His only support given for his statements to that effect in his 2021 paper is the exact same National Health and Nutrition Examination Surveys data that was used for the article that started this thread.
I will link his study at the bottom.
In his IF section of fasting in humans he literally lists a long string of all the positive marker changes from these fasting methodology. Study after study. Basically every major marker for cardio, hepatic panceratic health improved significantly. Yet he then under negativescan o ly list 2 one related to the breakfast and all cause mortality. The other gall stones in women . Guess what both thosetwo references havein common? They are both based on epidemiological research and both use the exact same survey data source of the National Health and Nutrition Examination Survey.
He then makes the rather perpoterous statement that a 12 hr fast or time restricted feeding TRF is safest. The issue with that is its basically the standard feeding window of everday population. 2 hrs on each side of a 8 hoursleep cycle is not restricted window its dalled bedtime and sleep. He does conclude that for those who are overweight have metabolic disfunction etc the 16/8 TRF IF is fine. Well thats means its good for at least 75% of tge USA popu,lation.
How he can settle that a diet that improves allmmetabolic markersin studies in length from a few weeks to years somhow then greatly increases risk of CVD and all ause mortality is simply preposterous and flies in the face of everythung we know from real world and research results. IMO his comments are flawed and I think given his knowledge he knows his support references are extremely weak at best. Nonsensical
Other than those specific comments the paper I felt was well written and of good quality.
[Nat Aging. 2021 Jan; 1(1): 47–59.
Published online 2021 Jan 14. doi: 10.1038/s43587-020-00013-3
PMCID: PMC8932957
NIHMSID: NIHMS1723531
PMID: 35310455
Intermittent and periodic fasting, longevity and disease
Valter D. Longo,1,2,
Maira Di Tano,2 Mark P. Mattson,3 and Novella Guidi1
Author information Copyright and License information PMC Disclaimer](Intermittent and periodic fasting, longevity and disease - PMC)
The two referenced papers supporting his stztement about breakfast and women gall stones
Association of Skipping Breakfast With Cardiovascular and All-Cause Mortality
A prospective study of hospitalization with gallstone disease among women: role of dietary factors, fasting period, and dieting.
One thing I know about gall bladder gall stones from dieting is the root cause is almost always a diet with low fat and usually low calories for extended period. Gall bladder bile acid not used concetrates in the gall bladder leading to stone formation and inflammation. Bile releae is stimu,ated by fat ingestion entering the small intestine. After a periodof very low fat low cal diet when a high fat meal is eaten you get the pain from the blockage and inflammation. Doctors then tells patients to eat low fat but this only temporarily reduces the discomfort and actually exaserbates the issue forming and enlarrging the “stones”. Again this is from diet induced gall stone not other pathologies. As this survey data was from the 1980s/90 it was mist certainly low fat high carb low cal. Also will point out that intermittent fasting was not even a diet protocol back then. Nor was the rampant metabolic diease we have today but is in no small part from those failed health and dietary policies back then. Transfats crisco margine, white rice, pasta and very low fat and all saturated fats are evil evil evil. Those were the mid 80s to early 90s Fat free everything
