#42

Right, these are just individual reports. I was just struck by the opposite and in both cases very strong interactions with lithium vs telmi and empa.

1 Like
#43

OK, scratch that hypothesis! What about telmi raising levels of lithium not from supplements but dietary lithium? Of course that would not account for the dapa mood elevation while eliminating lithium. So, still a mystery.

1 Like
#44

I think telmisartan only doubles lithium. That’s not enough to reach anything significant. In the dozens of papers looking at ARBs (and especially telmisartan) in depression (such as in rodent models) they make various assumptions. But no one knows :man_shrugging:. We know have n=4 people here who noticed this effect, quite something…

5 Likes
#45

I do not take Lithium, as a supplement.

I believe Telma likely plays a part in the inflammatory process through the PPAR-y pathway which modulates inflammation.

I notice a similar effect when I take any NSAID pain relievers, however not Tylenol.

I noticed no effect on my mood with Olmesartan either.

4 Likes
#46

Based solely on my experience @zebit0, you might want to wait six weeks or so and take quite a few readings around that period (AM, PM, evening) to see how it is stabilizing. If you have not already done so, you might want to have GPT-4o respond to a complex prompt on the topic, engaging as one researcher to another. I find it almost always outperforms Claude (which I like better for other purposes) on medical research. When you have concluded your conversation with follow ups, ask it for all of the citations.

As for the 40/80 question solely as it applies to BP, I have tried a couple of runs of 80 mg. and didn’t see much difference. (However, none of them were long enough for a full shakeout.) I can’t see any near term way to assess the potential cardiac benefit, if any or me, of the higher dose.

1 Like
#47

80 mg daily is the only FDA-approved dose for “cardiovascular event risk reduction”: Optimal Blood Pressure we Should Target? Systolic Under 110 or 100? - #351 by Davin8r

2 Likes
#48

After reading a Life Extension article, I persuaded my doctor to prescribe telmisartan for blood pressure control. I took it for months without apparent issues until a dermatologist linked it to itchiness and small red spots on my extremities. The symptoms resolved months after stopping telmisartan, though this could be coincidental or a rare reaction, as I found no similar reports online. Seeking an alternative, I discovered rilmenidine, which has shown lifespan-extending effects and mimics calorie restriction in animal studies. It’s well-tolerated and approved in many countries but not yet available in the US.

2 Likes
#49

Can it be an allergy to telmisartan?

1 Like
#50

Did you have bloodwork done? I’m recently on Telmisartan and was told it can cause kidney duress. One of the signs of kidney duress is dry, itchy skin that may develop due to mineral imbalances and the buildup of waste products in the blood.
Funny thing is my doctor prescribed a years worth of Telmisartan and said if its all working for you see you in a year but my pharmacist would not refill the original 30 day prescription without me going for bloodwork checking for kidney duress first.

4 Likes
#51

What is kidney duress? Renal failure? Telmisartan like other ARBs is prescribed in CKD so I find this a bit weird.

3 Likes
#52

Lol, now be honest, adssx, do you feel your kidneys are under duress? But seriously, pubmed doesn’t return any results for me “telmisartan kidney duress”, though I did find this, noting that telmisartan has a highly individualized effect in patients:

1 Like
#53

Sorry, I’m just repeating what I was told. I did just do the bloodwork when it comes back I will specifically ask my doc what they were checking for. If your saying Telmisartan can have no negative effects on the kidneys then its possible that my pharmacist was simply overzealous although I’m not sure why my doc then ordered the bloodwork.

#54

If it took months to go away after stopping Telmisartan, I don’t think it’s from Telmisartan

#55

Just started taking telmisartan 4 days ago
For slighty elevated BP , also interested in its other benefits
I already notice changes to my stress response
And a general relaxed feeling
First , second day had a slight headache but seemed to disappear with a cardio session

6 Likes
#56

I no longer have (notice?) any nocturnal swelling. It may have been something unrelated to Telmisartan or my body has gotten used to the drug.

Unfortunately when I monitor my BP at night roughly 22 hours after dosing,( I take it after dinner) it seems it no longer has an effect on my BP.

Is this normal?

1 Like
#57

Low dose telmi, but combined wth rosuvastatin - Chinese paper[!!]:

4 Likes
#58

Since I take both a statin and Telmisartan, I’ll hope that the paper’s true. But it’s not going to change what I do either way.

1 Like
#59

I suppose since high blood pressure and high ApoB are both causing dementia, eliminating both pathways will produce synergistic results.

3 Likes
#60

It might have some synergy with the statin I currently take as well simvastatin

2 Likes
#61

It’s quite interesting. But as we’ve all learned from long experience, you can’t just assume the same result from a drug just because it belongs to the same class. And that is why you have to test the specific drug: simvastatin, rosuvastatin, etc. to make sure the effect is present, as well as the protocol (timing, dosage etc.).

I myself am switching from atorvastatin 10mg/day to pitavastatin 4mg/day precisely among other reasons because it has fewer interactions with other drugs - I’m doing this because I’m trying to lessen some of the unknown complications of polypharmacy as I add telmisartan, emplogliflozin, rapamycin and supplements, but the downside might be that I miss out on some synergies as well. That’s why I’m not going to assume that telmi and pita will synergize the same way simva and telmi or rosu and telmi do. We need to see specific combos studied to reach conclusions.

5 Likes