#41

This is not Chat AI and it gives “real” references. The reason for ambiguity is that few studies compare canola oil with olive oil. And most of the studies are weak with small cohorts. Olive oil has had countless studies about its health benefits.
There are a much smaller number of canola oil studies in humans with none having a large cohort or RCTs.
If you have a reference to a large study and/or RCT comparing the two, I would be interested in seeing it.

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#42

Wait, what? Unless I’m misremembering (which is certainly possible), he’s in amazing aerobic shape and has a coronary calcium score of 0, last I heard him talk about it. He is aggressive in keeping ApoB ultra-low because he wants to take atherosclerosis “out of the equation” for himself and his patients for all the decades to come, when at all possible.

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#43

Most people DON’T die from a heart attack (by a large margin)

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#44

Peter Attia has a family history of early cvd, so I can understand his focus on it. But then given its prevalence we all should be!

This study is interesting - showing we should be focused on inflammation as well as apo b.

“inflammation assessed by high-sensitivity CRP was a stronger predictor for risk of future cardiovascular events and death than cholesterol assessed by LDLC”

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00215-5/fulltext

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#45

But not in primary prevention for low risk individuals. I don’t think you can extrapolate and speculate that easily.

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#46

And personal risk factors. Metabolic health, smoking and blood pressure are most important IMO.

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#47

I’m not going to wait for an impossible study to be made.
Positive CAC with age tells me all I need to know.

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#48

In one of the interviews he said that he had a positive CAC in his thirties. He might reversed it since, but he has/had advanced ASCVD and his approach is really optimal in such situation.

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#49

I think you are misremembering. He had a CAC of 6 at 35 after a lifetime of near professional level athleticism and being in amazing cardio shape. People in his family were mysteriously dying of heart attacks in their 40s. He has a very high personal risk which is why he’s anal retentive over his own markers as makes sense. But he takes it too far IMO for people not on the same boat as him.

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#50

Well, it depends on what goals people have in the longevity scene. Some only want to live healthy lives then die in their 80s while others want to overcome the 120 barrier while still looking and feeling like a 20yo. The former group can probably manage just by watching intake of saturated fat while the latter group definitely needs to drive apoB to the point where plaque accumulation starts reversing.

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#51

That’s delusional. Even Attia will tell you that you won’t look or feel anything close to a 20 year old in your “marginal decade”. He’s saying do all this crazy shit so that you don’t have to be in a nursing home, not so that you do 20 year old stuff.

In my case I had grandparents who were active in their 90s despite not doing anything to worry about their mortality. Apoe4 grandma lived to 99 and you’d envy her mind right up until she was 97.

I think these notions that we’ll live forever if we only get apob low enough or vo2max high enough or this metric or that sideways are sad…. Clearly people needed the notion of immortality provided by religion and when that’s taken away from us we default to this. Not gonna happen. “Escape velocity” is poppycock. We’re hard wired to decay and die and that’s a good thing for the species. Yes it would be lovely to get to 120-150 or 200 and do more with our time but I fear people start squandering the time they’ve already got by obsessing over metrics that are in no way guaranteed to make you live as long as my grandparents, let alone beyond.

Even if you eliminate ApoB your kidneys will decay much earlier than your heart. The system is pretty much guaranteed to let you die of something. So many things fall apart simultaneously. I do think Rapa is likely to delay systemic breakdown and obsolescence. And getting metabolic health to be PERFECT is likely more important than getting apob from really good to nonexistent. And vigorous exercise will do more of course. I wonder how many of the apob fetifishts in this forum do any strength training worth speaking of.

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#52

You won’t live forever if you keep apoB low enough but if you don’t apoB will eventually get you. It’s like a ticking time bomb within your body that’s only waiting to kill you.

We’re hard wired to decay and die and that’s a good thing for the species.

I don’t care about what’s good for the species because technology is way more efficient and effective than evolution.

Even if you eliminate ApoB your kidneys will decay much earlier than your heart.

Good thing we are coming up with treatments to address every aspect of aging and not just one.

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#53

You should look up what a coronary calcium score of 6 means. Spoiler alert – it’s not high risk, not even close (“minimal risk”). And I believe he said in the same interview it was zero when he checked it again. Just because he had family members die early of heart disease doesn’t mean he’s doomed to it. They probably didn’t take care of themselves like he does.

No cardiologist would look at someone who is lean, nonsmoker, low blood pressure, professional athlete-level aerobic fitness, coronary calcium score of zero (or 6!) and label them high risk. He’s the epitome of low risk.

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#54

Striving for optimal metabolic health and the lowest possible ApoB are complementary to one another and are both important. You might want to check out the thread on SGLT2 inhibitors, which appear to slow aging (ITP trials) and also help preserve kidney function during the aging process.

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#55

You might want to check out what he himself has said on the subject instead of dispensing your wisdom. It was in an interview easily found on YouTube and linked here.

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#56

I listened to that interview. Seriously, look up calcium score of 6. Minimal risk. He’s being extra proactive because he wants to eliminate risk of heart disease by maintaining low ApoB, high metabolic health, and low/zero coronary calcium.

#57

Your healthy ldl is most likely connected with the fact that you are young. The picture usually changes with age for most ppl. My ldl and all the rest was ideal when I was your age. It’s not ideal anymore unfortunately. The trick is to figure out how to stay young when you are still young instead of trying to reverse it when it’s already late. Stay young forever! But imo it cannot be achieved without some interventions early in life.

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#58

When I say I’m not trying I mean I’m not taking statins but I do watch what I’m eating like a hawk and take a lot of supplements with ldl / apob in mind. Three years ago when I was eating like shit and was incredibly stressed at work all my biomarkers went to hell for a while so I don’t take it for granted even at a young age. All of this matters but I know for a fact even the guy obsessing over getting his apob in the 20-30 range will die same as me — and my bet will be he’ll be paying the ferryman before me.

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#59

Nah, as far as they are concerned, that is advanced heart disease. Any positive score that is.

#60

Who do you mean by “they”?