#1

In preparation for getting on a bunch of meds including rapa, I thought that perhaps I ought to get up to date on my vaccinations. This is based on the consideration that perhaps there are fewer variables in getting vaccinated and not having to deal with so many meds at the same time. Also, it seems that possibly, there may be some dementia protection associated with vaccinations.

I was planning on getting hepatitis B, update hepatitis A (las I had it was 2005), Tdap (13 years ago), pneumonia, covid, flu.

This study seems suggestive:

Here is a relevant table:

Table 3

Subgroup analysis of the association between vaccination and dementia risk.

Subgroups Studies HR (95%CI) P overall effect Heterogeneity (I 2, PH) Effects model
Total 17 0.65 (0.60, 0.71) <0.001 91.8%, <0.001 随机
Vaccine type
Influenza 9 0.74 (0.63, 0.87) <0.001 97.7%, <0.001 随机
Herpes zoster 3 0.69 (0.67, 0.72) <0.001 10.8%, 0.339 Fixed
Tdap† 3 0.69 (0.58, 0.82) <0.001 97.1%, <0.001 随机
Bacillus Calmette–Guerin 3 0.42 (0.17, 1.07) 0.069 91.5%, <0.001 随机
Pneumonia 2 0.68 (0.41, 1.13) 0.137 92.8%, <0.001 随机
Poliomyelitis 2 0.78 (0.44, 1.40) 0.406 73.6%, 0.052 随机
Other 1 0.78 (0.74, 0.81) <0.001 21.0%, 0.256 Fixed
Gender
Male 5 0.66 (0.58, 0.74) <0.001 56.8%, 0.055 随机
Female 5 0.67 (0.63, 0.72) <0.001 0.0%, 0.911 Fixed
年龄
<70 years 5 0.74 (0.66, 0.84) <0.001 72.6%, 0.001 随机
≥70 years 7 0.64 (0.57, 0.72) <0.001 94.6%, <0.001 随机
Dose ‡
1 vaccine 3 1.03 (0.98, 1.08) 0.229 6.9%, 0.342 Fixed
2-3 vaccine 3 0.87 (0.74, 1.02) 0.088 88.9%, <0.001 随机
≥4 vaccine 4 0.51 (0.32, 0.80) 0.003 98.7%, <0.001 随机
Dementia type
Alzheimer’s disease 10 0.63 (0.55, 0.72) <0.001 87.9%, <0.001 随机
Vascular dementia 1 0.60 (0.45, 0.80) <0.001 NA NA
Other dementia 1 0.69 (0.62, 0.75) <0.001 NA NA

HR, hazard risk; OS, overall survival; DFS, disease-free survival; NA, not applicable; Tdap: tetanus, diphtheria, pertussis.

†This analysis group included cohorts that reported receiving one or two of the Tdap vaccines.

As can be seen the hazard ratios are pretty strong. This is a metastudy, but seems a decent design.

I know the topic of vaccinations exercises some people and it can be a controversial topic, but I’m trying to approach it rationally, just follow the balance of evidence whereever it’ll take me. I’ve already had shingrix and multiple covid vaccinations (mostly Moderna) since they first became availabe, and was always able to tolerate them well (lucky?). I have not had covid that I know of, and I’ve been tested several times, not just home tests but before a colonoscopy and other procedures they demanded I get tested. Of course, I might have had covid at some point and simply not known about it, but if so, it was symptomless.

Do you think it makes sense to line up my vaccination ducks in a row before jumping on the rapa, empa, acarb, bempo, ezeti train?

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Paxlovid + rapamycin
#2

I recommend you read this paper below. There is some reasonable evidence that taking Rapamycin prior to vaccination will improve your vaccination response, so you might want to consider taking rapamycin for a few months prior to vaccination:

Related:

Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext

and

RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial

https://www.sciencedirect.com/science/article/pii/S246850112030002X

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#3

Thanks, RapAdmin, I did think about this famous Mannick study, which really in many ways is the guiding light for the rapa biohacking community at least when it comes to dosing regimens.

I thought about this, but I reasoned in the following way. Results in the study were very positive on the whole, with an immunity advantage for the rapa analogue. But I know for a fact, that I respond very well to vaccines in general, get good protection and never really suffer any difficulty. So there really is no downside to getting them as usual. Meanwhile, I don’t know how I would react to them after rapa. The promise is that I would react “better”. But that’s a gamble, and if I already react really well, that’s a bird in the hand versus two in the bush. If I had subpar results, then gambling on after rapa might be worth the gamble. Since I got a sure thing now, my incentive to gamble for better is pretty low, even if the risk of a worse outcome after rapa is probably pretty remote too. The sure “very good” beats the “possibly brilliant”. YMMV.

#4

These studies might suffer from a “healthy vaccinated effect”: people who get vaccinated tend to take care of their health more and to be wealthier. We don’t know (yet) if the association is causal. That’s why the Lancent Commission on Dementia Prevention 2024 did not include vaccination as a modifiable risk factor.

However, more recent studies are trying to reproduce natural experiments by looking at the introduction date of a vaccine in a given country and the dementia rate for people born before vs after this arbitrary date. Some vaccines still seem protective but the OR are smaller. See this thread: Vaccines for longevity - #25 by adssx

(worth merging these threads?)

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