There seems to be a new category lately. The smart person (out of their personal depth) with a staff of “researchers”. Attia, Rhonda Patrick, Huberman. From being burned I don’t have pure faith in any of them or anyone else. If an influencer deserves it in my opinion, I trust but verify as best I can. And, always, doing nothing is a good option. I’m thinking about a lot of things that I wish I knew what to do.
At the top of the pyramid right now is Kaeberlein. He seems to be a rare combination of fair mindedness, a very good judge of data, and is unbiased, as far as I can tell.
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I have listened to brad stanfield’s video. He advocates for very low dose melatonin taken 1-2 hours before sleep. He considers 10mg to be a high dose. He is unaware of doses of 60,200,400 that are available OTC.
Andrew huberman is quoted warning that melatonin has puberty delaying effects. Also in children melatonin is releaaed all day.
I have glanced at the referenced papers. None consider the fact that melatonin is injected into the CSF. They also dont look at the use of melatonin for sleep extension.
He does however take melatonin himself.
As people know i suggest taking melatonin during the night or time released.
https://twitter.com/sinanmellaart/status/1695891833904140288
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LaraPo
#33
My 3 mg dose is huge in comparison with his. Will reduce mine or even try to sleep without it. Glycine works pretty well too. It’s a pity there’s so much contradictory information almost about everything, not only melatonin. It makes it difficult to make an educated decision, no matter how much you read.
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Pure, unadulterated, YouTube clickbait aimed at gathering more subscribers, hence more fame and fortune.
If it wasn’t to change our minds, what was the point?
(And if you don’t like what I say, don’t listen!)
Apparently, Dr. Stanfield didn’t bother to read this.
Dr. Brad Stanfield apparently had nothing better to do than to resurrect an eight-month-old YouTube video in order to garner some viewers in hopes that they will buy some of his promoted supplements.
I haven’t looked at all of his videos, but at least his latest videos don’t carry a similar warning. They should.
Melatonin is IMO one of the safer supplements out there and one of the ones likely to do the most good.
Approximately 71 million adults in America are taking melatonin.
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Apologies, I just found the post on eye health.
One of the arguments against Melatonin is that Golden Hamsters who take a quantity of it (I am not sure how much) have smaller testes.
This could be part of its anti-puberty effects,
However, it is available off the shelf in France. It is not even kept behind the counter like medicines like Ibuprofen.
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LaraPo
#38
If it has anti-puberty effect, does it mean that it delays/puts on hold aging? What are your thoughts? Yesterday skipped melatonin before going to bed and slept exactly the same 7 hours as with melatonin (same deep, rem and core).
Its merits from an antiaging perspective lie in the mitochondria. Is there a risk of reversing puberty? Possibly with enough, it may be that more ros are needed to go through puberty. In the end, however, too much ros is a problem. I dont take melatonin to get to sleep. I take it for sleep maintenance or after waking for the side effects.
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AnUser
#40
Has there been any clinical trials showing proof of safety of ultra high dose melatonin?
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I have looked but found none. Those of us who take high-dose melatonin are just self-experimenters. The same can be said for those taking rapamycin and some other supplements and drugs being tried by members of the forum.
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Here’s my talk with Dr Scott Grafton on Physical Intelligence and Healthy Aging. The TLDR is don’t focus on exercise (treadmill, stationary bike, weight machines); do a variety of physical activities that engage the brain. And don’t wait too long to get started.
Physical Intelligence
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Research Paper:
Influence of Strenuous Physical Activity and Cardiorespiratory Fitness on Age-Related Differences in Brain Activations During Varieties of Cognitive Control,
Paulina Skolasinska et al,
Neuroscience (2023). DOI: 10.1016/j.neuroscience.2023.04.007
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Dr. Fredericks explained why exercise is important for overall health, including preventing dementia:
- Exercise improves cardiovascular health, and we know that better cardiovascular health — healthy blood pressure and cholesterol, for example — are linked to a lower risk of dementia.
- Exercise reduces the risk of insulin resistance and, down the line, diabetes, and diabetes is linked to higher dementia risk.
- Exercise reduces overall inflammation in the body, which also helps reduce dementia risk.
Dr. Liron Sinvani, director of geriatric hospitalist services at Northwell Health, noted that there are shared risk factors between a sedentary lifestyle and dementia.
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Keep that blood pressure low!
Key Points
Question Are blood pressure (BP) and treatment for hypertension in late life associated with dementia risk?
Findings In this meta-analysis including individual participant data from 34 519 community dwelling older adults in 17 studies, untreated hypertension was associated with a greater risk of dementia compared with treated hypertension, and this association was not modified by age. Participants with treated hypertension had no greater dementia risk compared with healthy controls, and baseline BP did not moderate the reduced dementia risk in participants with treated hypertension.
Meaning The findings indicate that ongoing antihypertensive therapy throughout late life is an important part of dementia prevention.
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My mother has high BP. What have people found to be the best ways to lower it?
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Goran
#47
For me, nothing comes close to Psyllium Husk. Works wonders.
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Good idea, but she refuses psyllium Husk. I’ve tried that already. The bag just sits on the counter and rots. However I wish she would try it. She’s a pill woman.
You can either buy pills and put psyllium Husk in them or get pills of psyllium Husk. It happen I buy it in capsule form. I do, however, eat over 25g of chia seeds on days when I am not fasting.
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Does she eat fruit? Bananas and other fruits are known to lower blood pressure.
Also, I have a supplement that I occasionally use: Potassium BHB Salts, Exogenous Ketone Supplement, available from Amazon. I was using this instead of the sodium or magnesium form because I was already taking a magnesium supplement and didn’t want any more sodium in my diet. This is one of the most hygroscopic substances I have ever encountered. Mix 1 tablespoon in an ounce or more of water and drink it. It almost instantly lowers blood pressure because of the potassium content.
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