#15

their category of IF/CR seems poorly defined. Calorie restriction, without going too far, is the most sure way to increase maximum lifespan.

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#16

What are people’s thoughts on HBOT?

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#17
  • exercise - while it clearly improves healthspan and health state and probably decreases mortality, does not generally have support in the literature extending lifespan or longevity, so that one might actually be as we’d expect based on other geoscience literature
#18

@Neo I think HBOT is a double edged sword. Extra oxygen sounds helpful when there is poor blood / oxygen circulation and a persistent infection or a poorly healing wound. But extra oxygen for the heck of it sounds dangerous from an oxidation point of view. What good could come of it? I’d rather go for low oxygen training.

Am I missing something?

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#19

@约瑟夫_拉维尔 Yeah, I’ve been wary about it, but it keeps coming up in many contexts, so thought might be worth some discussion with any people who have been thinking about it.

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#20

Its interesting, but most of the longevity / telomerase research and HBOT seems to be coming out of a single lab in Israel, where they also commercialize it (so not exactly unbiased in their research). We’ve discussed it in the past a bit here: Hyperbaric Oxygen Therapy

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#21

HBOT is a HIF 1 alpha thing

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#22

From a longevity scientist at the Buck Institute on Aging:

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Source: x.com

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#23

Apart from the high oxygen under pressure state of HBOT that assists damaged tissue to heal, HBOT is a stress activity for the brain and I believe that is where the magic comes in: when in the chamber,you go from a high oxygen state to a relatively low oxygen state when the 100% oxygen flow is switched off for 5 minutes. This I believe puts a strain on the hypothalamus of the brain which monitors things like blood oxygen concentration and it is the stress of this relative low-oxygen state that probably drives healing processes and stem cell activation.
I believe this is in keeping with other hypothalamic stresses like fasting, sauna, ice bath and high intensity exercise (low oxygen state).
This all still needs to be proven but certainly in HBOT research there is evidence of sirtuin activation in the hypothalamus that is suggestive that it is the hypothalamus that drives the repair.

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#24

HBOT is one of the therapies that causes a drop in partial pressure of oxygen from a steady state to a lower state. This does not have to be accompanied by hyperbaric pressures (greater than atmospheric pressures).

It stimulates the HIF 1 alpha response.

It may do other things. Hyperoxia over a period of time can be quite harmful depending upon how high and how long.

I did an analysis on this

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#25

are we back to metformin for non diabetes users? I thought Stanfield and the community wasn’t in support

#26

The section of this podcast where they discuss epigenetic measures of aging (bioclocks) is valuable and points to why this paper (mentioned in the first post) is really unhelpful at this time:

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#27

GOODHART’S LAW: When a measure becomes a target, it ceases to be a good measure.
Biomarkers are easily gamed by pharma treatments that change the # at the expense of hidden risks, e.g. Optimizing:
HbA1c
Hypertension
Cholesterol
Testosterone
Schmokhstsakirfingintfin, etc.

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#28

Plus random fluctuations in individual physiology and testing imprecision can lead a person to chase their tail in an effort to “optimize”. …chasing their shadow.

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#29

I find it incredibly interesting that in Dr. Salmons experiment with marmosets and Rapamycin, the marmoset median lifespan increased 15% on Rapamycin. However, Steve Horvath tested the epigenetic ages between the control and treated groups and found no difference.

This implies that Rapamycin may not change the epigenetic age although it increases lifespan.

Therefore epigenetic age tests don’t seem useful for determining lifespan if a 15% increase in lifespan doesn’t register on them.

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#30

The epigenetic testing has a number of issues. I am not persuaded it provides actionable information.

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#31

Agreed about epigenetic tests. This was cristslized for me in the latest Attia roundtable : if I compare the results of a complete metabolic panel with an epigenetic test, which one is more actionable? At least from a clinical POV, these tests are like setting money on fire.

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#32

These clocks are all for the most part useless. Give it up gang.

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#33

The people on the leaderboard of Rejuvenation Olympics avoiding taking the tests on bad days is all I need to know about the validity of the current tests.

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#34

DNA methylation is just one measure of epigenetic age, and there’s no reason to think it’s the ‘best’ one. Even if rapamycin doesn’t appreciably change the dynamics of DNA methylation (still an assumption, as this might only be the case in blood, for example), it might alter epigenetic age according to some other measure (e.g histone modifications, occupancy of nucleosomes or transcription factors, how ‘open’ certain regions of chromatin are, etc).

That said, this is still an area of basic research and acting like the consumer DNA methylation tests have clinical validity is ridiculous.

1 Like