked at any info of starting with the Pneumococcal conjugate vaccines (PCV) and then boosting 8 weeks or later with Pneumococcal polysaccharide vaccine, PPSV23? That’s what I’m thinking about now.

France updated its recommendation last year and said that PCV20 was better than PPSV23, so I would go for PCV20 (they didn’t analyze PCV21): Haute Autorité de Santé - Stratégie de vaccination contre les infections à pneumocoque - Place du vaccin pneumococcique polyosidique conjugué (20-valent, adsorbé) chez l’adulte

The US CDC seems to agree: Pneumococcal Vaccine Recommendations | Pneumococcal | CDC

Administer PCV15, PCV20, or PCV21 for all adults 50 years or older
If PCV20 or PCV21 is used, a dose of PPSV23 isn’t indicated.

PCV21 (Capvaxive) is very recent, only got FDA approval in June this year. Merck notes that: “There are currently no studies comparing the efficacy of CAPVAXIVE and PCV20.” (source: Merck’s CAPVAXIVE™ (Pneumococcal 21-valent Conjugate Vaccine) Demonstrates Positive Immune Responses in Adults with Increased Risk for Pneumococcal Disease October 2024)

So I would wait for data on PCV21 vs PCV20. And see if other countries approve PCV21.

[RapAdmin]

An interesting new video by Mike Lustgarten and his guest:

Viruses Contribute To Aging And Age-Related Diseases: Amy Proal, PhD

[Bicep]

Lustgarten is a genius, he does it repeatedly. They didn’t talk about ivermectin, but it was shown to have antiviral activity against several of the species he was talking about. I may have posted that paper here, at the time it was probably unpopular and now I don’t know where it is. The other thing I thought of was some of Stamets mushrooms that have antiviral activity.

Great post, thanks !

[desertshores]

I hesitate to drop this here, but since ant-viral activity seems to be the topic, I must mention my old friend methylene blue.
It is a tad safer than ivermectin and is available without a prescription. (Just be sure to get usp grade)

“Yes, methylene blue has antiviral activities.
Methylene blue has demonstrated broad-spectrum antiviral properties against various viruses, including SARS-CoV-2, H1N1 influenza virus, Zika virus, Dengue virus, and others. Studies have shown that methylene blue can inhibit viral replication and entry at low micromolar concentrations, both in the presence and absence of light activation.
For instance, Cagno et al. reported that methylene blue exhibits potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus without the need for UV activation.[1] Similarly, Chuang et al. found that methylene blue inhibits the protein-protein interaction between the SARS-CoV-2 spike protein and ACE2 receptor, thereby blocking viral entry and replication.[2] Additionally, Li et al. demonstrated its efficacy against Zika and Dengue viruses by inhibiting viral protease activity and reducing viral production.[3]
These findings suggest that methylene blue could be a promising candidate for repurposing as an antiviral agent, particularly given its established safety profile and FDA approval for other indications. Further clinical studies are warranted to confirm its efficacy and safety in treating viral infections.”

Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1...

Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in...

[Bicep]

She mentioned it on the video. I have used it a couple times now, need to increase the dosage since not much is happening. I didn’t want to start big.

[EenDwaze]

FWIW l have found methylene blue to be very effective for most infections (but not all). I typically use 40 to 80 mg once a day for mild infections and 40 to 80 mg 3x a day for more severe infections. I’m definitely a fan.

[shc]

This is a great video, thanks!

After having gotten almost all the vaccines that are there to be gotten (only dengue, malaria, and rsv remaining), I should probably start considering some of the safer antivirals mentioned in the video.

[Beth]

Tangent coming:

When I went to Kenya years ago, I got a ton of those too, and I even tacked on rabies for some crazy reason… I felt like crap for months!

And then the CDC tracked me down and told me I was exposed to rabies from a baby zebra I was petting. (It was quite impressive to see how hard they were trying to talk to me after I kept ignoring the call thinking it was junk)

I found it interesting to learn they said I’m most likely covered for rabies for life, but if there was a saliva exchange, they would have me err on the side of caution and just get an extra vaccine.

After learning that, my new vet was pressuring me to get updated rabies vaccines for my indoor only cats. I said you can do a titer and if not still covered, I’ll give them a vax (I avoid vaccines for them only because they have almost zero exposure)… well, after a decade, their rabies coverage was still in almost full force!

Just an interesting sidebar

[Satchel]

I am a veterinarian and they give you a rabies vaccine on your first day of vet school. Titres for 15y afterwards were always protective-with just one rabies vaccine. My wife last month received 5 weekly rabies vaccines after a rabid bat bite-she is knocked sideways, but I bet she is protected for life

[Beth]

WOW, I’ve never known anyone bitten. (I’m pretending I know you).
In this unlucky situation, it’s obviously fortunate she knew about the bite.

Can you share what general area you live in? I know around here rabies is very very rare. Was this at night or during the day and where (in the house or?). We have them here, and at times even IN the house!, and my only worry is they say you may never know you’ve been bitten.

Interesting about the 15 years!!! Thank you for sharing because my only source of this info was from that one interaction with the CDC.

[adssx]

NHS England: People in London urged to get RSV vaccine

Since 1 September, pregnant women and older adults aged 75 to 79 have been vaccinated as the NHS ramps up efforts to avoid a tripledemic of Covid, flu and RSV this winter.

[Bicep]

I know this won’t change any minds here, but this is a video of 2 phd’s talking about vaccines. One was a college professor, the other did his phd on vaccines. Both liberals and they talk about their politics, which I found to be very interesting. There are ways in which I am a liberal, when it comes to medicine I am a conservative:

Unsafe at Any Speed: Dr. Toby Rogers on DarkHorse

If nobody kills Trump and RFK gets in, then maybe studies will be done with bias in the other direction for a while. Interesting what happens in the next few years. Glad I’m still alive.