It’s mentioned in the phase 2 report on reta https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
Reductions in the low-density lipoprotein cholesterol level of approximately 20% with retatrutide may reflect the effects of glucagon agonism on PCSK9 (proprotein convertase subtilisin/kexin type 9) degradation
It would be interesting to see what dexa scan shows.
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Small Caveat, tirzepatide results seem to be based on obesity trials, white retatrutide ones are based on t2d:
However, it is worth mentioning that the only data available on the body composition of Retatrutide were based on an RCT for individuals with T2D and not from the most recent phase 2 RCT specifically for obesity (which lacked data on body composition)
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Davin8r
#64
Yes, for sure. Very preliminary data, but I was just surprised by the fact that it directly contradicts what so many influencers are claiming. I certainly want retatrutide to be maximally effective for body composition, and I hope the phase 3 trials bear this out.
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Agreed. And the various GLP1 forums seem to indicate its superiorityik that and other aspects. I certainly have noticed many people either buying more retatrutide or stacking it with tirzepatide lately. I strongly suspect retatrutide is superior in many ways, and will soon consider acquiring some in the future.
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Influencers want to shill something new and exciting that brings them clicks and potentially allow them to shill gray market products.
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One of several papers that show that tirzepatide doesn’t induce weight loss just by restricting calories
https://diabetesjournals.org/diabetes/article/72/Supplement_1/127-OR/149096/127-OR-The-Effect-of-Tirzepatide-during-Weight
We hypothesized that tirzepatide (TZP) causes body weight loss by reducing food intake and, according to pre-clinical studies, decreasing metabolic adaptation during weight loss. In a randomized blinded clinical trial in people with obesity (PWO) undergoing caloric restriction, we investigated the effect of TZP vs Placebo (PBO) on energy metabolism after targeting a 10% (±2%) weight loss. In this 18wk phase 1 study, 55 PWO, were randomized (1:1) to TZP 15 mg or PBO (mean baseline body weight 102.5 vs 103.1 kg, respectively). The primary objective was to investigate the change from baseline in sleeping metabolic rate (SMR) measured by whole-room indirect calorimetry. Secondary measures were changes in 24-hr sedentary energy expenditure, 24-hr respiratory quotient (RQ), sleeping RQ, substrate utilization, body composition (BC) and food intake. TZP caused greater weight loss than PBO (-16.7 kg vs -8.3 kg; p<0.001). The decreases in SMR and 24-hr energy expenditure were not different between groups after adjusting for changes in body weight and BC. However, TZP significantly reduced 24-hr RQ and sleeping RQ compared to PBO; thus, significantly increasing fat oxidation while decreasing carbohydrate and protein oxidation rates. TZP also significantly reduced food intake. Overall, TZP did not affect metabolic adaptation but significantly increased fat oxidation.
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Not just by decreasing food intake, no. But decreased food intake is a component of weight loss with this drug. Furthermore, if you look at the data in that table, the effect of decreased calories is huge, -59 cal for placebo, and -915 cal in the intervention. Wow. Food restriction ftw.
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Most of the GLP-1R’s stimulate brown fat, which may be where this increased fat oxidation is coming from. This has been understood for over 10 years.
This increase in thermogenisis also appears to be enhanced as more “G” is added GLP1 + GIP (Tz) and with Reta the addition of GCGR
On top of that it is also understood that GLP1-R’s increases the production of brown fat. More brown allows for more thermogenisis.
GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
https://diabetesjournals.org/diabetes/article/63/10/3346/17388/GLP-1-Agonism-Stimulates-Brown-Adipose-Tissue
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Seemingly me using tirzepatide with atorvastatin has been causing major myalga-related side effects. I have stopped my statin for the time being and will consider using pitavastatin at 1-4mg after a few months.
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AnUser
#71
I don’t know the timeline for myalgia related side effects but it might even be 8-10 months on its own iirc. Good that you stopped, that can turn nasty maybe into rhabdo.
You might be intolerant to all statins, or maybe there is one that works in combo with ezetimibe and the other drugs.
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I thought atorvastatin was doing well since I never had muscle pain before but then it came all at once, even with pain at my sides so I instantly stopped and restarted empa for additional kidney protection. I will probably try 1mg pitavastatin to begin with due to the following case report:
High Tolerability of Pitavastatin Therapy: A Case Report of Comparison with other Statins - PubMed
If that doesn’t work, I’ll probably bite the bullet and start bempedoic acid.
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I have tried retatrutide twice from the same company. I didn’t notice any positive results in fact l think it was counter productive for me. I was using terzepatide which makes me satiated much faster.
I am not sure if the stuff l received was real, denatured or if retatrutide doesn’t work for me.
When you reconstitute your retatrutide is cloudy?
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Not cloudy…
I have seen some peptides become cloudy when too much air is “injected” in the reconstitution process. I’ve done that when I’m in a hurry. So I’m careful when I reconstitute.
If it’s always cloudy, regardless of the care taken in reconstitution, I’d be concerned.
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Many thanks. If l try it again, l will go with a different company.
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Davin8r
#76
Also keep in mind that for the vast majority of anectodal reports from retatrutide experimenters, it’s not as good at suppressing appetite compared to tirzepatide/semaglutide but still works just as well (if not even better) for weight loss. Having a cloudy solution after reconstitution is highly suspicious for contamination IMO.
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cl-user
#77
I had once a Thymosin Alpha 1 vial that was cloudy. It could be air as mentioned by @Steve_Combi but in insight I think it’s more probably a potential issue with the bacteriostatic water as it stayed cloudy for the 5 days. I was out of my usual bacteriostatic water so I got a bottle from amazon and it’s the only time I got a cloudy peptide. I’ve never had any issue with that bacteriostatic water though.
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I have heard this too and used a fair number of peptides in the past and have not noticed them being cloudy. A lot of people here and elsewhere speak highly of retatrutide.
I would like to try a “real” potentially uncontaminated retatrutide before l call it though.
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Cloudy can be a sign of protein aggregation. Besides eliminating the efficacy of the drug, you really don’t want to be injecting yourself with clumped proteins. Some protein aggregation is always occurring, but if it gets to the point of being visible by the naked eye, it’s really bad.
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