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#303
According to @John_Hemming 's theory that means they’re working and sleep disturbance should stop after a few days or weeks.
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Yes, if they are causing additional autophagy that is expected to raise issues with sleep.
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Nlo
#305
Thank you for this explanation, John. I have had sleep disturbances with rapa and wondered if this was a negative, signifying that I was in the category of people who would not have benefits from Rapamycin. Given your theory about UA sleep disturbances being a sign of autophagy, would you extend that same theory to sleep disturbances with Rapamycin?
If so, is this mostly conjecture or is there data to support this theory?
Third question, how do you explain the many people who immediately have great sleep and energy with Rapamycin? Do you think that they have less cellular debris to auto phagocytose? And did I understand that eventually people will regain their sleep while taking the UA gummies (and/or Rapamycin)? Sorry to pepper you with so many questions, but I’m very interested to learn.
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There was paper that linked autophagy to the disruption of circadian proteins. I have had a quick search, but not found it. I have probably posted it previously.
It appears that this is temporary. Sleep is quite a complex process which can be affected in many different ways.
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Why would you think they increase autophagy? Have you seen any studies indicating that urolithin A can increase autophagy in vivo?
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Not sure what the “they” is here.
There was a paper (and I don’t mind trying to find it, but it is not that easy to find) which said autophagy caused the disruption of circadian proteins
I have done a bit of experimentation with high dose UA which seemed pretty futile unlike high dose rapamycin.
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Sorry for the confusion. “They” was not the best word, I should have said “it”. I was referring to Urolithin A since I took your comments above as if you think that increases autophagy and am wondering why.
Regarding autophagy disrupting circadian proteins, I’m not questioning that as being true.
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UA may help, but it is not on my list of autophagy agonists. I tried quite a high dose earlier this year and it did not seem to move the needle. Its one of those things that may be helpful, but not that useful.
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