For those of us on TRT, one side benefit might be increased estrogen, providing it does not have unwanted side effects like man boobs. Some docs will prescribe aromatase inhibitors to avoid side effects and other docs, including Attia, do not find it necessary if weekly testosterone dosage mimics endogenous testosterone production of a young man and does not reach a supraphysiologic level. Subcutaneous rather than intramuscular injection is also supposed to result in a slower release of T and reduce aromatization.
I’m currently on a 200 mg weekly intramuscular injection and haven’t seen a spike in estradiol blood values.
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On the broadest blood panel I do I have unusually low Oestradiol and I have no idea what that means. This is 17β-Estradiol which AIUI is a form of Estrogen.
However, I still dont know what causes this or what it signifies.
Oestradiol is another name for estradiol, which is one of three forms of estrogen and commonly tested for. If you are taking an aromatase inhibitor, you might want to discuss dialing that back with your doctor. If you’re not taking anything, I don’t know how to interpret the result.
I am taking lots of things, but the only real prescription med is Rapamycin. (I have Melatonin and 25OHD that are RX in the UK).
I have just looked at the history of results from this Lab and it has bounced around a lot. I keep detailed records as to interventions and I may try to identify if there is any correlation between it and interventions.
Sometimes there are, but sometimes it is hard to identify anything.
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It certainly seems a safer alternative than 17-α Estradiol.
And, of course, is available from India in tablet form for a very reasonable price, less than 10 cents a tablet.
The question is what dosage is best for life extension.
I wonder how it would make men feel? Other estrogen-effecting compounds such as Clomid can have negative psychological effects in men.
I found a short YouTube video about estriol stating it is the safer form.
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India to the rescue again! Nice find. The Life Extension site has similar positive view of estriol, but both it and this video are focused on women.
Can anyone with better understanding of pathways involved with 16-a and 17-a speak to there comparative impact on secondary sex characteristics in men?
And for the women site, Matt is puzzled by the negative longevity impact of estriol in the ITP’s female mice, since in a recent analysis of UK biobank data shows a positive longevity association with estriol, as well as other forms of estrogen in women, who are almost exclusively estriol’s users.
He thinks it may be an artifact associated with the type of mouse used in the study.
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I just yesterday saw someone mention AKG in a FB group, and I was thinking “hmmm I’ve never heard of it, I should look into it.” But now I don’t have to!
#Winning
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I just asked my cardiologist about SGLT2i (due in large part to what @adssx had been saying about Cana in other threads) and he prescribed 10mg daily.
The problem now is that CVS is going to charge me $200 for 90 pills. Ouch. I’m definitely going to get some quotes from India Mart.
EDIT: I asked him about SGLT2i generally, not Cana specifically, and Jardiance (empagliflozin) is what he recommended for me, so that’s where I’ll start.
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AnUser
#51
Why does the ITP study write 16α-hydroxyestriol instead of 16α-hydroxyestradiol? Only two matches on Google Scholar for the former. Did they misspell it?
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I am not sure the ITP results on AKG are the whole story. I am switching AKG in and out of my stack. I think there are some effects, but I am not entirely sure what they are.
I think the effects, however, require a metabolically relevant quantity (not just a few million femtograms)
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adssx
#53
Just in case: although I think SGLT2i are a wonderful class of drugs (to protect the heart, kidney and liver at least), but among this class I don’t know (and no one knows) if canagliflozin is the best one. It’s the only one that has been tested by the ITP though.
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AnUser
#54
Do you mean 100 mg of Cana?
Actually it’s not Cana at all. It is empagliflozin 10 mg. I came out of the conversation mistakenly thinking Jardiance was Cana, but it’s empa. My bad!
The dosage is low because I’m not diabetic or even pre-diabetic, very good a1c and HOMA IR.
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AnUser
#56
The dose-response between 10 mg empagliflozin and 25 mg isn’t that different, and you can use a pill cutter on the 25 mg.
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Do I want to do that because the 25mg is a lot cheaper?
AnUser
#58
On Amazon Pharmacy and offshore it is the same price for both doses so you save 50%. I didn’t know a generic version isn’t for sale in the USA.
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LukeMV
#59
I agree @约瑟夫_拉维尔
I think it’s a terrible idea to use an aromatase inhibitor to block estrogen conversion on TRT. Any clinic who tries to get men to do this should be avoided in my opinion.
The normal estradiol range in men was created for men who aren’t on TRT. AI’s have more side effects than slightly high estrogen on TRT. The fact these two forms of estradiol tested in the ITP improve lifespan only make me feel more strongly about this.
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According to some studies, estriol has been found to potentially be safer than 17-α Estradiol.
“The bioidentical hormone debate: are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?”
"Estriol’s effect on cardiac risk factors has also been somewhat equivocal; however, unlike conventional estrogen prescriptions, it does not seem to contribute to hypertension.
https://sci-hub.se/10.3810/pgm.2009.01.1949
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This source likely refers to 17β-estradiol, generally known as estradiol and used in female HRT. It has 100% binding affinity with the primary estrogen receptor, hense its powerfull and feminizing effects. In rat models, 17a-estradiol has only a 4.8% binding affinity and estriol has 10%.
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