#22

Another great AI is Claude from Anthropic

You can upload PDFs or other documents up to 15mb and chat about them. I actually find Claude to be “smarter” than any of the GPTs.

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#23

Thanks for sharing Claude, loved it. Also decoding Sinclair’s secrete :smiley: Is there another ingredient? His cocktail mentioned 6 chemical compounds.

#24

Claude seems to think that there are 6 listed cocktails in the paper and that there’s no indication in the paper that they’ve left out any ingredients from the recipes. Is it possible there is a separate cocktail that was not included in the paper at all? It seems that the ones in the paper are complete.

#25

I would always make sure to double check this. You can buy Forskolin on most health food site, it’s not a research chemical. I believe their were 5 different variations and not all of them were as efficacious.

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#26

This is the slippery thing about LLMs. They’re right a lot of the time but they sound right all of the time. And it can be really hard to pick out that 5% (or whatever %) that is incorrect among the correct stuff.

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#27

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I hope that helps.

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#28

Thanks Paul, so great to have a resident geek in AI :grinning:

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#29

If you are a billionaire, you can take the cocktails and ask a commercial mouse lab to test the cocktail (search term: in vivo DMPK). But I caution you: just because it helps tissue culture rejuvenate, it does not mean giving it to mice will work. For example, tissue culture requires daily changes of culture medium for nutrition, but if you drink the culture medium you will likely get sick; conversely, your favorite organic drink may benefit mice, but dumping the drink into the tissue culture will kill the cells.

But if you are really a billionaire, call up Jackson Lab or Charles River or any of the mouse companies, run the test of the best-performing cocktail with the least toxicity on mice, and see what happens.

I know physicians, not pharmaceutical companies, who are testing their favorite compounds on mice using commercial mouse labs, in their spare time.

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#30

My strategy is to follow closely the smartest persons in the field who also have enormous reach and resources and find out what they do personally. That’s all the validation to me. Peter Attia, Peter Thiel, Ray Kurzweil, and Larry Ellison are all incredibly smart (on Rapamycin). “Rapamycin is no a brainer” per Vinod Khosla. I am trying to chase down info on Hal Barron of Alto Lab if he is using it. It would be great if we can find out what all those chemists are on as there are many of them who live well above the 90s and are still incredibly lucid like Rudy Marcus (see the interview this yr). Also Bruce Ames and Charlie Munger. Most of them are in California.

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#31

Peter Diamandis is also interesting, with a slightly different rapa protocol (including 100 mg doxycycline), he also takes Leqvio, a siRNA.

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#32

Do you know why Losartan is on his list?

#33

Most likely bc of BP issues. Why else?

#34

but I am curious why Losartan, a 1st gen ARB instead of new one like telmisartan for instance

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#35

Can you talk more about this? I am very curious. What sorts of things do they test?

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#36

I have seen Lorsatan mentioned several times as a possible longevity intervention besides BP control (if I am not mistaken)…

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#37

If you have three hours, these are some of the smartest guys in the room.

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#38

Nah… I can’t. My friends will be very upset.

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#39

I’m more interested in Wolfram’s theory of everything Re: physics than whatever he has to say about things pertaining to life extension. The ruriard stuff is mind blowing though I can’t get my topologist friends to take a look and weigh in.

Having said that, it was his book “A New Kind of Science” that convinced me in my gut that aging is probably fundamentally the result of very simple processes, which could possibly be reverse engineered or at least slowed down if not stopped. Before that book I thought it was all pissing in the wind.

Taleb I’ve read with interest since I was 20, and he’s a very interesting thinker though somewhat unhinged.

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#40

A 747 left out in the elements falls apart in complicated ways because it’s a complicated machine, but the process of rusting is very, very simple.

We may end up with all kinds of diseases of aging that are exceedingly complicated and nearly impossible to cure individually, but if we can stop the “simple rusting” that might be more than enough.

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#41

A thought that probably owes its origin to reading Taleb over the years is that pulsed vs continuous dosage matters — not sure how or which is better but the body will make a distinction. Also I pulse most of my supplements based on a similar hunch. I put them on rotation on the intuition that it’s probably best to wheel them in and out of my system rather than having them always in me.

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