SNK
#182
Why would drinking with a straw be any different than drinking it directly from a glass? Don’t both methods take it to the same place. Never heard of this…LOL
AnUser
#183
It’s to protecc the teeth.
2 Likes
SNK
#184
Ah makes sense. Used to eat a lot of pomegranates (not juice) in my prior life and you are right it does stain the teeth, but if i recall correctly it doesn’t last too long.
Neo
#185
1 Like
FYI. I’m not paying full retail price for this stuff. I’m only using Urolithin A because I can get discounted pricing.
I started taking UA about 2 months ago in what I call my MAX-5 combo supplement.
Doing this as a 6 month experiment. Only problem is the result won’t be UA specific as MAX-5 has 5 compounds in it at the most currently understood clinically effective doses. I have been taking 800mg of NMN for about 18 months and have seen significant telomere length increases over 2 tests so I “kind of” have a baseline for that one. The other 4 compounds will be new to my program.
In September we will be doing our 5th Trudiagnostic test. If the results are “interesting” we will probably offer this as a product.
The Max 5 daily dose includes;
Spermidine 98% 25.0 mg
Ergothionene 99% 20.0 mg
Urolithin A 97% 500.0 mg
Ca-AKG 100% 800.0 mg
NMN 99.5% 800.0 mg
To duplicate this at retail prices (adjusted for dose comparison) it would cost $500 to $600 per month.
Our target price will be $200 per month.
1 Like
SNK
#188
With exception of Ergothionene which i have never tried I have done all of the rest, and I can attest I felt absolutely zero effects good or bad from any of them. Perhaps NMN could have been barely a mood lifter, but not enough to notice. I know many, many and many other combination substances/supps that would be under $200 per month and get much better results. To each their own, but I would say $200/Mo is a bit steep for me, especially given that I did not notice any benefits.
On another note, I placed an order for a bottle of Agmatine Sulfate since I’ve heard few people rave about it for mood elevation and blood circulation. Would be interesting to know if any on these boards have used Agmatine and how do you feel about. Haven’t heard anyone in here mentioning it, but maybe i missed it.
1 Like
Neo
#189
Was this with LifeLength or how did you measure?
www.trudiagnostic.com 4 tests over 3 years. I’ve posted my results and my wifes results here, somewhere 
2 Likes
Going by how I “feel” is bit too subjective for me personally. I typically look for some change in my measured results.
Dose is important, for example, less than 15mg of Spermidine showed no effect in several studies and yet the most “popular” brand only provides 5mg.
Similar to the glycine + NAC combination, doses below the ones used in the successful (measurable results) studies showed minimal benefit.
Dose is one of those important things that is often ignored by many providers of dietary supplements because its too “expensive” and they would rather sell what fits in a budget as opposed to selling what actually works.
5 Likes
SNK
#194
Huge LOL. I’m planning on creating my own supplement pretty soon, it will be life changing 
1 Like
SNK
#195
Actually, you bring up an important point. I also have seen big differences with certain supplements at different doses.
1 Like
Neo
#196
Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
RESULTS
Long-term UA treatment significantly improved learning, memory, and olfactory function in different AD transgenic mice. UA also reduced amyloid beta (Aβ) and tau pathologies and enhanced long-term potentiation. UA induced mitophagy via increasing lysosomal functions. UA improved cellular lysosomal function and normalized lysosomal cathepsins, primarily cathepsin Z, to restore lysosomal function in AD, indicating the critical role of cathepsins in UA-induced therapeutic effects on AD.
CONCLUSIONS
Our study highlights the importance of lysosomal dysfunction in AD etiology and points to the high translational potential of UA.
Highlights
- Long-term urolithin A (UA) treatment improved learning, memory, and olfactory function in Alzheimer’s disease (AD) mice.
- UA restored lysosomal functions in part by regulating cathepsin Z (Ctsz) protein.
- UA modulates immune responses and AD-specific pathophysiological pathways.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13847
3 Likes
adssx
#197
In mice 
Still interesting. The effects were seen over the short term (2 months) and long term (12 months).
Hopefully Urolithin A will extend C. Elegans lifespan in the MMC…
2 Likes
When you do create your own supplement, I look forward to seeing the test results
Here are some results from a little evaluation I conducted with 4 people using the first formula I developed. I supplied the product, they paid for their own testing with a company I trust. www.trudiagnostic.com If anyone is interested in doing this, let me know, I do have a discount code for the test for our participants.
Combilytics_Corp_Product_Evaluation_Protocol_TRU.pdf (149.7 KB)
1 Like
I started UA 3 months ago but I confounded the process with 4 other compounds that show promise. I will be doing our 9 month Trudiagnostic test in September to see if there have been any changes. Yes I will post them, good or bad
4 Likes
Good video today on Modern Healthspan with bits of three different interviews addressing mitochondria. Right near the end, at 26:40, the guest answers the question of which interventions will encourage mitophagy:
Went on Amazon, picked four of the cheap urolithin a brands at random and two of them said they were third party tested.
4 Likes
Very interesting video. Thanks for posting. Regarding Urolithin A, I understand there is only 1 raw material supplier to the brands selling these supplements in the USA, and maybe elsewhere. Make sure you are getting the real stuff.
