#27

It is in “ng/mL”, with 30-100 being the range

#28

There is quite a bit of an interplay between Vitamin D levels and autoimmune issues. You may wish to discuss with your medics whether it is worth trying to hold a higher 25OHD level more towards the top end of the range.

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#29

thank you, I am leaning this way… that precluded me from doing so is the emerging Vti D controversy, which I am not even qualified to discuss, very complex. But you right - the association between low vit D levels and autoimmunity is strong!

#30

I just read your new comment where you suggest reading about your experience another “outlier” - how did I miss that while researching on this site!? Problem is that it disappeared into the ether before I could click on the link to your side-effects post. I searched and saw some of it, but would appreciate if you re-posted the link so I could read it from the beginning… thnx in advance sol :-))

#31

The Vitamin D Controversy should be a more subtle debate about the best 25OHD serum levels to target. Realistically this will vary from person to person, but is it is an important issue. There are levels that are too low and there are levels that are too high. It is hard to work out what these are.

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#32

I didn’t say all that much–it would be a much longer post to detail the specifics of my unusual biochemistry, and some of the details are not particularly relevant. Here it is: my first post.

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#34

Or even 1/2 mg of rapa.

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#35

try taking genuine sirolimus pills, Pfizer’s Rapamune

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#37

@Kira_Miftari Sorry to hear your story but thanks for finding this forum and telling. Never know who else might benefit.

I’m sure you tried this common protocol; LDN, low dose naltrexone, 5mg dose daily often at night. It also calms the immune system. Lots of auto-immune sufferers find relief after a months use…

Best of luck, curt

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#38

This product contains alleged natural rapalogs (mTOR inhibitors): Meriva (curcuminoids bound to phospholipids), green tea extract, white willow bark (containing salicin), and a couple other things.

I have no idea if the ingredients actually are mTOR inhibitors or how safe they would be for you to ingest. You could look into it. Wishing you the best.

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#39

This is the problem I have with speculative supplement companies. Calling this Rapalog is deceiving. Looking at the ingredient list, Resveratrol, Green tea extract and fisetin for example is not Mtor inhibitors as far as I know. They are all unproven in the longevity field. This is speculative crap.
I hate companies like this, they just make this field less believable and serious.

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#40

YEs, thank you - that is my current thinking, if I ever gather the balls to risk it… In your opinion, any concerns for breaking the protective coating that is supposedly important for its safe delivery?

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#41

Thank you for the suggestion… I thought about it initially, but I am scared to do it bcs it is more than likely that this is just my reaction to the Rapamycin molecule… Also, I checked: the 30 pills of Sirilimus 2 mg cost me $210 with discount in US pharmacy, the brand Rapamune1 mg will cost me over $1.000

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#42

Thank you :-)) I did look at the botanical analogues, and it turns out I am already using 2 of those - Green Tea and Ashwaghanda… better than nothing!
( I may add Ginseng bcs I have been interested in it for a while now, its just hard to find good sources of a 6 year Korean Ginseng with no additives …)

#43

I agree, I noticed the Fisetin as well - I am sure they added it bcs it is a very popular supplement that may or may not stimulate cell senescence… the research is contradictory. But it doesn’t belong in this formula.

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#44

Try 1/4 of a mg, sublingual to see if you can avoid the stomach issue. If that works with minimal distress stay with that dose and shorten the days to 6, then 5, then 4 between doses.
There are injectable versions I’ve read about as well. Try that first!

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#45

Kira, I am cutting and pasting part of a chapter I wrote on aging re AMPK activators. There are a lot of them.

Berberine is one of the compounds known to activate AMPK. Berberine extract is available as an extract supplement as well as whole plant supplements.

Jiaogulan, an herb from Chinese medicine has a reputation as the longevity herb. It provides potent antioxidant protection, and also activates AMPK, like Berberine does, and inhibits proliferative activities. The literature is replete with evidence this one is anti-cancer. Jiaogulan is apparently an easy to grow vine, the leaves of which are used for tea. Easily obtained as a supplement.

Ginseng-panax type, Ginsenosides. A number of ginsenosides have been reported to activate AMPK, resulting in decreased liver triglyceride and cholesterol levels, and the inhibition of fat production and liver glucose production. As a supplement, this should be taken in the morning as it is known to induce insomnia. I find that to be true, and in the morning it boosts all day energy for me.

There are many more AMPK activators. This mechanism probably accounts for much of the touted health benefits of many things in general acceptance as good for us. Here is a partial list. I do not think taking/getting all of them is feasible, cost effective or even productive, but we have many choices.

• Ashwagandha—Withania somnifera, Indian Ginseng—More to come on this
• Resveratrol from red grapes—take with some fat for absorption
• Quercetin from many plants including fruits, vegetables, and grains.
• EGCG from green tea –Epigallocatechin gallate, is a polyphenol
• Curcumin from turmeric
• Anthocyanins found in blueberries, bilberries, grape seed extract and pine bark extract
• Nicotine (only in fat cells) and intervenes in the anti-inflammatory effect of nicotine. Why smokers stay thin.
• Bitter Melon (Cucurbitane)
• Carnitine
• Glucosamine
• Fish Oil/Omega 3’s
• Fisetin
• Zinc
• Cinnamon
• Astragalus root–used for centuries in traditional Chinese medicine
• Reishi–mushrooms
• Apple Cider Vinegar /Acetic acid, Pomegranate vinegar
• Allontoin-found in comfrey, aloe vera, sugar beets and yams. The natural product most like Metformin (see below)

Research indicates that more benefit is reached when several of these are used together.

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#46

Thank you for your suggestion, Greg. I am definitely considering this route - as soon as I gather the proverbial balls to take it again… Thoughts on breaking the all-important protective coating?

#47

This is great, thank you so much Ellie! After my fiasco, I researched the botanical route as well - after all, Rapa is extracted from a natural source, just like Metformin. I was glad to learn that I am already taking 2 of the items that are possibly weak analogues of the aforementioned drugs - I drink strong Green Tea every AM, and take Ashwaghanda with it. Just started to add Berberine to this mixer dn waiting for Reisho power, too… I think this is already more than normal ppl would ever take, lol
Contemplating Ginseng - that is a whole different rabbit hole. Not easy to find a quality 6 year Korean Ginseng. As far as Gynostemma – which resemles Ginseng in its beneficial saponin content - it is much easier to acquire and absolutely delicious as a tea. Wonderful list!

#48

I recommend you read up here… I have not looked into the issue closely, each of the manufacturers (Pfizer rapamune, the generic vendors like Biocon and Zydus, etc.) use a different approach and technology, so you’d likely need to read up, and ideally do blood testing after dosing to see if its getting through the gut acids.

Here: Rapamycin and NanoCrystal Formulations

Here: How to get a Rapamycin (sirolimus) Blood Level Test

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